Efeitos da injeção intraorbitária de carboximetilcelulose 6,0% em coelhos: análise histológica e da mecânica ocular

Simão, Maria Lúcia Habib; Chahud, Fernando; Bicas, Harley E. A.

doi:10.1590/s0004-27492009000600011

Cited by 2 publications

(1 citation statement)

References 3 publications

(3 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Through the periocular injection of viscous substances, studies have attempted to increase the passive, restraining forces to the ocular rotations (by means of increasing the friction) (13)(14)(15) . Although an increase in the periocular viscosity may reduce the angular velocity of the eye to the same applied force, it may not produce the required adjustment for a specific (desired) eye position, the establishment of a fixed direction around which the oculomotor balance must occur (e.g., the so-called primary position of gaze).…”

Section: Other Possibilitiesmentioning

confidence: 99%

A major problem in strabismus and its possible solution

Bicas¹

2014

Arquivos Brasileiros De Oftalmologia

View full text Add to dashboard Cite

Purpose: One of the challenges in strabismus is to guarantee stability of the surgical corrections. Re-surgeries are often required even after careful diagnosis, planning, and execution. Several factors contribute to this undesired outcome and the existing management strategies are ineffective. The present alternative is to compensate for their consequences. Ocular rotations are evoked by muscular contractions and relaxations (active forces). During eye movement, periocular tissues are stretched, storing part of the kinetic energy, which may be posteriorly recovered (passive forces), whereas the remaining part of the energy is lost via friction and inelastic deformations (dissipative forces). A method for measuring the forces that cause post-surgery eye drift has not been reported. However, this may be indirectly determined as a function of the respective mechanical variables. The estimated ratio between the kinetic energies of a post-surgery eye drift and a normal pursuit eye movement is ~10 -15 . Theoretically, it can be expected that the addition of continuously acting forces of such magnitudes to the oculomotor system might prevent the undesired post-surgery eye movement. Methods: Several methods for increasing the restraining, dissipative forces to ocular rotations may be conceived. One method is to increase the friction to ocular movements, as for instance, by periocular injection of viscous substances. Another possibility is to use the forces of a magnetic field, which may stabilize the eye in a desired position without avoiding the rotations caused by greater muscular forces acting on it. It has been demonstrated that these forces neutralize the nystagmic movements, whose intensities of mechanical variables are much higher than those of a post-surgery eye drift. Some models of application of this technique are then discussed. Small magnets fixed to the orbit and metallic ferromagnetic elements fixed to the sclera to cover a suitable extension appears to be the best method for providing starting and sliding friction to the oculomotor system. Results: Weak magnetic fields do not cause ocular ill effects. Additionally, the ma g netic field may be confined to the elements of the circuit and may not leak. However, the magnetic materials may interfere with magnetic resonance image (MRI) examinations. requires a detailed clinical examination and the capability to correctly interpret the collected data. Examples of diagnostic errors include unobserved muscular dysfunction and an association between the vertical and horizontal deviations, or the "V" pattern. A second factor is the surgical planning, which require a deep knowledge of the theme and excellent strategic experience necessary to relate the diagnostic findings to the expected surgical outcome. Poor selection of the extraocular muscles to be operated on or procedures to be performed on each muscle leads to undesired outcomes. The third factor is the A major problem in strabismus and its possible solution Um grande problema no estrabismo e suas po...

show abstract

Section: Other Possibilitiesmentioning

confidence: 99%

A major problem in strabismus and its possible solution

Bicas¹

2014

Arquivos Brasileiros De Oftalmologia

View full text Add to dashboard Cite

show abstract

Aromatase-Inhibitor-Induced Musculoskeletal Inflammation Is Observed Independent of Oophorectomy in a Novel Mouse Model

et al. 2022

View full text Add to dashboard Cite

Aromatase Inhibitors (AIs) block estrogen production and improve survival in patients with hormone-receptor-positive breast cancer. However, half of patients develop aromatase-inhibitor-induced arthralgia (AIIA), which is characterized by inflammation of the joints and the surrounding musculoskeletal tissue. To create a platform for future interventional strategies, our objective was to characterize a novel animal model of AIIA. Female BALB/C-Tg(NFκB-RE-luc)-Xen mice, which have a firefly luciferase NFκB reporter gene, were oophorectomized and treated with an AI (letrozole). Bioluminescent imaging showed significantly enhanced NFκB activation with AI treatment in the hind limbs. Moreover, an analysis of the knee joints and legs via MRI showed enhanced signal detection in the joint space and the surrounding tissue. Surprisingly, the responses observed with AI treatment were independent of oophorectomy, indicating that inflammation is not mediated by physiological estrogen levels. Histopathological and pro-inflammatory cytokine analyses further demonstrated the same trend, as tenosynovitis and musculoskeletal infiltrates were detected in all mice receiving AI, and serum cytokines were significantly upregulated. Human PBMCs treated with letrozole/estrogen combinations did not demonstrate an AI-specific gene expression pattern, suggesting AIIA-mediated pathogenesis through other cell types. Collectively, these data identify an AI-induced stimulation of disease pathology and suggest that AIIA pathogenesis may not be mediated by estrogen deficiency, as previously hypothesized.

show abstract

Efeitos da injeção intraorbitária de carboximetilcelulose 6,0% em coelhos: análise histológica e da mecânica ocular

Cited by 2 publications

References 3 publications

A major problem in strabismus and its possible solution

A major problem in strabismus and its possible solution

Aromatase-Inhibitor-Induced Musculoskeletal Inflammation Is Observed Independent of Oophorectomy in a Novel Mouse Model

Contact Info

Product

Resources

About