Uveítes anteriores associadas a doenças sistêmicas

Dimantas, Maria Angélica P; Lowder, Careen Y.; Muccioli, Cristina

doi:10.1590/s0004-27492003000200023

Cited by 4 publications

(2 citation statements)

References 13 publications

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“…In addition, laboratory evaluation displayed normal values of serum lysozyme and angiotensin-converting enzyme. However, patients with active ocular sarcoidosis may be in systemic remission already, justifying a possible decrease in angiotensin-converting enzyme values [8]. Moreover, a suspected chest radiography image motivated additional workup and a definite diagnosis of sarcoidosis through mediastinal lymph node biopsy.…”

Section: Discussionmentioning

confidence: 99%

Low dose corticosteroid in association with methotrexate for therapy of ocular sarcoidosis: report of a case

et al. 2015

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Sarcoidosis is a multisystem granulomatous disease of unknown etiology. Ocular involvement can be the initial manifestation, occurring by itself, or it can be associated with other systemic signs of sarcoidosis. A 31 years-old caucasian female presented a 10-day history of decreased vision and pain in OS. Biomicroscopy revealed fine keratic precipitates, a mild reaction in the anterior chamber and in the vitreous cavity in both eyes and a small posterior synechiae in OS. Intraocular pressure was 12 mmHg in the OD and 9 mmHg in OS. Fundoscopy disclosed mild swollen and hyperemic optic discs and some subretinal yellowish nodules of 1/3 to 1 disc diameter, partially delimited, located in the posterior pole and midperiphery in both eyes. The Chest X-ray disclosed the suspicion of hilar lymphadenopathy, especially on the left-side. The positron emission tomography (PET-scan) showed increased 18 F-fluorodeoxyglucose uptake in the paratracheal and bilateral hilar lymph nodes, indicating high local cellular metabolism. A mediastinal lymph node biopsy was performed afterwards, which depicted non-caseating granulomas with multinucleated giant cells and absence of acid-alcohol resistant bacilli. The patient was initially treated with oral prednisone 60 mg/day with slow tapering over the next months. A decreased papillitis and an increased size of the choroidal granulomas was observed after a 6-month therapy (Figs. 1B and 2B). Then, a combination of methotrexate 20 mg/week and prednisone 10 mg/day was given over the following months, which led to a gradual reduction in size and thickness of the choroidal granulomas. A weak response to steroid monotherapy was initially observed in this patient. The introduction of a non-steroid immunosuppressant drug (methotrexate) was associated with significant anatomic improvement in the following months. This report raises the suggestion that an early introduction of a nonsteroidal immunosuppressive drug to systemic steroids may be beneficial for a rapid remission of the uveitis.

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Section: Discussionmentioning

confidence: 99%

Low dose corticosteroid in association with methotrexate for therapy of ocular sarcoidosis: report of a case

et al. 2015

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“…3 This classification helped to standardize the nomenclature and understand the factors related to the natural history of the various types of uveitis involved, among other factors, anatomical, clinical and evolutionary aspects. 4 Due to the wide variety of causes of uveitis, it is common the influence of factors such as age, gender, race, geographic location, social factors, immunological factors, among others. Given the abundance of diseases that can originate them, it is important to undertake studies of prevalence.…”

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confidence: 99%

Study of the prevalence of uveitis in a tertiary ophthalmology hospital in Teresina, Piauí, Brazil

