Indocyanine green-mediated photothrombosis for choroidal neovascularization in angioid streaks

Malerbi, Fernando Korn; Huang, Sheau Jiun; Aggio, Fábio Bom; Carvalho, Eliziane Nitz de; Bonomo, Pedro Paulo; Farah, Michel Eid

doi:10.1590/s0004-27492008000300002

Cited by 3 publications

(2 citation statements)

References 25 publications

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“…However, its use was controversial due to mixed outcomes and a tendency to cause retinal tissue damage, sub-retinal hemorrhages, and vision reduction, leading to its discontinuation [ 3 , 100 , 101 , 102 , 103 , 104 , 105 , 106 ]. Similarly, ICG-guided photothrombosis for sub-foveal CNV showed some promise with stable acuity after 12 months in a limited case series, but due to the risks of foveal damage and a lack of broader evidence, it has not been widely accepted [ 3 , 107 ].…”

Section: Narrative Review Findingsmentioning

confidence: 99%

Angioid Streaks Remain a Challenge in Diagnosis, Management, and Treatment

Tsokolas,

Tossounis,

Tyradellis

et al. 2024

Vision

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Aim: Angioid streaks (ASs) are a rare retinal condition and compromise visual acuity when complicated with choroidal neovascularization (CNV). They represent crack-like dehiscences at the level of the Bruch’s membrane. This objective narrative review aims to provide an overview of pathophysiology, current treatment modalities, and future perspectives on this condition. Materials and Methods: A literature search was performed using “PubMed”, “Web of Science”, “Scopus”, “ScienceDirect”, “Google Scholar”, “medRxiv”, and “bioRxiv.” Results: ASs may be idiopathic, but they are also associated with systemic conditions, such as pseudoxanthoma elasticum, hereditary hemoglobinopathies, or Paget’s disease. Currently, the main treatment is the use of anti-vascular endothelial growth factors (anti-VEGF) to treat secondary CNV, which is the major complication observed in this condition. If CNV is detected and treated promptly, patients with ASs have a good chance of maintaining functional vision. Other treatment modalities have been tried but have shown limited benefit and, therefore, have not managed to be more widely accepted. Conclusion: In summary, although there is no definitive cure yet, the use of anti-VEGF treatment for secondary CNV has provided the opportunity to maintain functional vision in individuals with AS, provided that CNV is detected and treated early.

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Section: Narrative Review Findingsmentioning

confidence: 99%

Angioid Streaks Remain a Challenge in Diagnosis, Management, and Treatment

Tsokolas,

Tossounis,

Tyradellis

et al. 2024

Vision

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“…Currently, treatment with these agents requires multiple injections, leading to high cost and risk of systemic adverse events. 12 Indocyanine Green Mediated Photothrombosis (IMP) which uses low power diode laser augmented with Indocyanine green dye (ICG) has been successfully used in a variety of conditions [13][14][15][16][17][18][19][20][21][22][23][24][25][26] including subfoveal CNV due to ARMD. It causes selective intraluminal photothrombosis 27 and is much cheaper than PDT.…”

Section: Introductionmentioning

confidence: 99%

Indocyanine Green Mediated Photothrombosis (IMP) with Intravitreal Bevacizumab (IVB) for Treatment of Choroidal Neovascular Membrane (CNV) due to ARMD

Seth¹

2016

DJO

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Angioid Streaks

Chatziralli

Saitakis

Dimitriou

et al. 2019

Retina

104

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Purpose: To stratify the literature on angioid streaks, from pathophysiology to treatment. Methods: Review of the current literature. Results: Angioid streaks are crack-like dehiscences of Bruch membrane, which may coexist with systemic diseases, such as pseudoxanthoma elasticum, Paget disease, Ehlers–Danlos syndrome, hemoglobinopathies, or other diseases of the collagen. Various diagnostic methods, including infrared and red-free retinography, autofluorescence, optical coherence tomography, fluorescein angiography, and indocyanine green angiography, are useful to diagnose, evaluate, and monitor angioid streaks. Choroidal neovascularization consists of a major complication of angioid streaks leading to visual impairment. Therefore, observation could not be a treatment option. Photodynamic treatment or anti–vascular endothelial growth factor agents have been used for the treatment of angioid streaks, offering promising but short-term results. Currently, the available treatment may limit the disease, but not permanently inactivate it. Conclusion: This review discusses the epidemiology, pathophysiology, diagnosis, and treatment of angioid streaks, presenting the existing literature on this topic.

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Indocyanine green-mediated photothrombosis for choroidal neovascularization in angioid streaks

Cited by 3 publications

References 25 publications

Angioid Streaks Remain a Challenge in Diagnosis, Management, and Treatment

Angioid Streaks Remain a Challenge in Diagnosis, Management, and Treatment

Indocyanine Green Mediated Photothrombosis (IMP) with Intravitreal Bevacizumab (IVB) for Treatment of Choroidal Neovascular Membrane (CNV) due to ARMD

Angioid Streaks

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