Achados oculares e fundoscópicos em pacientes com lupus eritematoso sistêmico

Bigolin, Silvane; Oyamaguchi, Emerson Kenji; Claro, C; Bryk, Agostinho; Komatsu, Machiko; Belotto, Eduardo; Postella, Ezequiel

doi:10.1590/s0004-27492000000500011

Cited by 4 publications

(5 citation statements)

References 9 publications

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“…19 Another study has found 5% of changes in the pigmented epithelium of retina. 22 We found no patient with those changes. Patients with SLE and high titers of anticardiolipin antibodies have a greater risk of developing occlusive ocular vascular disease.…”

Section: Discussionmentioning

confidence: 63%

Alterações oftalmológicas decorrentes do tratamento do lúpus eritematoso sistêmico juvenil

Fraga¹,

Len²,

Finamor³

et al. 2011

Rev. Bras. Reumatol.

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Objective: To assess retrospectively the ocular changes in children and adolescents with juvenile systemic lupus erythematosus (JSLE) in a tertiary pediatric rheumatology service. Methods: This study assessed 117 JSLE patients (85.5% female, 60.7% non-Caucasian), who met at least four criteria of the 1997 SLE classifi cation of the American College of Rheumatology. Their mean age was 10.4 years, and their mean time of disease progression was 5.4 years. A protocol containing clinical and demographic data, ophthalmologic complaints and changes, age of onset, duration of medication use, and cumulative medication dose was applied. Results: Of the 117 patients, 24 (20.5%) had ocular changes. Sixteen of them had abnormal fundoscopy associated with systemic hypertension and/or use of chloroquine; four had cataract; two had glaucoma; and two had cataract and glaucoma. The mean age of ocular change onset was 14.1 years. Patients with ocular changes received statistically higher and longer doses of glucocorticoid pulse therapy as compared with patients without ocular changes [1.5 (0.4 to 1.6) versus 1 (0.2 to 1.6) mg/kg, P = 0.003; 25.7 (2-99) versus 17.8 (1-114) months, P = 0.0001, respectively]. Conclusion: A high prevalence of ocular changes relating mainly to the treatment of JSLE was observed. This demonstrates the need for regular ophthalmologic examinations even in asymptomatic patients, aiming at the early diagnosis and intervention, and at decreasing the ocular morbidity related to that disease.

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Section: Discussionmentioning

confidence: 63%

Alterações oftalmológicas decorrentes do tratamento do lúpus eritematoso sistêmico juvenil

Fraga¹,

Len²,

Finamor³

et al. 2011

Rev. Bras. Reumatol.

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“…Na literatura nacional, foi publicado estudo realizado com 41 pacientes cuja média de idade encontrada foi de 32,22 anos e duração média da doença de 6,17 anos (12) . No nosso trabalho, encontramos uma média de idade de 43,9 anos (± 10,7 anos), variando de 14 a 68 anos, com duração média da doença de 12,9 anos, demonstrando uma faixa etária média mais avançada com um maior tempo de duração da doença.…”

Section: Discussionunclassified

“…Soo et al relata apenas um paciente com glaucoma na sua série de 52 pacientes (8) . Bigolin et al reportaram 2 pacientes (4,8%) com aumento da pressão intra-ocular e escavação do disco óptico consideradas patológicas (12) . Presença de drusas coroidianas foi identificada em 8 pacientes (11,4%).…”

Section: Discussionunclassified

Alterações oculares nos pacientes portadores de lúpus eritematoso sistêmico em acompanhamento ambulatorial

Klejnberg

Moraes²

2006

Arq. Bras. Oftalmol.

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“…O envolvimento ocular é comum e inclui lesão cutânea palpebral, síndrome de Sjögren secundária, lesões vasculares retinianas e lesões neuro-oftálmicas (2)(3)(4)(5)(6)(7)(8) . As manifestações vasculares retinianas constituem a forma mais comum de envolvimento ocular, sendo encontradas em 29% dos pacientes e caracterizadas, na maioria dos casos, por manchas algodonosas com ou sem hemorragias intra-retinianas (9) .…”

Section: Introductionunclassified