Resistência insulínica e perfil metabólico em pacientes com síndrome dos ovários policísticos de peso normal e sobrepeso/obesidade

Abstract

RESUMOObjetivo: Avaliar a sensibilidade insulínica e o perfil metabólico em portadoras de SOP com peso normal e sobrepeso/obesas. Material e Méto-dos: Foram avaliadas, retrospectivamente, 49 pacientes, entre 18 e 45 anos, divididas em 2 grupos, conforme o índice de massa corporal (IMC): grupo 1 (18,5-24,9 kg/m 2 ) e grupo 2 (25-40 kg/m 2 ). Dados coletados: pressão arterial sistólica (PAS) e diastólica (PAD); valores basais e após TOTG da glicose, insulina, e da relação glicose/insulina; área sob a curva para glicose e insulina; HOMA-IR, HOMA-β; perfil lipídico; testosterona total (T) e livre (TL (49) patients from 18 to 45 years were retrospectively evaluated and divided into 2 groups, according to the body mass index (BMI): group 1 (18.5-24.9 kg/m 2 ) and group 2 (25-40 kg/m 2 ). Colected data: systolic and dyastolic blood pressure; fasting and after OGTT glucose, insulin and glucose/insulin ratio; area under the curve for glucose and insulin; HOMA-IR and HOMA-β; lipidic profile; free (FT) and total testosterone (T) levels. Results: Greater averages of pressoric levels, insulin resistance (IR) indices, triglycerides and the FT levels, in adition to lower HDL levels, were found in group 2. Neither correlation between the IMC with none of data nor of the FT and IR indices with the lipid profile were found. Conclusions: Obesity is associated with insulin resistance and diabetes mellitus in PCOS, independently on familiar history of DM. The absence of correlation between the IR indices and the FT with the lipidic profile suggests that other factors, such as the free fatty acids, can be involved in the pathogenesis of dyslipidemia in PCOS.

Upper trunk fat assessment and its relationship with metabolic and biochemical variables and body fat in polycystic ovary syndrome

“…In addition to its classical characteristics (menstrual irregularity of the oligo/amenorrhea type, chronic anovulation, infertility, and clinical and/or laboratory hyperandrogenism) (Nacul et al. , 2003; Kuba et al. , 2006; Speca et al.…”

“…Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women, affecting 6-10% of women of reproductive age (Asuncion et al, 2000). In addition to its classical characteristics (menstrual irregularity of the oligo/amenorrhea type, chronic anovulation, infertility, and clinical and/or laboratory hyperandrogenism) (Nacul et al, 2003;Kuba et al, 2006;Speca et al, 2007), this syndrome is also associated with several features of metabolic syndrome, such as obesity, abdominal obesity (Kirchengast & Huber, 2001) and insulin resistance (IR) (Dunaif et al, 1989;Dunaif, 1997). Women with PCOS tend to accumulate more upper body fat than women without the syndrome matched for weight and age (Douchi et al, 1995;Kirchengast & Huber, 2001;Cascella et al, 2008;Svendsen et al, 2008), a fact that places the former population at increased risk of developing metabolic complications such as IR and of presenting cardiovascular risk factors (Barber et al, 2006).…”

Avaliação do efeito hipoglicemiante de Cissus sicyoides em estudos clínicos fase II

“…O HOMA B do G1 foi 144,2 e o do G2 foi de 265 (Kuba et al, 2006). A variação espontânea da glicemia apresentou redução da glicemia quando as pacientes ingeriram o chá; apesar de a maior diferença ter ocorrido 1 hora após a ingestão do mesmo, essa diferença não foi signifi cativa em nenhum dos tempos (Tabela 3).…”

Treadmill walking differently affects body composition and metabolic parameters of female rats from normal or small litters

“…It has to be noted, however, that there was a consistent and significant decrease of the retroperitoneal adipocyte diameter in the exercised groups (CE and SE). As visceral fat is associated with the changes in peripheral and hepatic insulin sensitivity seen in obesity (5,15,29,49), the reduced size of retroperitoneal adipocytes promoted by treadmill walking may be relevant.…”

“…Obesity in human populations and several rodent models is associated with insulin resistance and glucose intolerance (7,29,42). In these instances, it is expected as follows: 1) higher fasting blood glucose, 2) greater blood glucose increase and lower rate of decay after oral administration of glucose, and 3) lower decrease of blood glucose after insulin administration.…”