Toxicidade ocular por derivados da 4-aminoquinolona

Gouveia, Enéias Bezerra; Morales, Maira Saad de Ávila; Gouveia, Gedeão Bezerra; Lourenzi, Valeria Pinheiro M.

doi:10.1590/s0004-27492007000600033

Cited by 11 publications

(24 citation statements)

References 28 publications

(35 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Systemic administration of these drugs for a prolonged period is responsible for the appearance of multifocal hyperpigmentation, which is reversible once the medication is discontinued. Oral pigmentation secondary to drug therapy can be attributed to the stimulation of melanin production by melanocytes and/ or the deposition of metabolic products of the drugs in the tissues [3,5].…”

Section: Discussionmentioning

confidence: 99%

“…Pathologic changes in the oral mucosa can be associated with several drugs [1][2][3][4][5]. These adverse reactions depend on the drug and its pharmacodynamics and pharmacokinetics, as well as any individual variability in drug metabolism [6].…”

Section: Discussionmentioning

confidence: 99%

“…Chloroquine phosphate and hydroxychloroquine sulfate have been used since the Second World War as antimalarial agents. Furthermore, because of their immunosuppressive and anti-inflammatory actions, they came into widespread use for treating systemic and discoid lupus erythematosus, rheumatoid arthritis, cutaneous porphyria, solar hives, and other dermatological conditions [3,5]. Although these drugs yield good therapeutic results, there are significant concerns regarding the ocular toxicity of these drugs, particularly chloroquine.…”

Section: Discussionmentioning

confidence: 99%

“…Although these drugs yield good therapeutic results, there are significant concerns regarding the ocular toxicity of these drugs, particularly chloroquine. Chronic use of these drugs can result in retinal degeneration [2,7,8] that can persist even after the medication has been discontinued [5,9]. The two most important irreversible ocular side effects of chloroquine are retinotoxicity and corneal deposits [8,9].…”

Section: Discussionmentioning

confidence: 99%

“…The patient in the current case had 90% loss of vision due to the deposition of chloroquine in the pigmented retinal tissues. The daily dose of the drug seems to determine the development of ocular disease, and it should be established depending on the patient's weight; in the case of chloroquine, it should not exceed 4 mg kg -1 day -1 [5].…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

Palate Hyperpigmentation Caused by Prolonged Use of the Anti-Malarial Chloroquine

Filho

Silva

Dourado

et al. 2011

Head and Neck Pathol

View full text Add to dashboard Cite

The side-effects of many drugs manifest in the oral mucosa. The anti-malarial agent chloroquine diphosphate, which is also used to treat immunological, dermatological, and rheumatological disorders, usually causes pigmentary changes in the oral mucosa. This report presents a case of palate pigmentation related to the prolonged use of chloroquine diphosphate caused by the deposition of drug metabolites in the mucosa. Healthcare professionals must be aware of these drugs and their adverse effects in order to make the correct diagnosis, decide on the optimal treatment for the condition, or refer the patient to an appropriate specialist.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Palate Hyperpigmentation Caused by Prolonged Use of the Anti-Malarial Chloroquine

Filho

Silva

Dourado

et al. 2011

Head and Neck Pathol

View full text Add to dashboard Cite

show abstract

Electrocatalytic Determination of Hydroxychloroquine Using Sodium Dodecyl Sulphate Modified Carbon Nanotube Paste Electrode

et al. 2022

View full text Add to dashboard Cite

Selective, sensitive, easy, and fast voltammetric techniques were developed for the analysis of Hydroxychloroquine (HCQ). These analysis were carried out at sodium dodecyl sulphate modified carbon nanotube paste electrode (SDSMCNTPE) using an aqueous 0.2 M phosphate buffer solution as supporting electrolyte. The field emission-scanning electron microscopy, cyclic voltammetry (CV), and electrochemical impedance spectroscopy were used for material characterization. A minute quantity of the SDS surfactant was sufficient to convey an outstanding electrocatalytic action to the electrochemical oxidation nature of HCQ. The HCQ molecule parades only electrochemical oxidation (irreversible) with the transfer of two electrons. The detection of HCQ was carried out through CV method at SDSMCNTPE and bare carbon nanotube paste electrode (BCNTPE). The corresponding analytical curve offered a decent linear nature in the considered HCQ concentration range (10–40 µM) and the detection limit was found to be 0.85 µM. The significant peak to peak split-up was observed between HCQ and interferents with a decent sensitivity and stability. The SDSMCNTPE to be an approachable electrode for the usage in the examination of HCQ independently and in the presence of paracetamol (PC) and ascorbic acid (AA). Thus, they were used to determine HCQ in pharmaceutical formulations and the results that showed good agreement with comparative methods. Furthermore, a mechanism for HCQ electro-oxidation was proposed.

show abstract

Cyclodextrin-mediated gold nanoparticles as multisensing probe for the selective detection of hydroxychloroquine drug

George

Mathew

2021

Korean J. Chem. Eng.

View full text Add to dashboard Cite

β -Cyclodextrin ( β -CD) modified gold nanoparticles (AuNP) were rapidly synthesized using microwave assisted procedure. Parameters, such as time, pH and concentrations of β -CD and gold, were optimized for the synthesis of β -CD-AuNP. The addition of enantiomers and racemic mixture of hydroxychloroquine (R-HCQ, S-HCQ and RS-HCQ) drugs and their interaction with β -CD led to a red shift in the surface plasmon resonance of β -CD-AuNP. The changes associated with the introduction of HCQ in β -CD-AuNP were studied using various characterization techniques such as UV-vis, FT-IR, XRD, dynamic light scattering, zeta potential, transmission electron microscopy, fluorescence spectroscopy and electrochemical techniques. The host-guest interaction of β -cyclodextrin with S-HCQ, R-HCQ and RS-HCQ resulted in the aggregation of gold nanoparticles. The surface plasmon resonance at 521 nm for β -CD-AuNP was shifted to 600, 620 and 670 nm on the addition of S-HCQ, R-HCQ and RS-HCQ, respectively, with a color change from pink to blue. The selectivity and sensitivity of the developed system for RS-HCQ were investigated and the limit of detection (LOD=3 s/m) was found to be 2.61, 0.15, and 0.85 nM for optical, fluorescence and electrochemical methods, respectively. The successful monitoring of RS-HCQ drug in pharmaceutical samples is possible with these techniques. Electronic Supplementary Material Supplementary material is available for this article at 10.1007/s11814-020-0719-7 and is accessible for authorized users.

show abstract

Toxicidade ocular por derivados da 4-aminoquinolona

Cited by 11 publications

References 28 publications

Palate Hyperpigmentation Caused by Prolonged Use of the Anti-Malarial Chloroquine

Palate Hyperpigmentation Caused by Prolonged Use of the Anti-Malarial Chloroquine

Electrocatalytic Determination of Hydroxychloroquine Using Sodium Dodecyl Sulphate Modified Carbon Nanotube Paste Electrode

Cyclodextrin-mediated gold nanoparticles as multisensing probe for the selective detection of hydroxychloroquine drug

Contact Info

Product

Resources

About