Corantes vitais em cromovitrectomia

Dib, Eduardo; Rodrigues, Eduardo B.; Maia, Maurício; Meyer, Carsten H.; Penha, Fernando M.; Furlani, Bruno; Costa, Eduardo de Freitas; Farah, Michel Eid

doi:10.1590/s0004-27492009000600022

Cited by 9 publications

(4 citation statements)

References 65 publications

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“…BBG has become a good option for ICG and infracyanine green in chromovitrectomy, because of its remarkable affinity for the ILM, although limited toxicity data in its application still warrant further investigations for confirmation of these observations [2,3,4,5]. However, many unanswered questions remain regarding the ability of BBG to stain the preretinal tissues ERM and ILM, the appropriate incubation time, or even what is the best solvent for the dyes during surgery in chromovitrectomy [4,6,11]. …”

Section: Discussionmentioning

confidence: 99%

“…In humans, BBG caused adequate ILM staining in an iso-osmolar solution of 0.25 mg/ml (0.025%) with good clinical results and no signs of toxicity in multifocal electroretinography in most studies [6,11,19,20]. However, we recently demonstrated that subretinal migration of the dye may cause atrophic changes of the retinal pigment epithelium, and therefore, we strongly suggest avoidance of BBG exposure of the RPE during chromovitrectomy [21].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, its complete removal is essential during vitreous surgery to relieve tangential traction on the fovea in various conditions, including macular holes. The intravitreous injection of vital dyes such as indocyanine green (ICG) and brilliant blue (BBG) has been reported to allow better visualization of the ILM and to contribute to safer peeling by providing a clear contrast between the membrane and the remaining retina [2,3,4,5,6]. BBG is a triarylmethane chemical with great binding affinity, approved for clinical use in Europe and the USA under the name of Brilliant Peel (Fluoron/Geuder, Ulm, Germany) [7,8,9,10].…”

Section: Introductionmentioning

confidence: 99%

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Staining Properties of Brilliant Blue Depending on Different Incubation Times and Solvents in Humans

Rodrigues¹,

Maia²,

Penha³

et al. 2013

Ophthalmologica

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Purpose: Intravitreous injection of vital dyes, e.g. brilliant blue (BBG), promotes better visualization of the internal limiting membrane (ILM). This paper investigates the staining properties of BBG depending on different incubation times and 2 types of solvents - 5% glucose (GL) or saline solution - in a prospective study in patients. Methods: This paper investigates various aspects of BBG in various methods. An interventional prospective study was conducted in patients to examine the binding properties of the blue dye diluted in either saline or 5% GL to epiretinal membranes (ERMs) and ILMs. Forty-nine consecutive patients older than 18 years scheduled for macular ERM, vitreomacular traction and macular hole surgeries were prospectively recruited. The primary outcomes of this study were the degree of ILM and ERM staining. The secondary outcomes of the study were the need of reinjection of BBG or any other dye, the ability of BBG to stain the vitreous, and frequency of complications. The staining of the ILM and ERM were graded as no staining, little, moderate or strong staining. Results: There was no correlation between age (p = 0.32) or gender (p = 0.33) in the staining affinity of BBG to either the ILM or ERM. BBG may be an appropriate staining agent for the ILM in the majority (82%) of surgeries; however, in approximately half of the cases (45%) surgeons considered BBG not enough for ERM coloring and visualization. There is a tendency of BBG to stain the ILM better when saline solution is used compared to GL 5%; however, this was not statistically significant (p = 0.64). There was no difference in the staining efficacy of BBG to the ERMs by either solution (p = 0.70), despite the low staining affinity. Conclusion: BBG became the state-of-the-art dye for ILM identification. Differences in staining properties may imply that BBG should not be considered as first-line stain for ERM surgery. BBG is effective in ILM staining in over 80% of macular hole surgeries.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Staining Properties of Brilliant Blue Depending on Different Incubation Times and Solvents in Humans

Rodrigues¹,

Maia²,

Penha³

et al. 2013

Ophthalmologica

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“…Further refinements were urgently anticipated. Various new dyes, including patent blue [52,53], bromophenol blue [54], infracyanine green [54], triamcinolone [53], fluorescein [53], aniline blue [55] and methyl blue [55], are in preclinical evaluation but cannot be recommended for routine use at this time. Another way of improving intraoperative staining might consist in upgrading existing substances with the intention of improving their efficacy.…”

Section: Ilm Materials Properties In Chromovitrectomymentioning

confidence: 99%

Material Properties of the Internal Limiting Membrane and Their Significance in Chromovitrectomy

Henrich

Monnier²,

Loparić

et al. 2013

Ophthalmologica

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Intraoperative visualization of the internal limiting membrane (ILM), the choice of a point of vantage for lifting an initial flap, the precision with which the ILM is grasped, adhesion between the forceps and the ILM, thickness, stiffness and elasticity of the ILM as well as monitoring of the completeness of ILM removal are all important factors for safety and efficacy of a chromovitrectomy intervention. The understanding of the underlying physical features of the ILM, such as contrast behavior and bioanatomical and biomechanical properties represent, thus, useful prerequisites for successful macular surgery. New analytical tools, such as atomic force microscopy and chromaticity analysis, allow new insights into ILM material characteristics, permitting a systematic approach to refinement of surgical technique.

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Development of an ion-pair to improve the colon permeability of a low permeability drug: Atenolol

Lozoya-Agullo

González‐Álvarez

et al. 2016

European Journal of Pharmaceutical Sciences

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Corantes vitais em cromovitrectomia

Cited by 9 publications

References 65 publications

Staining Properties of Brilliant Blue Depending on Different Incubation Times and Solvents in Humans

Staining Properties of Brilliant Blue Depending on Different Incubation Times and Solvents in Humans

Material Properties of the Internal Limiting Membrane and Their Significance in Chromovitrectomy

Development of an ion-pair to improve the colon permeability of a low permeability drug: Atenolol

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