Effect of mydriatic and cycloplegic drugs in glaucomatous and nonglaucomatous eyes using ultrasound biomicroscopy

Abstract

Purpose: To study the anatomical relationships of the anterior segment of the eye, using ultrasound biomicroscopy in patients with chronic simple glaucoma and nonglaucomatous eyes, after mydriatic and cycloplegic instillation.Patients and Methods: Thirty eyes with chronic simple glaucoma and 30 nonglaucomatous eyes were studied. Anterior chamber depth, irislens contact and iris-zonule distance were measured, in both groups, using ultrasound biomicroscopy, in the three following conditions: without mydriatic and cycloplegic instillation, with 1% tropicamide alone and with 1% tropicamide plus 10% phenylephrine chlorhydrate.Results: Ultrasound biomicroscopy examinations of glaucomatous and nonglaucomatous eyes, without mydriatic and cycloplegic instillation, showed no statistically significant difference in the central anterior chamber depth, iris-lens contact and iris-zonule distance. The difference between examinations without mydriatic and cycloplegic instillation, with 1% tropicamide and with 1% tropicamide plus 10% phenylephrine chlorhydrate was statistically significant regarding the variables measured in both groups.Conclusions: No anatomical difference was observed between the anterior segment of glaucomatous and nonglaucomatous eyes after mydriatic and cycloplegic instillation. The results of this clinical investigation, using ultrasound biomicroscopy were innovative, allowing a dynamic and quantitative evaluation of the anatomical relationships between intraocular structures when submitted to mydriasis and cycloplegy, which up to now were only qualitative. Efeito de drogas midriáticas e cicloplégicas em olhos glaucomatosos e não glaucomatosos usando a biomicroscopia ultra-sônicaTrabalho realizado no Departamento de Oftalmologia da Universidade Federal de São Paulo (UNIFESP), Brasil. Foi parcialmente apresentado no XIII Congresso Brasileiro de Prevenção da Cegueira e Reabilitação Visual. Os autores não tiveram interesse financeiro nos instrumentos ou nas medicações referidas neste estudo.(1)