Isolated low grade pilocytic astrocytoma of the optic nerve in the elderly: case report

Hoyama, Érika; Cruz, Antônio Augusto Velasco e; Colli, Benedicto Oscar; Matos, João Roberto de; Chahud, Fernando

doi:10.1590/s0004-27492008000100020

Cited by 6 publications

(4 citation statements)

References 6 publications

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“…One of their cases had NF1. Other cases have been reported in adults (3)(4), but none appear to have been as old as ours. Unlike benign optic nerve gliomas, malignant optic nerve gliomas (MONGs) are most often reported in older individuals.…”

Section: Dr Pasolcontrasting

confidence: 47%

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Rapid Progressive Unilateral Visual Loss in an Elderly Man

Pasol

Sternau

Luetmer

et al. 2010

Journal of Neuro-Ophthalmology

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Section: Dr Pasolcontrasting

confidence: 47%

“…The typical presentation of adult optic nerve PAs is progressive loss of vision and variable proptosis (2)(3)(4). The vision can range from 20/30 to no light perception.…”

Section: Dr Pasolmentioning

confidence: 99%

Rapid Progressive Unilateral Visual Loss in an Elderly Man

Pasol

Sternau

Luetmer

et al. 2010

Journal of Neuro-Ophthalmology

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“…Other cases have been reported in adults (3)(4), but none appear to have been as old as ours. These tumors can range from low-grade tumors as in this case to infiltrating tumors such an anaplastic astrocytoma (WHO grade III) and glioblastoma (WHO grade IV).…”

Section: Dr Pasolcontrasting

confidence: 47%

Photo Essay

McCulley¹

2010

Journal of Neuro-Ophthalmology

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“…2,3 A third category of optic glioma, occurring in adulthood, histopathologically benign (WHO Grade I-II) but following an aggressive course, has been rarely reported. [4][5][6][7][8] …”

Section: Introductionmentioning

confidence: 99%

Aggressive Low-Grade Optic Nerve Glioma in Adults

Bilgin¹,

Al-Obailan²,

Bonelli³

et al. 2014

Neuro-Ophthalmology

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Primary optic nerve gliomas are most commonly benign pilocytic astrocytomas (World Health Organization [WHO] Grade I) occurring in childhood and following an indolent course. Malignant optic gliomas occur in adulthood and follow an extremely aggressive course, with rapid infiltration of the chiasm, blindness, and death typically within months. A third category of optic glioma, occurring in adulthood, histopathologically benign (WHO Grade I-II) but following an aggressive course, has been rarely reported. The authors describe clinical and histopathologic features of clinically aggressive but histopathologically benign optic nerve gliomas of adulthood. Retrospective review of cases of biopsy-proven optic nerve glioma in the neuro-ophthalmology division of the Jules Stein Eye Institute from 1990 to 2011 was carried out. Cases following an aggressive course were selected for review of clinical, neuroradiologic, and histopathologic features. Three cases were selected for detailed study. Ages ranged from 31 to 45 years. All were initially diagnosed with optic nerve inflammation or benign neoplasm based on clinical and neuroradiologic features, but all suffered neuroradiologic extension and rapid deterioration of vision in the affected eye to no light perception over 3-8 weeks. Optic nerve biopsies were undertaken for the suspicion of malignancy. Features ranged from WHO Grade I (pilocytic astrocytoma, ganglioglioma) in two cases, to WHO Grade II in one case (diffuse astrocytoma, histopathologically benign, but associated with aggressive features such as high p53 [13-21%] and ). The diffuse astrocytoma case subsequently developed extensive intracranial extension suspicious for malignant transformation. These findings indicate that benign optic nerve glioma in adults may be initially misdiagnosed as inflammation, be clinically aggressive, and require excision to prevent further intracranial involvement.

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Isolated low grade pilocytic astrocytoma of the optic nerve in the elderly: case report

Cited by 6 publications

References 6 publications

Rapid Progressive Unilateral Visual Loss in an Elderly Man

Rapid Progressive Unilateral Visual Loss in an Elderly Man

Photo Essay

Aggressive Low-Grade Optic Nerve Glioma in Adults

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