Relation between insulin resistance and hematological parameters in a Brazilian sample

Ellinger, Vivian; Carlini, Ludmila T.; Moreira, Rodrigo O.; Meirelles, Ricardo M.R.

doi:10.1590/s0004-27302006000100016

Cited by 27 publications

(22 citation statements)

References 14 publications

(15 reference statements)

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“…It has been reported previously that elevated HCT levels are a predictor of insulin resistance and metabolic syndrome, which are closely related to NAFLD [7][8][9]. Our data are consistent with what has been reported previously [7][8][9][10][11].…”

Section: Discussionsupporting

confidence: 93%

“…Our data are consistent with what has been reported previously [7][8][9][10][11]. However, the mechanism by which elevated HCT level is associated with NAFLD is not well understood; there are several possible explanations.…”

Section: Discussionsupporting

confidence: 93%

“…Hematological parameters including red blood cell (RBC) count, hematocrit (HCT), and hemoglobin (HGB) are also known to be independently associated with insulin resistance [7][8][9] and NAFLD [10] in diverse populations. Li et al [11] reported that the prevalence of NAFLD is positively associated with HCT levels in Hunan, China.…”

Section: Introductionmentioning

confidence: 99%

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Association between Hematocrit Level and the Development of Non-Alcoholic Fatty Liver Disease in Chinese Adults: A 5-Year Study

Liu¹,

Liang²,

Qiu³

et al. 2017

J Metabolic Synd

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Non-alcoholic fatty liver disease (NAFLD) is recognized as a major cause of liver-related morbidity and mortality. The aim of this study was to examine the longitudinal association between baseline hematocrit (HCT) level and the development of NAFLD in Chinese adults. We performed a prospective cohort study of 2798 healthy Chinese adults without NAFLD at baseline. A Cox proportional hazards model was used to determine hazard ratios for NAFLD incidence in two groups determined by baseline hematocrit levels (group A, HCT <49%; group B, HCT ≥ 49%). During 10346.5 person-years of follow-up, 474 (16.9%) NAFLD cases developed between 2008 and 2012. After adjusting for multiple covariates and change in the covariates during the follow-up period, the hazard ratios (95% confidence interval) for NAFLD incidence when comparing group B with group A were 1.17 (1.03-1.31) and 1.70 (1.26-2.31), respectively (p<0.001). Conclusions:HCT level may be a predictor of the development of NAFLD in Chinese adults.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

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Association between Hematocrit Level and the Development of Non-Alcoholic Fatty Liver Disease in Chinese Adults: A 5-Year Study

Liu¹,

Liang²,

Qiu³

et al. 2017

J Metabolic Synd

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“…56,57 It has already been demonstrated that IR and hyperinsulinaemia are associated with the stimulation of erythroid progenitors and increased levels of inflammatory markers. 58,59 Low-dose aspirin still remains the major antiplatelet therapy by reducing the risk of heart attack, stroke or cardiovascular death in intermediate to high risk patients with established vascular disease by up to about 20%. 35 Even with this intervention, some patients' platelets still remain activated when assessed, despite aspirin therapy.…”

Section: Markers Of Blood Coagulation Plasma Plateletsmentioning

confidence: 99%

Diabetes mellitus: A review of some of the prognostic markers of response to treatment and management

Agu

2018

JMH

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Background: The WHO defined ‘diabetes mellitus’ (DM) as a metabolic disorder characterised by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from the defect in insulin secretion, or inaction, or both. When not identified early and controlled, acute and chronic life-threatening consequences may result. Identifying DM early for treatment and management, as well as clinically monitoring recovery and improvement during treatment, involves the assessments of biomarkers. The types, choice, sensitivity and descriptive information trends of these biomarkers are very important. Aim: Some prognostic biomarkers and parameters that this review identified include glycated haemoglobin, white blood cells, mean neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, total leukocytes and neutrophils, plasma low-density lipoprotein, high-density lipoprotein and very low-density lipoprotein, platelet, fibrinogen, D-dimer and C-reactive proteins. Results: These parameters display increases in DM, while red blood cell, haemoglobin concentration, activated partial thromboplastin time, prothrombin time and partial thromboplastin time are decreased. Conclusion: With sound knowledge of the variations of these markers and parameters, observed reversal during treatment and management of DM and its complications can be better monitored, and guided decisions can be made.

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“…Recent studies have shown that pre-hypertension or hypertension plays a very important role in atherosclerosis, cardiovascular disease (CVD), and deaths [3][4][5][6][7][8]. Hematological parameters that include red blood cell (RBC) count, hematocrit (HCT), and hemoglobin (HB) were independently associated with insulin resistance [9][10][11] and incidents of type 2 diabetes [12] in diverse populations. Wu et al [13] reported that three erythrocyte parameters (RBC, HB, and HCT) were found to be associated with hypertension in their cohort study.…”

Section: Introductionmentioning

confidence: 99%

Association of Hematocrit and Pre-hypertension Among Chinese Adults: The CRC Study

Liu

Liang

Qiu

et al. 2014

Cell Biochem Biophys

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Elevated blood pressure is regarded as an independent risk factor for cardiovascular diseases and diabetes. We examined the relation between hematocrit and pre-hypertension as well as the effect of sex, obesity, fasting glucose, and lipids in Chinese adults. The study samples were from a community-based health examination survey in China and included a total of 2,3691 patients with blood pressure in normal range. The odds ratios [ORs, 95 % confidence interval (CI)] of pre-hypertension across increasing quartiles of hematocrit were 1.000, 1.176 (1.050-1.318), 1.213 (1.081-1.363), and 1.364 (1.209-1.540) (P for trend < 0.001), when adjusted for age, sex, body mass index, glutamic-pyruvic transaminase, glutamic-oxalocetie transaminase, serum uric acid, glucose, and lipids. Associations were significant in both men and women, but not in individuals older than 60 years. In addition, low-density lipoprotein cholesterol significantly interacted with hematocrit (P for interaction <0.024). The associations were more evident in patients with low (P < 0.001) and median LDL-C levels (P < 0.013) than those with high glucose levels. Hematocrit was associated with pre-hypertension, and was independent of metabolic risk factors. These associations were not significant in older individuals and low-density lipoprotein cholesterol may modify these associations.

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Relation between insulin resistance and hematological parameters in a Brazilian sample

Cited by 27 publications

References 14 publications

Association between Hematocrit Level and the Development of Non-Alcoholic Fatty Liver Disease in Chinese Adults: A 5-Year Study

Association between Hematocrit Level and the Development of Non-Alcoholic Fatty Liver Disease in Chinese Adults: A 5-Year Study

Diabetes mellitus: A review of some of the prognostic markers of response to treatment and management

Association of Hematocrit and Pre-hypertension Among Chinese Adults: The CRC Study

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