Efeito dos ácidos graxos n-3 no perfil glicêmico e lipídico, no estresse oxidativo e na capacidade antioxidante total de pacientes com síndrome metabólica

Simão, Andréa Name Colado; Godeny, Paula; Lozovoy, Marcell Alysson Batisti; Dichi, Jane Bandeira; Dichi, Isaías

doi:10.1590/s0004-27302010000500006

Cited by 21 publications

(5 citation statements)

References 37 publications

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“…Similar results were found in fish oil (3 g) research, rich in polyunsaturated fatty acids, indicating a reduction of TG in the group that used fish oil when compared to the control group (without substance use). In addition to this indicator, there was an increase in total antioxidant capacity [ 47 ], a fact that was also observed in our study with GB supplementation. The reduction in TG levels observed in the C group is probably due to the introduction in the diet of a greater quantity of fruits and vegetables since all the volunteers were directed to introduce a healthy diet as described in Materials and Methods.…”

Section: Discussionsupporting

confidence: 84%

Lycium barbarumReduces Abdominal Fat and Improves Lipid Profile and Antioxidant Status in Patients with Metabolic Syndrome

Zanchet

Nardi

Bratti

et al. 2017

Oxidative Medicine and Cellular Longevity

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Natural antioxidants present in fruits have attracted considerable interest due to their presumed safety and potential nutritional value. Even though antioxidant activities of many fruits have been reported, the effects of phytochemicals of goji berry (GB) in patients with metabolic syndrome have not been investigated. In this study, we examined anthropometric and biochemical parameters in patients with metabolic syndrome after the consumption of GB. The patients were divided into two groups, control (C) and supplemented (S), and followed up for 45 days. Participants were individually instructed to carry out a healthy diet, but additionally, an inclusion of 14 g of the natural form of goji berry in the diet during 45 days for the S group was proposed. After 45 days of study, a significant reduction in transaminases as well as an improvement in lipid profile in the S group was observed. Likewise, a significant reduction in the waist circumference of the S group was observed when compared with that of the C group, and increased glutathione and catalase levels associated with a reduction of lipid peroxidation. These results suggest that this is an effective dietary supplement for the prevention of cardiovascular diseases in individuals with metabolic syndrome.

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Section: Discussionsupporting

confidence: 84%

Lycium barbarumReduces Abdominal Fat and Improves Lipid Profile and Antioxidant Status in Patients with Metabolic Syndrome

Zanchet

Nardi

Bratti

et al. 2017

Oxidative Medicine and Cellular Longevity

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“…Similarly, the total cholesterol and TG of the rats fed diets enriched with Amazon fish decreased and the HDL of rats fed diets enriched with mapará and tambaqui increased -these fish contain omega-6 and omega-3 fatty acids. The plasma glucose levels did not differ significantly from those of the control group, which was also observed by Simão et al 31 and Wilkson et al 32 while supplementing a human diet with fish oil. Mortiz et al 33 stated that rats fed with chow enriched with fish oil tended to have lower blood glucose, total cholesterol, and LDL-c and higher TG than the control group.…”

Section: Discussionsupporting

confidence: 82%

Effect of fatty Amazon fish consumption on lipid metabolism

et al. 2014

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OBJECTIVE: The present study aimed to evaluate the effect of feeding diets enriched with fatty fish from the Amazon basin on lipid metabolism. METHODS: Male Wistar rats were divided into four groups: control group treated with commercial chow; Mapará group was fed diet enriched with Hypophthalmus edentatus; Matrinxã group was fed diet enriched with Brycon spp.; and, Tambaqui group was fed diet enriched with Colossoma macropomum. Rats with approximately 240g±0.60 of body weight were fed ad libitum for 30 days, and then were sacrificed for collection of whole blood and tissues. RESULTS: The groups treated with enriched diets showed a significant reduction in body mass and lipogenesis in the epididymal and retroperitoneal adipose tissues and carcass when compared with the control group. However, lipogenesis in the liver showed an increase in Matrinxã group compared with the others groups. The levels of serum triglycerides in the treated groups with Amazonian fish were significantly lower than those of the control group. Moreover, total cholesterol concentration only decreased in the group Matrinxã. High Density Lipoprotein cholesterol levels increased significantly in the Mapará and Tambaqui compared with control group and Matrinxã group. The insulin and leptin levels increased significantly in all treatment groups. CONCLUSION: This study demonstrated that diets enriched with fatty fish from the Amazon basin changed the lipid metabolism by reducing serum triglycerides and increasing high density lipoprotein-cholesterol in rats fed with diets enriched with Mapará, Matrinxã, and Tambaqui.

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“…demonstrated that the n-3 LC-PUFA did not increase the biomarkers of oxidative stress, such as 8-iso-PGF (2alpha) and 15-keto-dihydro PGF (2alpha) (9). DNA damage, such as that by 7, 8-dihydro-8-oxo-2’-deoxyguanosine in mildly hypertriacylglycerolemic patients (33), indicated that n-3 LC-PUFA-enriched products do not cause additional oxidative DNA damage as shown by the excretion of 7, 8-dihydro-8-oxo-2’-deoxyguanosine.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Fish Oil Supplementation on DNA Damage Induced by Cigarette Smoking

Ghorbanihaghjo

Safa

Alizadeh

et al. 2013

J Health Popul Nutr

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The study examined the influence of fish oil (FO) supplementation on serum 8-hydroxy-2’-deoxyguanosine (8-OHdG) levels as indicated by DNA damage markers and total antioxidant capacity (TAC) among male cigarette smokers. This double-blind, placebo-controlled randomized study was conducted among healthy cigarette smokers (n=40) who were part of a larger prospective cohort study. Twenty smokers were randomly selected to receive FO for 3 months (1 g/day), and another 20 smokers received a placebo for 3 months; 8-OHdG and TAC levels were measured in blood samples before and after the intervention. Serum 8-OHdG significantly decreased (p=0.001) and TAC increased (p<0.001) after 3 months of treatment with FO. Between baseline and endline, the difference in 8-OHdG significantly correlated with the difference in TAC among smokers who received FO (r=-0.540, p=0.014). The study provides evidence that FO supplementation can modify decreased antioxidants and increased oxidative DNA damage in cigarette smokers.

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Efeito dos ácidos graxos n-3 no perfil glicêmico e lipídico, no estresse oxidativo e na capacidade antioxidante total de pacientes com síndrome metabólica

Cited by 21 publications

References 37 publications

Lycium barbarumReduces Abdominal Fat and Improves Lipid Profile and Antioxidant Status in Patients with Metabolic Syndrome

Lycium barbarumReduces Abdominal Fat and Improves Lipid Profile and Antioxidant Status in Patients with Metabolic Syndrome

Effect of fatty Amazon fish consumption on lipid metabolism

Protective Effect of Fish Oil Supplementation on DNA Damage Induced by Cigarette Smoking

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