Papel do fator de crescimento vascular endotelial na angiogênese e na retinopatia diabética

Valiatti, Fabiana Borba; Crispim, Daisy; Benfica, Camila Zanella; Valiatti, Bruna Borba; Kramer, Caroline; Canani, Luís Henrique Santos

doi:10.1590/s0004-27302011000200002

Cited by 24 publications

(6 citation statements)

References 51 publications

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“…Endothelial dysfunction has also been shown to lead to an uncoupling of the vascular endothelial growth factor (VEGF)-nitric oxide axis resulting in enhanced proinflammatory and proliferative effects of VEGF [36,37]. VEGF is increased in glomeruli and tubules in response to hyperglycemia.…”

Section: Introductionmentioning

confidence: 99%

Nitric oxide system and diabetic nephropathy

Dellaméa

Leitão

Friedman

et al. 2014

Diabetol Metab Syndr

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About 30% of patients with type 2 diabetes mellitus develop clinically overt nephropathy. Hyperglycemia is necessary, but not sufficient, to cause the renal damage that leads to kidney failure. Diabetic nephropathy (DN) is a multifactorial disorder that results from interaction between environmental and genetic factors. In the present article we will review the role of the nitric oxide synthase (NOS) in the pathogenesis of DN.Nitric oxide (NO) is a short-lived gaseous lipophilic molecule produced in almost all tissues, and it has three distinct genes that encode three NOS isoforms: neuronal (nNOS), inducible (iNOS) and endothelial (eNOS).The correct function of the endothelium depends on NO, participating in hemostasis control, vascular tone regulation, proliferation of vascular smooth muscle cells and blood pressure homeostasis, among other features. In the kidney, NO plays many different roles, including control of renal and glomerular hemodynamics. The net effect of NO in the kidney is to promote natriuresis and diuresis, along with renal adaptation to dietary salt intake.The eNOS gene has been considered a potential candidate gene for DN susceptibility. Three polymorphisms have been extensively researched: G894T missense mutation (rs1799983), a 27-bp repeat in intron 4, and the T786C single nucleotide polymorphism (SNP) in the promoter (rs2070744). However, the potential link between eNOS gene variants and the induction and progression of DN yielded contradictory results in the literature.In conclusion, NOS seems to be involve in the development and progression of DN. Despite the discrepant results of many studies, the eNOS gene is also a good candidate gene for DN.

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Section: Introductionmentioning

confidence: 99%

Nitric oxide system and diabetic nephropathy

Dellaméa

Leitão

Friedman

et al. 2014

Diabetol Metab Syndr

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“…Bevacizumab (Avastin®, Genentech) is a full-length humanized antibody that targets all subtypes of VEGF [ 49 ]. Intravitreal injection of Avastin has led to the reduction of vascular permeability, and retinal and choroidal neovascularisation, all of which are precursor lesions for developing PDR and AMD [ 50 – 53 ]. In addition, intravitreal Avastin therapy was reported to reduce iris and retinal neovascularization [ 54 ].…”

Section: Therapeutic Approaches and Their Current Delivery Systemmentioning

confidence: 99%

Current Advances in Pharmacotherapy and Technology for Diabetic Retinopathy: A Systematic Review

Jiang

Jaganathan

et al. 2018

Journal of Ophthalmology

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Diabetic retinopathy (DR) is classically defined by its vascular lesions and damage in the neurons of the retina. The cellular and clinical elements of DR have many features of chronic inflammation. Understanding the individual cell-specific inflammatory changes in the retina may lead to novel therapeutic approaches to prevent vision loss. The systematic use of available pharmacotherapy has been reported as a useful adjunct tool to laser photocoagulation, a gold standard therapy for DR. Direct injections or intravitreal anti-inflammatory and antiangiogenesis agents are widely used pharmacotherapy to effectively treat DR and diabetic macular edema (DME). However, their effectiveness is short term, and the delivery system is often associated with adverse effects, such as cataract and increased intraocular pressure. Further, systemic agents (particularly hypoglycemic, hypolipidemic, and antihypertensive agents) and plants-based drugs have also provided promising treatment in the progression of DR. Recently, advancements in pluripotent stem cells technology enable restoration of retinal functionalities after transplantation of these cells into animals with retinal degeneration. This review paper summarizes the developments in the current and potential pharmacotherapy and therapeutic technology of DR. Literature search was done on online databases, PubMed, Google Scholar, clinitrials.gov, and browsing through individual ophthalmology journals and leading pharmaceutical company websites.

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“…To evaluate the dynamics of endothelial growth we used the marker VEGF which has an important role in the development of new vessels and in the increased vascular permeability. 48 In addition, serum levels of VEGF were used as an independent predictor of SLE activity. However, there are studies showing similar alterations in SLE patients.…”

Section: Analysis Of Anti-dna Antibodiesmentioning

confidence: 99%

Effect of chronic exposure to fine particulate matter on cardiac tissue of NZBWF1 mice

Waked

Rodrigues

Silva

et al. 2023

Int J Experimental Path

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Epidemiological and toxicological studies have shown that inhalation of particulate matter (PM) is associated with development of cardiovascular diseases. Long-term exposure to PM may increase the risk of cardiovascular events and reduce life expectancy. Systemic lupus erythematosus (SLE) is a chronic in ammatory disease with autoimmune nature, characterized by the production of autoantibodies that affects several organs, including the heart. Caused by several factors, air pollution, may appear as one of the most important points on the onset and development of SLE. This study aims to investigate whether exposure to air pollution promotes increased in ammation and cardiac remodeling in animals predisposed to SLE. Female mice of NZBWF1, were used in an environmental particle concentrator. Aspects related to cardiac remodeling, in ammation and apoptosis in myocardium were analyzed. Body weight gain, cardiac trophism by heart/body weight ratio, relative area of cardiomyocytes and brotic area of cardiac tissue were evaluated during exposure period. Animals exposed to PM2.5 showed increased area of cardiomyocytes, and area of brosis, in addition, we observed an increase of IL-1 and C3 in cardiac tissue, demonstrating increased in ammation. We suggest that air pollution is capable of promoting cardiac remodeling and increased in ammation in animals predisposed to SLE.

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Papel do fator de crescimento vascular endotelial na angiogênese e na retinopatia diabética

Cited by 24 publications

References 51 publications

Nitric oxide system and diabetic nephropathy

Nitric oxide system and diabetic nephropathy

Current Advances in Pharmacotherapy and Technology for Diabetic Retinopathy: A Systematic Review

Effect of chronic exposure to fine particulate matter on cardiac tissue of NZBWF1 mice

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