Aspectos patológicos da retinopatia diabética

Corrêa, Zélia M.; Eagle, Ralph C.

doi:10.1590/s0004-27492005000300028

Cited by 12 publications

(13 citation statements)

References 19 publications

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“…These cells found to be important in the disease development, since they are lost in the early stages of DR [5–7]. However, not only pericytes are affected by the disease.…”

Section: Introductionmentioning

confidence: 99%

Risk factors for diabetic retinopathy: a case–control study

et al. 2016

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BackgroundDiabetic retinopathy (DR) is the major cause of blindness among working age adults. The aim of the study was to investigate risk factors for development of DR.MethodsA case–control study was performed based on data from 240 individuals (80 cases and 160 controls) attending the Outpatient Specialty Clinic of the University of South Santa Catarina (UNISUL), between Mar/2010 and May/2014. Data collection occurred through review of medical charts for presence or absence of DR, determined by an ophthalmologist. Study protocol included demographic characteristics, metabolic control, diabetes mellitus (DM) profile and comorbidities. Statistical analysis used Chi square test for qualitative variables and multivariate logistic regression analysis to select independent variables (SPSS®18.0 software). Odds ratio (OR) was used as measure of association. The study was approved by research ethics committee of UNISUL.ResultsMean age of group case was 59.5 years with a slight female predominance. Gender, age, body mass index were not associated with outcome. Individuals with poor glycemic control were more likely to DR (OR 3.83; 95 % CI 1.57–9.37). It was observed a positive relationship between duration of DM and DR, with higher chances in 11–15 years of disease (OR 7.52, 95 % CI 3.03–18.68) and >15 years (OR 9.01, 95 % CI 3.58–22.66). Regarding comorbidities, only diabetic nephropathy showed higher chance for DR (OR 3.32; 95 % CI 1.62–6.79).ConclusionsDiabetic patients after 10 years of disease with poor glycemic control and nephropathy have a higher chance of DR.

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“…These cells found to be important in the disease development, since they are lost in the early stages of DR [5–7]. However, not only pericytes are affected by the disease.…”

Section: Introductionmentioning

confidence: 99%

Risk factors for diabetic retinopathy: a case–control study

et al. 2016

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“…A hiperglicemia é um dos fatores envolvidos na etiologia das complicações crônicas do Diabetes mellitus. Acredita-se que as mais importantes complicações do diabetes como retinopatia, nefropatia e neuropatia, sejam devidas à hiperglicemia (27). Ainda que para complicações microvasculares o controle glicêmico tenha maior significância, os fatores de risco são semelhantes aos expostos para doença macrovascular (5,8).…”

Section: Métodounclassified

Ocorrência De Complicações Crônicas E Seus Fatores De Risco Em Pacientes Diabéticos Atendidos Pelo Programa Saúde Da Família De Muriaé-Mg

Netto¹,

Oliveira

2015

Infarma

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O objetivo deste trabalho foi analisar a ocorrência de complicações associadas ao diabetes e identificar seus fatores de risco em indivíduos com diabetes mellitus assistidos pelo Programa Saúde da Família de Muriaé-MG. Foi realizado um estudo quantitativo, transversal no período de fevereiro a junho de 2009 na unidade do Programa de Saúde da Família (PSF) do bairro São Gotardo no município de Muriaé, MG. A amostra foi constituída por 50 pacientes. As informações de cada participante foram obtidas por meio de um questionário estruturado. As informações sobre a ocorrência de complicações crônicas do diabetes foram obtidas por meio da análise dos prontuários dos pacientes. Foi observado que 23 (46,0%) pacientes não apresentavam complicação da doença, enquanto 27 (54,0%) apresentavam pelo menos uma complicação, sendo as mais frequentes retinopatia, presente em 18 (66,67%) pacientes, doenças cardiovasculares (14, 51,85%) e neuropatia diabética (11, 40,74%). Os fatores de risco mais prevalentes foram sedentarismo (39, 78,0%), obesidade central (7, 74,0%) e HAS (35, 70,0%). Ainda são necessários grandes esforços na atenção primária ao paciente diabético com relação ao tratamento adequado da doença e à adesão de hábitos de vida saudáveis, pois a presença de complicações associadas ao estado de saúde geral dos pacientes diabéticos diminui significativamente a qualidade de vida desta população.

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“…In humans, the onset of the disease is characterized by microaneurysms formation from small capillary beds sacculations that rupture and progress to hemorrhagic spots with or without exudation (Narfstrom & Petersen-Jones 2013). Diabetic retinopathy in humans can be classified according to its evolution, according to Early Treatment Diabetic Retinopathy Study (ETDRS) in mild non-proliferative DR, moderate to severe non-proliferative DR or preproliferative DR and proliferative DR (Corrêa & Eagle Junior 2005).…”

Section: Introductionmentioning

confidence: 99%

Retina assessment by optical coherence tomography of diabetic dogs

et al. 2018

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Diabetes mellitus is one of the most common endocrine disorders characterized by relative or absolute lack of insulin; this can lead to several ocular manifestations, among them diabetic retinopathy and cataracts. Diabetic retinopathy (DR) is a microangiopathy that involves retinal precapillary arterioles, postcapillary venules, and large vessels, causing them to be functionally and anatomically incompetent. Hyperglycemia seems to be the most probable cause of damage to the retina due to interference in cellular metabolism and transduction processes. The aim of this study was to evaluate retinal thickness in eight diabetic dogs, four females and four males of different breeds and ages ranging from 6 to 15 years, by optical coherence tomography (OCT) and to compare them with non-diabetic dogs. Assessment provided by OCT in diabetic dogs showed retinal layers thinning and loss of stratification when compared to non-diabetic dogs (198μm versus 219μm respectively), with statistical significance (p=0.008). OCT images may suggest that diabetes mellitus causes retinal neuropathy in dogs, as also seen in diabetic humans.

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Aspectos patológicos da retinopatia diabética

Cited by 12 publications

References 19 publications

Risk factors for diabetic retinopathy: a case–control study

Risk factors for diabetic retinopathy: a case–control study

Ocorrência De Complicações Crônicas E Seus Fatores De Risco Em Pacientes Diabéticos Atendidos Pelo Programa Saúde Da Família De Muriaé-Mg

Retina assessment by optical coherence tomography of diabetic dogs

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