Bisphosphonates

McClung, Michael R.

doi:10.1590/s0004-27302006000400018

Cited by 27 publications

(40 citation statements)

References 93 publications

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“…Moreover, it is important to know how is the absorption and bioavailability of drugs, such as oral bisphosphonates, which may be compromised in bariatric surgery 37 . Bisphosphonates are drugs that inhibit osteoclasts and are prescribed to patients with an imbalance in bone metabolism leading to osteoporosis 33 . Another consequence often found in people who have undergone Roux-en-Y gastric bypass, is the chronic regurgitation or gastroesophageal reflux; it may be due to the narrow diameter of the silicone ring and also hypotonicity of the lower esophageal sphincter 1 .…”

Section: Methodsmentioning

confidence: 99%

Consequências sistêmicas da cirurgia bariátrica e suas repercussões na saúde bucal

Moura-Grec

Assis

Cannabrava

et al. 2012

ABCD, arq. bras. cir. dig.

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-Introduction -Morbid obesity control can be done by bariatric surgery that restricts or reduces the amount of food absorption. The objective of this review was to identify the consequences of bariatric surgery and its repercussions on oral health. Method -It was used the Virtual Library of Health, which included articles that had any direct or indirect connection between bariatric surgery and oral health, and published in the last ten years. Results -Some complications of the surgery are chronicle reflux and nutritional deficiency, which may bring repercussions on the oral cavity, such as tooth erosion, bone loss and dental caries. On the other hand, there are also positive impacts, such as the decrease of diabetes, apnea and improvement on self-esteem, that makes the patients less vulnerable to complications regarding oral health, for example xerostomy and periodontal disease. Conclusion -Maintaining proper oral health in patients undergoing bariatric surgery contributes to success after surgery protecting benefits and minimizing side effects. ABCDDV/868RESUMO -Introdução -O controle da obesidade mórbida pode ser realizado através da cirurgia bariátrica que leva à restrição e/ou à má-absorção de alimentos. O objetivo dessa revisão foi identificar consequências desse procedimento e suas repercussões na saúde bucal. Método -Foi realizada busca na Biblioteca Virtual em Saúde, sendo incluídos artigos com relação direta ou indireta entre cirurgia bariátrica e saúde bucal e publicados nos últimos dez anos. Resultados -Verificaram-se algumas complicações decorrentes dessa operação, como regurgitação crônica e deficiências nutricionais, que podem trazer repercussões na cavidade bucal como erosão dentária, perda óssea e cárie dentária. Por outro lado, existem consequências positivas como controle da diabetes, da apnéia e melhora da auto-estima, que tornam os pacientes menos susceptíveis à complicações na cavidade oral, como xerostomia e doença periodontal. Conclusão -A manutenção da saúde bucal adequada em pacientes submetidos à cirurgia bariátrica contribui para o sucesso após a operação, resguardando os benefícios e minimizando os efeitos colaterais.

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Section: Methodsmentioning

confidence: 99%

Consequências sistêmicas da cirurgia bariátrica e suas repercussões na saúde bucal

Moura-Grec

Assis

Cannabrava

et al. 2012

ABCD, arq. bras. cir. dig.

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“…The pathogenesis is still unknown. Although hypothesized as a possible etiology to the problem stronger reduced bone turnover could not be demonstrated in these patients as a risk factor (30).…”

Section: Bisphosphonates -Side Effectsmentioning

confidence: 79%

“…Gastrointestinal (GI) symptoms are the most frequent side effects attributed to bisphosphonate use. They occur in about 20%-30% of the patients, usually within the first weeks of therapy (30). Experimental studies have previously demonstrated that these drugs are able to promote upper gastrointestinal injury, especially in the context of preexisting esophageal irritation, Arq Bras Endocrinol Metab.…”

Section: Bisphosphonates -Side Effectsmentioning

confidence: 99%

“…Inflammation of ocular structures, allergic manifestations, and abnormal tests of liver function have been reported. These effects are generally mild and self-limited (30). For some intravenously administered bisphosphonates renal toxicity has been described (36), suggesting the need for renal function testing before and during treatment, dose reductions for mild-to-moderate renal impairment, and caution for patients with severe renal dysfunction.…”

Section: Bisphosphonates -Side Effectsmentioning

confidence: 99%

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Bisphosphonates in the treatment of metabolic bone diseases

