Neuroproteção: situação atual no glaucoma

Marigo, Flavio A; Cronemberger, Sebastião; Calixto, Nassim

doi:10.1590/s0004-27492001000200016

Cited by 1 publication

(1 citation statement)

References 41 publications

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“…Nevertheless, resistance to the development of glaucoma demonstrated by some individuals with ocular hypertension and the apparent occurrence of glaucoma in rare individuals with normal or slightly above the normal IOP (normal-tension glaucoma) shows that IOP is not the only significant factor for the disease. Tolerance to a certain IOP contributes to individual variation in the disease, and other factors such as increased ocular peripheral vascular resistance, reduction of blood flow to the optic nerve, the action of excitotoxins, and depletion of neurotrophins in the retinal ganglion cells can interfere, increasing predisposition to glaucoma or triggering it (Marigo et al, 2001). Several reports implicate genetic factors in the etiology of glaucoma; the condition is usually seen in related individuals and specific ethnic groups, often associated with consanguinity in affected families (Sarfarazi et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

GSTM1 polymorphism in patients with primary open-angle glaucoma

Barbosa

Frare²,

Costa³

et al. 2012

Genet. Mol. Res.

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ABSTRACT. Primary open-angle glaucoma (POAG) is characterized by loss of retinal ganglion cells, optic nerve damage and irreversible loss of visual field. Glaucoma is the second leading cause of blindness worldwide. It was estimated that in 2010 there were about 60.5 million glaucoma cases worldwide; among these patients, 4.5 million will become bilaterally blind. Glutathione S-transferases (GST) are a group of drug-metabolizing enzymes of phase-II that act in the detoxification of xenobiotics and inactivate end-products formed as secondary metabolites during oxidative stress. Through PCR amplification, we analyzed the GSTM1 gene in DNA samples from 25 patients with POAG and 25 controls; 14 of the patients presented the GSTM1 gene null polymorphism while only eight of the control group had this gene. ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 11 (3): 3256-3262 (2012) GSTM1 polymorphism in primary open-angle glaucoma 3257Although the POAG patients had a higher frequency of GSTM1, the difference was not significant (P = 0.0874); this lack of significance could be due to the small sample size.

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Section: Introductionmentioning

confidence: 99%