Iodine nutrition: more is better?

Camargo, Rosalinda; Knobel, Meyer; Medeiros‐Neto, Geraldo

doi:10.1590/s0004-27302007000400021

Cited by 7 publications

(6 citation statements)

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“…[43][44][45][46] Recently, researchers have warned of the higher risk of autoimmune thyroiditis in Brazilian people due to the higher consumption of iodine. 47,48 In 2001, the "Thyromobil" study showed very high levels of urinary iodine among the Brazilians (68% had levels of urinary iodine above 300 g/L). In the state of Minas Gerais, 100% of the samples had ioduria above 300 g/L (median of 500 g/L).…”

Section: Discussionmentioning

confidence: 99%

Autoimmune Thyroiditis and Rheumatoid Arthritis

Gonçalves¹,

Feibelmann²,

Ranza³

et al. 2009

The Endocrinologist

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Section: Discussionmentioning

confidence: 99%

Autoimmune Thyroiditis and Rheumatoid Arthritis

Gonçalves¹,

Feibelmann²,

Ranza³

et al. 2009

The Endocrinologist

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“…[15] Among them, the incidence of thyroid malignancies which is most harmful to human beings annually increase of 14.51%, [16] and is believed to be caused by excessive iodine intake. However, this conclusion has been controversial [17]. This study shows that a high concentration of iodine is one of the risk factors of thyroid disease.…”

Section: Discussionmentioning

confidence: 78%

The Risk Assessment of Thyroid Disorders Based on Metabonomics

Bai¹,

Liu²,

Liu³

et al. 2021

Preprint

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BackgroundWhen thyroid disorders occurred, it can disturb the balance of trace elements in human body. Therefore, the detection of trace elements during an early screening of thyroid diseases, treatment, and prognosis judgment based on personal characteristics of drugs and treatment will provide a scientific basis for clinical decision-making and can effectively reduce patients' pain and social medical burden. Methods50 healthy volunteers and 200 patients with thyroid diseases (58 cases of thyroid nodule, 59 cases of goiter, 34 cases of postoperative thyroid cancer and 24 cases of thyroid cancer) were compared in our study. Total trace elements of iodine, selenium, manganese, chromium etc. (in total 28 elements) in human serum were detected by inductively coupled plasma mass spectrometry (ICP-MS). A risk assessment model for thyroid disease was established after analyzing trace elements content, thyroid function and ultrasonography results by gender and age with the characteristics of the Chinese population. ResultsThe results showed there were significant differences in eight trace elements (I, Ca, Fe, Ni, Cu, Zn, Se, Sb) between the thyroid disease group and the healthy control group (P < 0.05). There were significant differences in ten trace elements (I, Ca, Cr, Mn, Co, Ni, Cu, Zn, Se, Sb) between the female thyroid disease group and the control group (P< 0.05). And there were significant differences in the eight trace elements (I, Mn, Fe, Ni, Cu, Zn, Se, Sb) between the male thyroid disease group and the control group (P< 0.05). There were significant correlations between the contents of FT3, FT4, T3 and T4 corresponding to iodine (P< 0.05) in thyroid disease group. Also, correlations between Fe-Zn, Cr-Mn, Ca-Zn, Ca-Se, Ca-Fe and Zn-Se (P<0.05) were found in thyroid disease group too. ConclusionsThe high concentration of iodine and manganese are risk factors of thyroid disease. In addition to the low concentration of cobalt, nickel, copper, zinc, selenium, and antimony, calcium in the serum of female patients with thyroid disease and iron in the serum of male patients with thyroid disease play a very important role. Random forest model based on element risk assessment of thyroid disease is helpful for the diagnosis and treatment of thyroid disease.

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“…8,11 This has sparked debate as to whether iodide intakes of 300-400 g per day should be considered excessive or adequate. 12,13 To compound the issue, the amount of iodine in individual foods and water can vary by a factor of 100, 14,15 rendering quantitation of iodide intake extremely difficult. Thus, values of the median urinary excretion rate above 300 g I/l have been considered as indices of excessive iodide intake associated with increased risk of hypothyroidism.…”

Section: A Introductionmentioning

confidence: 99%

“…Thus, values of the median urinary excretion rate above 300 g I/l have been considered as indices of excessive iodide intake associated with increased risk of hypothyroidism. 13 Despite several studies (reviewed in 8,10), it remains unknown if and how iodide intake, at dietary levels close to the tolerable limits, influences development of autoimmune thyroiditis in euthyroid individuals over long time periods, and animal models of autoimmune thyroiditis have not yet addressed this issue. It appears likely, however, that due to genetic factors, general recommendations may not be equally applicable to various populations and different countries of the world.…”

Section: A Introductionmentioning

confidence: 99%

“…It appears likely, however, that due to genetic factors, general recommendations may not be equally applicable to various populations and different countries of the world. 13 Within an immunological context, iodine may mediate thyroiditis induction via at least two mechanisms: a) by increased post-translational modification of thyroglobulin (Tg), an event which may enhance the immunopathogenicity of this molecule as detailed further in this review; and b) via apoptotic/necrotic effects of thyrocytes, a step that could initiate presentation of thyroid antigens at immunostimulatory levels. This review summarizes recent findings related to these issues with emphasis on Tg immunogenicity, as this has been more extensively studied.…”

Section: A Introductionmentioning

confidence: 99%

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Molecular parameters linking thyroglobulin iodination with autoimmune thyroiditis

Carayanniotis¹

2011

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Increased iodide intake has been linked to the development of hypothyroidism and/or autoimmune thyroiditis in humans and animals, but the mechanisms involved remain poorly understood. Increased ingestion of iodide is likely to have pleiotropic effects on either metabolic or immunological processes. Within the latter domain, recent interest has been focused on two areas: a) the role of iodinated peptides in thyroglobulin (tg)-the molecular site of biosynthesis and storage of iodotyrosines and iodothyronines-in triggering an autoimmune cascade, and b) the role of iodine-induced apoptosis/necrosis of thyrocytes in the disease process. this review presents a brief summary of recent findings in these research areas.

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Iodine nutrition: more is better?

Cited by 7 publications

References 5 publications

Autoimmune Thyroiditis and Rheumatoid Arthritis

Autoimmune Thyroiditis and Rheumatoid Arthritis

The Risk Assessment of Thyroid Disorders Based on Metabonomics

Molecular parameters linking thyroglobulin iodination with autoimmune thyroiditis

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