Arantes

Silva

Lazaretti‐Castro

2010

Arq Bras Endocrinol Metab

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SUMMARYOsteoporosis is a disease characterized by low bone mass associated with the deterioration of microarchitecture, due to an imbalance either in high bone resorption or low bone formation or in both, leading to a high risk of fractures. Bisphosphonates are medications which reduce the ability of osteoclasts to induce bone resorption and consequently improve the balance between resorption and formation. There are bisphosphonates approved for the prevention and treatment of osteoporosis. Administration can be oral (daily, weekly or monthly) or intravenous (quarterly or yearly). These medications are well tolerated and with the correct instructions of administration have a good safety profile. Serious side effects, such as, osteonecrosis of jaw is very rare. Bisphosphonates are the most prescribed medication for the treatment of osteoporosis. Arq Bras Endocrinol Metab. 2010;54(2):206-12 Keywords Bisphosphonates; mechanism of action; osteoporosis treatment; side effects SUMÁRIO Osteoporose é uma doença caracterizada por baixa massa óssea associada à deterioração da microarquitetura devido ao desbalanço pela alta reabsorção, baixa formação ou ambas, levando a um alto risco de fraturas. Bisfosfonatos são medicamentos que reduzem a capacidade de os osteoclastos induzirem a reabsorção óssea e, consequentemente, melhorar o balanço entre reabsorção e formação. Há bisfosfonatos aprovados para prevenção e tratamento da osteoporose. A administração pode ser via oral (diária, semanal ou mensal) ou intravenosa (trimestral ou anual). Essas medicações são bem toleradas e, seguindo as recomendações adequadas, apresentam alto grau de perfil de segurança. Efeitos colaterais sérios, como osteonecrose de mandíbula, são raros. Bisfosfonatos são as medicações mais prescritas para o tratamento da osteoporose. Arq Bras Endocrinol Metab. 2010;54(2):206-12 Descritores Bisfosfonatos; mecanismo de ação; tratamento da osteoporose; efeitos colaterais

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“…BPs have been successfully used as a treatment option in skeletal disorders including post-menopausal and corticosteroid-induced osteoporosis [13] and Paget's bone disease [14]. Intravenous or oral administration of BPs is commonly used in oncology as a skeletal protector against hypercalcemia and/or bone metastases in cases of multiple myeloma, breast, prostate or other cancers [4].…”

Section: Discussionmentioning

confidence: 99%

Lip Ulceration Associated with Intravenous Administration of Zoledronic Acid: Report of a Case

Andreadis

Mauroudis

Poulopoulos

et al. 2011

Head and Neck Pathol

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Although osteonecrosis of the jaw is a wellknown adverse reaction of bisphosphonates (BPs), random cases of oral mucosal ulceration after per os administration of BP-aledronate have been attributed to prolonged mucosal irritation. This report, for the first time, describes the mucosal ulceration related to intravenous use of zoledronic acid (ZA). A 52-year-old female patient presented with painful ulcers on both cutaneous/mucosal surfaces of the lower lip and a 2-month history of osteonecrosis of the mandible beside the right lower canine. Her medical record included intravenous administration of ZA for 10 months for primary breast cancer metastatic to bone. Examination of the peripheral blood showed severe anemia and a slightly increased white blood cell count, due to urinary tract infection by E. coli, but no evidence of a viral infection. The treatment of anemia and E. coli infection did not improve the labial ulcers. Biopsy from the mucosal lesion revealed a nonspecific ulceration with moderate inflammatory infiltration. There was no evidence of infection or malignancy. ZA administration was discontinued and within 3 months the lesions were resolved after treatment with systemic antibiotics (amoxicillin), vitamins A and E, chlorexidine and H 2 O 2 (hydrogen peroxide) solutions and local pantothenic acid/ vitamin A creams. Recurrence was detected a month after ZA re-administration. Nevertheless, after new treatment, the patient was free of oral/skin lesions 18 months later. This case, which is the first report of ulceration associated with intravenous administration of bisphosphonates, suggests that systemic mechanisms may be implicated in BP-induced oral mucosal ulceration. Furthermore, ZA appears to cause the same oral mucosal manifestations as alendronate. This emphasizes the need for oral examination in all cases of BP therapy, whether per os or intravenously administrated.

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Bisphosphonates

Cited by 27 publications

References 93 publications

Consequências sistêmicas da cirurgia bariátrica e suas repercussões na saúde bucal

Consequências sistêmicas da cirurgia bariátrica e suas repercussões na saúde bucal

Bisphosphonates in the treatment of metabolic bone diseases

Lip Ulceration Associated with Intravenous Administration of Zoledronic Acid: Report of a Case

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