Teixeira

Abrahao

Dalia

et al. 2016

Revista Brasileira De Oftalmologia

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Teresina, Piauí, Brasil Study of the prevalence of uveitis in a tertiary ophthalmology hospital in Teresina, Piauí, Brazil RESUMO Objetivo: analisar a prevalência das uveítes em pacientes atendidos em um serviço oftalmológico terciário em Teresina, Piauí. Métodos: estudo retrospectivo baseado em prontuários de pacientes atendidos nesse serviço. Foram descritos: gênero, faixa etária, procedência, doença de base, diagnóstico anatômico, aspecto clínico e tempo de evolução. Resultados: foram incluídos 403 prontuários constatando-se que a cada 1000 pacientes atendidos neste serviço, 3,2 tinham uveíte. A idade média dos pacientes foi de 42 anos, tanto o gênero feminino (50,6%) quanto o gênero masculino (49,4%) foram acometidos similarmente, com 61,5% dos pacientes provenientes da capital. A doença de base mais frequente foi a toxoplasmose, seguida das uveítes idiopáticas apenas com manifestações oculares. Quanto à classificação anatômica, 49,6% foram posteriores e 3,5% foram intermediárias. Em relação ao aspecto clínico, 64% foram granulomatosas, 24,8% não-granulomatosas e 11,2% não foram classificáveis. Segundo a evolução clínica, 41,4% foram agudas, seguidas de 30,8% crônicas, 14,4% recorrentes e em 13,4% os pacientes não foi feito o acompanhamento. Conclusão: pudemos constatar que para cada 1000 pacientes atendidos neste serviço 3,2 tinham uveíte, apresentando-se a toxoplasmose como importante fonte de uveíte neste serviço.Descritores: Toxoplasmose ocular; Uveíte idiopática; Uveíte/classificação Due to the wide variety of causes of uveitis, it is common the influence of factors such as age, gender, race, geographic location, social factors, immunological factors, among others. Given the abundance of diseases that can originate them, it is important to undertake studies of prevalence. They contribute to preventive planning, diagnostic and therapeutic of the most frequent clinical entities.In the absence of a similar study in Piauí, and considering that Teresina has been for many years standing out in the middle northern Brazil as a reference point in medicine and health, the present study aims to analyze the prevalence of uveitis in patients in a tertiary ophthalmic service. METHODSA retrospective cross-sectional descriptive epidemiological study was conducted based on the query to electronic records of patients seen at Hospital de Olhos Francisco Vilar (Teresina, Piauí) during the period from January 1 A search strategy about the electronic medical records from the hospital was followed, searching for keywords including uveitis, and synonyms sucha as iritis and iridocyclitis, besides the search for underlying diseases (toxoplasmosis, toxocariasis, tuberculosis, Reiter's syndrome, sarcoidosis, syphilis, rheumatoid arthritis, juvenile rheumatoid/idiopathic arthritis, acquired immunodeficiency syndrome -AIDS, Behcet's disease, ankylosing spondylitis, systemic lupus erythematosus, cytomegalovirus, herpes simplex, Vogh-Koyanagi-Harada syndrome, Fuchs' heterochromic iridocyclitis) that could lead to the same...

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Ocular complications in adults with psoriasis: a cross-sectional study in a referral center in Brazil

Oliveira,

Faneli,

Amaral

et al. 2024

Int Ophthalmol

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Purpose There is limited literature on the ocular manifestations in patients with psoriasis. Therefore, this study aimed to identify the prevalence of and factors associated with ocular manifestations in adults with psoriasis. Methods This cross-sectional study included Brazilian adults with psoriasis. The dermatological evaluation included diagnosis, clinical form, Psoriasis Area and Severity Index (PASI) measurement, and location of the lesions. Patients underwent a full ophthalmological examination, including the Schirmer I test, Rose Bengala staining, and tear breakup time tests. The results were analyzed using chi-square and Pearson’s linear correlation tests. Results Of the 130 patients assessed, 118 (90.8%) exhibited ocular abnormalities, with meibomian gland dysfunction (MGD) being the most prevalent (59.2%), followed by dry eye disease (DED) (56.2%). A significant correlation was observed between MGD and PASI (p = 0.05), and between MGD and certain treatment modalities. DED was significantly associated with PASI (p < 0.05). Concurrent use of acitretin was identified as an independent predictor of MGD (odds ratio [OR] = 3.5, p < 0.05), whereas PASI was a protective factor against DED (OR = 0.39, p < 0.01). Conclusion Given the high prevalence of eye disease among individuals with psoriasis, routine ophthalmological assessments are recommended to prevent possible ocular complications.

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Uveítes anteriores associadas a doenças sistêmicas

Cited by 4 publications

References 13 publications

Low dose corticosteroid in association with methotrexate for therapy of ocular sarcoidosis: report of a case

Low dose corticosteroid in association with methotrexate for therapy of ocular sarcoidosis: report of a case

Study of the prevalence of uveitis in a tertiary ophthalmology hospital in Teresina, Piauí, Brazil

Ocular complications in adults with psoriasis: a cross-sectional study in a referral center in Brazil

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