Consumo alimentar e dislipidemia decorrente da terapia antirretroviral combinada para infecção pelo HIV: uma revisão sistemática

Almeida, Luara Bellinghausen; Giudici, Kelly Virecoulon; Jaime, Patrícia Constante

doi:10.1590/s0004-27302009000500005

“…Uma revisão sistemática evidenciou insuficiente relação entre o consumo alimentar e a alteração do perfil em pacientes infectados pelo HIV em uso de antirretrovirais; talvez esse resultado tenha ocorrido devido a metodologias diferentes empregadas nos estudos 30 .…”

Section: Discussionunclassified

Lipodystrophy syndrome and cardiovascular risk factors in children and adolescents infected with HIV/AIDS receiving highly active antiretroviral therapy

Werner¹,

Pone²,

Fonseca³

et al. 2010

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Objective: To describe lipid profile, body shape changes, and cardiovascular risk factors in children and adolescents infected with HIV/AIDS receiving highly active antiretroviral therapy. Methods:We investigated 43 children and adolescents being treated with this therapy at the outpatient clinic of pediatric infectious diseases of Instituto Fernandes Figueira/Fundação Oswaldo Cruz, Rio de Janeiro, Brazil. Values of total cholesterol, high-density lipoprotein, low-density lipoprotein, and triglycerides were determined. We also performed glucose tolerance test and analyzed body fat distribution, nutritional status, dietary intake, and family history of cardiovascular risk. The statistical analysis was performed using Student's t test. Significance level of pvalue was lower than 0.05. Results:We found lipid abnormality in 88.3% and body shape change in 13.9% of the cases. Nutritional status was adequate (81.3%) in most of the study population. Cholesterol intake in children older than 9 years was above the recommended value. Conclusion:Prevalence of dyslipidemia and, therefore, risk for cardiovascular diseases were high during the use of highly active antiretroviral therapy.J Pediatr (Rio J). 2010;86(1):27-32: Lipodystrophy, HIV, cardiovascular diseases, children, adolescents. ResumoObjetivo: Descrever o perfil lipídico, alterações da conformação corporal e fatores de risco cardiovasculares em crianças e adolescentes infectados pelo HIV/AIDS, tratados com terapia antirretroviral de alta potência. Métodos:Foram estudadas 43 crianças e adolescentes em uso dessa terapia atendidas no ambulatório de doenças infecciosas em Pediatria do Instituto Fernandes Figueira/Fundação Oswaldo Cruz, Rio de Janeiro (RJ). Foram realizadas dosagens de colesterol total, lipoproteína de alta densidade, lipoproteína de baixa densidade, triglicerídeos, teste de tolerância à glicose e avaliada a distribuição de gordura corporal, estado nutricional, ingestão dietética e história familiar de risco cardiovascular. As análises estatísticas foram realizadas com o teste t de Student. O nível de significância estatístico do p foi menor que 0,05.Resultados: Observou-se alteração lipídica em 88,3% e de conformação corporal em 13,9% dos casos. O estado nutricional foi adequado na maioria (81,3%) da população do estudo. A ingestão de colesterol em crianças com mais de 9 anos foi acima do recomendado. Conclusão:A prevalência de dislipidemia e, consequentemente, o risco para doenças cardiovasculares foram altos durante o uso de terapia antirretroviral de alta potência.

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“…Such a finding may be a consequence of the different methods used in the studies. 30 The fiber intake found in those patients older than 9 years old was below the recommended value for their age, and this was another factor contributing to the increase in the level of serum cholesterol, since, once fibers reach the bowels, they can attach to certain substances, such as cholesterol, reducing their absorption. The influence of the eating habits on metabolic complications associated with HIV infection has not been widely studied.…”

Section: Discussionmentioning

confidence: 99%

Síndrome da lipodistrofia e fatores de risco cardiovasculares em crianças e adolescentes infectados pelo HIV/AIDS em uso de terapia antirretroviral de alta potência

