Absence of sibutramine effect on spontaneous anxiety in rats

Abstract

Introduction: Sibutramine has been described as a drug recommended for treatment of obesity, since it has the ability to inhibit the reuptake of serotonin and noradrenaline in the central nervous system, thereby increasing energy expenditure. Objective: Investigate the anxiogenic and anxiolytic effects of acute and chronic treatment with sibutramine in rats submitted to the task of the elevated plus-maze. Methods: Diazepam was used as a positive control for the anxiolytic effect, and the task of the elevated plus-maze showed sensitivity to detect the effect. In the chronic treatment, sibutramine was ingested for a period of two months. Results: The acute and chronic treatments at the studied dose, which is described to produce a maximum effect of anti-obesity in rats, did not interfere with anxiety. Conclusions: The acute and chronic administration of sibutramine is not related to anxiolytic or anxiogenic effects. Arq Bras Endocrinol Metab. 2010;54(4):375-80

Impact of loganin on pro-inflammatory cytokines and depression- and anxiety-like behaviors in male diabetic rats

“…In this study, EPM results showed that rats in the diabetic groups exhibited more entries into the closed arms and time spent in the closed arms, which were reversed by loganin treatment. Frassetto et al (14) used diazepam (1mg/kg) as a positive control in their study for its anxiolytic effect and showed that administration of diazepam increased the percentage of entries and time spent in the open arms when compared with diabetic rats. This study has failed to demonstrate this result and there was no apparent anxiolytic activity of diazepam in diabetic rats in EPM.…”

“…(ScienceLab, USA) (7), or diazepam (1 mg/kg i.p.) (Sigma, USA), 30 min before behavioral tests (14). The rats in the dia + log group received 40 mg/kg of loganin per os (Extrasynthese, France), which was administered at 9:00 a.m. for 10 consecutive days.…”

Concordance and incongruence in preclinical anxiety models: systematic review and meta-analyses

“…Fernandez et al, 2004;S. P. Fernandez et al, 2008;Flores et al, 2006;Fortes et al, 2013;Fraser et al, 2010;Frassetto et al, 2010;Galeotti et al, 2013;Girish et al, 2013;Gomes et al, 2010;Ma Eva Gonzalez-Trujano et al, 2006;Maria Eva Gonzalez-Trujano et al, 2015;González-Pardo et al, 2006;Griebel et al, 1998;1999a;1999b;Guilloux et al, 2013;Gupta et al, 2014;Han et al, 2009;Harada et al, 2006;Hasenohrl et al, 1996;Hazim et al, 2014;Huerta-Reyes et al, 2013;Hui et al, 2002;Ishaq, 2014;N. S. Jain et al, 2005;Jastrzebska-Wiesek et al, 2014;Jászberényi et al, 2009;Jessa et al, 1996;Jones et al, 1994;Kalouda and Pitsikas, 2015;Karakas et al, 2011;Karim et al, 2011;Kebebew and Shibeshi, 2013;Klodzinska et al, 2004a;2004b;Kong et al, 2006;Kumar and Bhat, 2014;Kurhe et al, 2014;Kuribara et al, 2000;la Pena et al, 2013;LaBuda and Fuchs, 2001;Langen et al, 2005;…”

“…We reviewed the available literature on diazepam for the three major rodent ARDEB assays: EPM, OF and LD. For the meta-analysis, data was Rodent anxiety meta-analyses page 11 extracted from a randomized subset of fifteen studies (out of 62 eligible papers) (Brioni et al, 1994;Faria et al, 1997;Boerngen-Lacerda and Souza-Formigoni, 2000;LaBuda and Fuchs, 2001;Hui et al, 2002;Chen et al, 2004;Jain et al, 2005;Jászberényi et al, 2009;Frassetto et al, 2010;Wanasuntronwong et al, 2012;Onusic et al, 2002;Birkett et al, 2011;Costa et al, 2011;Choleris et al, 2001;González-Pardo et al, 2006). Calculation of an average Hedges' g (Cumming, 2012) revealed that diazepam had a moderate effect on ARDEB, with a -0.89 g [95CI -1.12, -0.6] reduction compared with untreated control animals ( Figure 3).…”

Evaluation of the Effect of Acute Sibutramine in Female Rats in the Elevated T-Maze and Elevated Plus-Maze Tests

“…Its mechanism of action – similarly to tricyclic antidepressants – involves the blockade of the neuronal reuptake of serotonin and noradrenaline . Considering that tricyclic antidepressants, such as imipramine, are employed for the treatment of pathologies such as generalized anxiety disorder and panic disorder in human beings , it was previously investigated whether sibutramine would alter both anxiety‐ and panic‐related behaviours displayed by male rats submitted to animal tests of anxiety . Sibutramine did not affect the behaviour of male rats in the elevated plus‐maze (EPM), but it decreased the inhibitory avoidance in both light–dark transition test and elevated T‐maze (ETM) and impaired the escape response in the ETM .…”