Multiple brown tumors of the orbital walls: case report

Monteiro, Mário Luiz Ribeiro

doi:10.1590/s0004-27492009000100025

Cited by 15 publications

(13 citation statements)

References 5 publications

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“…22 Only few cases have been reported in the fronto-orbital region. [9][10][11][12][13][14][15][16][17] When the orbit is affected, the presenting symptoms include a palpable mass, pain, proptosis, diplopia, impaired extrinsic ocular motility or decreased visual acuity.…”

Section: Discussionmentioning

confidence: 99%

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Single-Step Primary Reconstruction After Complex Fronto-Orbital Brown Tumor Resection Using Computed-Designed Peek Implant

Laza¹,

González²,

González-García³

et al. 2016

Surg Res Open J

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The authors describe a patient with secondary hyperparathyroidism (HPT) who had development of a brown tumors (BTs) of the superior orbit and frontal calvarium with subsequent visual impairment. One-step surgery involving wide en-bloc resection of the entire tumor and immediate fronto-orbital reconstruction with a custom-made polyetheretherketone (PEEK) implant was planned. Using a PEEK implant a one-step reconstruction of the fronto-orbital region was achieved obtaining symmetry and good functional results, reducing operative time and avoiding donor site morbidity.

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Section: Discussionmentioning

confidence: 99%

“…While the mandible is the most frequently involved bone in the head and neck region, [2][3][4][5][6][7][8] fronto-orbital involvement is extremely rare, with only a few cases in the literature. [9][10][11][12][13][14][15][16][17] Moreover, reconstruction of this region is complex and remains a challenge for maxilofacial surgeon.…”

Section: Introductionmentioning

confidence: 99%

Single-Step Primary Reconstruction After Complex Fronto-Orbital Brown Tumor Resection Using Computed-Designed Peek Implant

Laza¹,

González²,

González-García³

et al. 2016

Surg Res Open J

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“…Involvement of the orbito-frontal region and the skull base is considered rare (1,12,17,25,27). In the skull base, they usually involve one or more of the paranasal sinuses.…”

Section: Casementioning

confidence: 99%

“…Headache, swelling, and ophthalmological symptoms such as diplopia, ptosis, decreased visual acuity, decreased extraocular movement, proptosis and pain are the most common symptoms associated with skull base brown tumors (1,12,17,23,25,27).…”

mentioning

confidence: 99%

Brown tumors of the anterior skull base as the initial manifestation of true normocalcemic primary hyperparathyroidism: report of three cases and review of the literature

Khalatbari¹,

Hamidi²,

Moharamzad³

et al. 2011

Turkish Neurosurgery

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Brown tumor is a bone lesion secondary to hyperparathyroidism of various etiologies. Skeletal involvement in primary hyperparathyroidism secondary to parathyroid adenoma is very uncommon and brown tumor has become extremely a rare clinical entity. Hyperparathyroidism is usually associated with high levels of serum calcium. Brown tumor as the only and initial symptom of normocalcemic primary hyperparathyroidism is extremely rare. Moreover, involvement of the skull base and the orbit is exceedingly rare. The authors would report three cases of brown tumor of the anterior skull base that were associated with true normocalcemic primary hyperparathyroidism. Clinical manifestations, neuroimaging findings, pathological findings, diagnosis and treatment of the patients are discussed and the relevant literature is reviewed. KeywoRds: Brown tumor, Skull base, Normocalcemia, Primary hyperparathyroidism ÖZKahverengi tümör çeşitli etiyolojiler nedenli hiperparatiroidiye sekonder bir kemik lezyonudur. Paratiroid adenomuna sekonder primer hiperparatiroidide iskelet tutulumu çok nadirdir ve kahverengi tümör çok nadir bir klinik olay haline gelmiştir. Hiperparatiroidi genellikle yüksek serum kalsiyum düzeyleriyle ilişkilidir. Normokalsemik primer hiperparatiroidinin tek ve başlangıç belirtisi olarak kahverengi tümör çok nadirdir. Ayrıca kafatası tabanı ve orbitanın tutulması son derece nadirdir. Yazarlar gerçek normokalsemik primer paratiroidi ile ilişkili anterior kafatası tabanının üç kahverengi tümör vakasını sunmaktadır. Klinik bulgular, nörogörüntüleme bulguları, patolojik bulgular ve bu hastaların tanı ve tedavisi sunulmakta ve ilgili literatür gözden geçirilmektedir.

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“…Unilateral nasal obstruction, epistaxis, facial pain and local infection are the most common reported initial symptoms (13). Patients with brown tumors in the orbit may have a mass, proptosis, pain, diplopia, decreased extraocular motility or decreased visual acuity (14). Given the rarity of these tumors, lack of symptom specificity and the wide range of differential diagnoses, advanced imaging studies and precise anatomopathological analysis play a crucial role in the proper management of each case (13).…”

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confidence: 99%

Regression of orbital brown tumor after surgical removal of parathyroid adenoma

Oliveira

Makimoto

Scalissi

et al. 2015

Arch. Endocrinol. Metab.

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SUMMARYBrown tumors are rare skeletal manifestations that occur in less than 2% of primary hyperparathyroidism (PHPT) cases. Even rarer is the occurrence of brown tumor of the orbit, and few cases have been reported around the world. The rare instance of this benign tumor has prompted us to report the case and treatment of an orbital brown tumor in a patient with PHPT caused by parathyroid adenoma. We present the case of a patient undergoing follow-up at a referral center. The 60-year-old female patient, presented herself with progressive swelling in the nasal region, epistaxis and proptosis, she had noticed seven months prior to our examination. Multiple imaging and laboratory findings revealed parathyroid hormone (PTH)-dependent hypercalcemia (total calcium = 14.3 mg/dL and PTH = 1,573 pg/mL), a nodular lesion in the upper pole of the left thyroid lobe and increased uptake in left upper cervical region. The patient underwent left superior parathyroidectomy in September 2011, which led to the normalization of hypercalcemia and regression of the orbital tumor, as seen on control CT scan. This case highlights the spontaneous regression of the brown tumor after surgical management of the parathyroid adenoma. Arch Endocrinol Metab. 2015;59(5):455-9

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Multiple brown tumors of the orbital walls: case report

Cited by 15 publications

References 5 publications

Single-Step Primary Reconstruction After Complex Fronto-Orbital Brown Tumor Resection Using Computed-Designed Peek Implant

Single-Step Primary Reconstruction After Complex Fronto-Orbital Brown Tumor Resection Using Computed-Designed Peek Implant

Brown tumors of the anterior skull base as the initial manifestation of true normocalcemic primary hyperparathyroidism: report of three cases and review of the literature

Regression of orbital brown tumor after surgical removal of parathyroid adenoma

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