O efeito da restrição calórica na longevidade

Genaro, Patrícia de Souza; Sarkis, Karin Sedó; Martini, Lígia Araújo

doi:10.1590/s0004-27302009000500019

Cited by 12 publications

(9 citation statements)

References 41 publications

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“…In relation to the high consumption of alcohol (34), claim that ethanol metabolism is involved in the depletion of the antioxidant system components and is directly linked to the generation of ROS and oxidative stress in the liver and decreases antioxidant capacity. In our study, the older group evidenced a lower alcohol intake than the others.…”

Section: Discussionmentioning

confidence: 99%

Oxidative Stress Function in Women over 40 Years of Age, Considering Their Lifestyle

Mota¹,

Santos²,

Soares³

et al. 2017

Front. Endocrinol.

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Aging is dependent on biological processes that determine the aging of the organism at the cellular level. The Oxidative Stress Theory of Aging might explain some of the age-related changes in cell macromolecules. Moreover, exposome and lifestyle may also induce changes in cell damage induced by oxidative stress. The aim of the present study was to analyze the related redox changes in lymphocyte function of healthy women over 40 years old. Three groups: younger (YG: 40–49 years), middle aged (MAG: 50–59 years), and older (OG: ≥60 years) were evaluated on anthropometric variables, blood pressure, cardiovascular fitness, lifestyle habits, perceived stress, DNA damage, malondialdehyde, catalase activity, and total antioxidant capacity. Physical activity and cardiovascular fitness were significantly higher in YG and MAG as compared to the OG. Systolic blood pressure increased significantly with group age. Frequency and total amount of alcohol intake were lower in the OG and higher in the MAG. No significant differences were observed between the three groups in oxidative stress parameters. Only alcohol consumption was associated with the higher DNA FPG-sensitive sites, and only in the YG (p < 0.05). Healthy lifestyle is critical to avoiding major ailments associated with aging. This may be inferred from the lack of significant differences in the various oxidative stress parameters measured in the healthy women over the age of 40 who took part in the study. Conscious lifestyle behaviors (decrease in alcohol and smoking habits) could have impaired the expected age-related oxidative stress increase.

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Section: Discussionmentioning

confidence: 99%

Oxidative Stress Function in Women over 40 Years of Age, Considering Their Lifestyle

Mota¹,

Santos²,

Soares³

et al. 2017

Front. Endocrinol.

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“…21,25,26 No presente estudo, os animais alimentados com "dieta da proteína" tiveram as maiores concentrações de interleucina-6, corroborando outros estudos, que mostraram que essas dietas estimulam a geração de um ambiente pró-inflamatório, aumentando a probabilidade de desenvolver doenças crônicas. 26,27 Conclusão O consumo da dieta da "proteína" pode causar aumento da pressão arterial sistólica, morfologia renal anormal, diâmetro e densidade volumétrica glomerular reduzidos, e aumento da produção de interleucina-6, um marcador inflamatório importante. Assim, este estudo sugere que a "dieta da proteína" leva a alterações no tecido renal, predispondo o indivíduo ao desenvolvimento de doenças crônicas.…”

Section: Densidade Volumétrica Glomerular (Vv)unclassified

A “Dieta Da Proteína” Reduz O Diâmetro E a Densidade Volumétrica Glomerular Em Ratas

Ribeiro

Pascoal²,

Castro³

et al. 2016

DEMETRA

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ARTIGOS DE TEMA LIVRE / FREE THEMED ARTICLES A "dieta da proteína" reduz o diâmetro e a densidade volumétrica glomerular em ratas The "protein diet" reduces diameter and glomerular volumetric density in rats Resumo Objetivo: O objetivo deste estudo foi avaliar o efeito do consumo da dieta da proteína na morfologia do tecido renal. Métodos: Quarenta Rattus Norvegicus wistar albino, adultas, foram divididas em quatro grupos (n=10): Controle 1 (C1), Controle 2 (C2), Hiperproteico 1 (HP1) e Hiperproteico 2 (HP2). Os grupos C2 e HP2 foram submetidos à restrição alimentar de 30%. Ao final do experimento, os rins foram retirados, pesados e seu comprimento e largura, aferidos. Posteriormente, foram clivados através do método orientator, fixados em formalina e incluídos em parafina. As lâminas dos cortes histológicos foram coradas pela técnica de Hematoxilina & Eosina e fotomicrografadas. A densidade volumétrica glomerular foi determinada por método estereológico, e o diâmetro dos glomérulos renais foi calculado com auxílio do software Image J. Análises séricas foram realizadas pelo método colorimétrico. Os resultados são expressos como média e desvio padrão. Para comparação das médias entre os grupos, foram utilizados ANOVA e Tukey como pós-teste, aceitando nível de significância de 5%. Resultados: Os grupos hiperproteicos apresentaram maior pressão arterial. O tamanho e peso renal do grupo HP1 foram maiores do que C1 e C2. O grupo HP1 mostrou diâmetro glomerular inferior e o grupo HP2 mostrou densidade volumétrica glomerular inferior aos grupos C1 e C2. Conclusão: A "dieta da proteína" pode causar aumento da pressão arterial sistólica, morfologia renal anormal, redução do diâmetro e na densidade volumétrica glomerular. Assim, o estudo sugere que essa dieta possa levar a alterações no tecido renal, predispondo ao desenvolvimento de doenças crônicas.

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“…A level of CR between 20 and 40% without compromising the ingestion of essential nutrients (Genaro et al 2009;Cantó and Auwerx 2009) can preserve the ovarian reserve in female mice and rats (Shi et al 2013;Li et al 2015). Eight week old female mice on CR maintain an increased proportion of primordial follicles, indicating decreased follicle activation and a threefold increase in expression of AMH (Shi et al 2013), a common marker of ovarian reserve (Broer et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Effect of caloric restriction and rapamycin on ovarian aging in mice

et al. 2019

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Caloric restriction (CR) increases the preservation of the ovarian primordial follicular reserve, which can potentially delay menopause. Rapamycin also increases preservation on the ovarian reserve, with similar mechanism to CR. Therefore, the aim of our study was to evaluate the effects of rapamycin and CR on metabolism, ovarian reserve, and gene expression in mice. Thirty-six female mice were allocated into three groups: control, rapamycin-treated (4 mg/kg body weight every other day), and 30% CR. Caloric restricted females had lower body weight (P < 0.05) and increased insulin sensitivity (P = 0.003), while rapamycin injection did not change body weight (P > 0.05) and induced insulin resistance (P < 0.05). Both CR and rapamycin females displayed a higher number of primordial follicles (P = 0.02 and 0.04, respectively), fewer primary, secondary, and tertiary follicles (P < 0.05) and displayed increased ovarian Foxo3a gene expression (P < 0.05). Despite the divergent metabolic effects of the CR and rapamycin treatments, females from both groups displayed a similar increase in ovarian reserve, which was associated with higher expression of ovarian Foxo3a.

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O efeito da restrição calórica na longevidade

Cited by 12 publications

References 41 publications

Oxidative Stress Function in Women over 40 Years of Age, Considering Their Lifestyle

Oxidative Stress Function in Women over 40 Years of Age, Considering Their Lifestyle

A “Dieta Da Proteína” Reduz O Diâmetro E a Densidade Volumétrica Glomerular Em Ratas

Effect of caloric restriction and rapamycin on ovarian aging in mice

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