Werner

¹

,

Pone

²

,

Fonseca

³

et al. 2010

J. Pediatr. (Rio J.)

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Objective: To describe lipid profile, body shape changes, and cardiovascular risk factors in children and adolescents infected with HIV/AIDS receiving highly active antiretroviral therapy. Methods:We investigated 43 children and adolescents being treated with this therapy at the outpatient clinic of pediatric infectious diseases of Instituto Fernandes Figueira/Fundação Oswaldo Cruz, Rio de Janeiro, Brazil. Values of total cholesterol, high-density lipoprotein, low-density lipoprotein, and triglycerides were determined. We also performed glucose tolerance test and analyzed body fat distribution, nutritional status, dietary intake, and family history of cardiovascular risk. The statistical analysis was performed using Student's t test. Significance level of pvalue was lower than 0.05. Results:We found lipid abnormality in 88.3% and body shape change in 13.9% of the cases. Nutritional status was adequate (81.3%) in most of the study population. Cholesterol intake in children older than 9 years was above the recommended value. Conclusion:Prevalence of dyslipidemia and, therefore, risk for cardiovascular diseases were high during the use of highly active antiretroviral therapy.

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“…The follow-up time is an important point to be considered due to the behavioral component of the dietary intervention and the variability between a change in the food consumption level and its impact on metabolic outcomes 20 .…”

Section: Discussionmentioning

confidence: 99%

The effects of a diet formulation with oats, soybeans, and flax on lipid profiles and uricemia in patients with AIDS and dyslipidemia

Ferreira

¹

,

Cassaro

²

,

Domingos

³

et al. 2013

Rev. Soc. Bras. Med. Trop.

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Revista da Sociedade Brasileira de Medicina Tropical 46(6):691-697, Nov-Dec, 2013http://dx.doi.org/10.1590/0037-8682-0087-2013 INTRODUCTION ABSTRACT Introduction:Although the initiation of highly active antiretroviral therapy (HAART) is accompanied by an attenuation of viral load, metabolic disorders characterized by hyperglycemia, dyslipidemia, and lipodystrophy are often observed in patients under this treatment. Certain foods, such as oat bran, soy protein, and fl axseed, have been shown to improve a patient's lipid profi le despite possible increases in uricemia. Thus, a bioactive compound was formulated using these foods to help patients with HIV/ AIDS control metabolic disorders resulting from HAART. Methods: An uncontrolled before and after study was performed. The total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides, and uric acid before and after 3 months of consuming the formulation were compared in patients. The compound was formulated such that 40g (the recommended daily intake) contained approximately 10g of fl axseed, 20g of oat bran, and 10g of textured soy protein. Results: The study population consisted of 139 patients, 31 of whom were included in the fi nal analysis. There were no signifi cant variations between the laboratory results obtained before and after consumption of the compound. Conclusions: The regular consumption of the formulation together with individualized dietary guidance did not reduce lipid levels and did not contribute to an increase in uricemia in the study group. However, new studies with higher doses of the foods that compose the formulation should be encouraged to investigate whether these foods can positively infl uence the lipid profi les of these patients.

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Consumo alimentar e dislipidemia decorrente da terapia antirretroviral combinada para infecção pelo HIV: uma revisão sistemática

Cited by 19 publications

References 35 publications

Lipodystrophy syndrome and cardiovascular risk factors in children and adolescents infected with HIV/AIDS receiving highly active antiretroviral therapy

Lipodystrophy syndrome and cardiovascular risk factors in children and adolescents infected with HIV/AIDS receiving highly active antiretroviral therapy

Síndrome da lipodistrofia e fatores de risco cardiovasculares em crianças e adolescentes infectados pelo HIV/AIDS em uso de terapia antirretroviral de alta potência

The effects of a diet formulation with oats, soybeans, and flax on lipid profiles and uricemia in patients with AIDS and dyslipidemia

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