Prevalência de auto-imunidade tireoidiana em um grupo de pacientes com diabetes mellitus tipo 1 em Londrina, PR

Souza, Otton Luis Raffo; Diehl, Leandro Arthur; Carleto, Lineu Domingos; Garcia, Valdinei; Carrilho, A.J.F.; Oliveira, Maria Leocádia de; Almeida, Henriqueta Galvanin Guidio de

doi:10.1590/s0004-27302005000200008

Cited by 9 publications

(5 citation statements)

References 17 publications

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“…In the same study, the prevalence of SC-Hypo was 13.5% and anti-TPO antibodies was 18.2%, but patients were younger compared to our study. In the study by Souza et al [ 12 ], evaluating 101 patients with T1DM, the prevalence of Sc-Hypo was 6.5% but FT4 was not used for diagnosis. A prevalence of 30.7% of at least one antibody was found positive in the same study, where 3 antibodies were assayed: anti-thyroglobulin, anti-microssomal, and anti-TPO.…”

Section: Discussionmentioning

confidence: 99%

“…A prevalence of 30.7% of at least one antibody was found positive in the same study, where 3 antibodies were assayed: anti-thyroglobulin, anti-microssomal, and anti-TPO. The variability of the laboratorial methods on screening of thyroid autoimmunity could influence the results described above because the latest studies use anti-TPO as preferred test [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of thyroid dysfunction in patients with diabetes mellitus

Palma

Pavesi

Nogueira

et al. 2013

Diabetol Metab Syndr

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BackgroundDiabetes mellitus (DM) and thyroid dysfunction (TD) are the two most common endocrine disorders in clinical practice. The unrecognized TD may adversely affect the metabolic control and add more risk to an already predisposing scenario for cardiovascular diseases. The objective of this study was to investigate the prevalence of TD in patients with type 1 and type 2 diabetes mellitus (T1DM and T2DM).MethodsThis is an observational cross-sectional study. Three hundred eighty-six (386) patients with T1DM or T2DM that regularly attended the outpatient clinic of the Diabetes unit, Hospital Universitário Pedro Ernesto, participated in the study. All patients underwent a clinical and laboratory evaluation. Thyroid dysfunction was classified as clinical hypothyroidism (C-Hypo) if TSH > 4.20 μUI/mL and FT4 < 0.93 ng/dL; Subclinical hypothyroidism (SC-Hypo) if TSH > 4.20 μUI/ml and FT4 ranged from 0.93 to 1.7 ng/dL; Subclinical hyperthyroidism (SC-Hyper) if TSH < 0.27 μUI/ml and FT4 in the normal range (0.93 and 1.7 ng/dL) and Clinical hyperthyroidism (C-Hyper) if TSH < 0.27 μUI/ml and FT4 > 1.7 μUI/mL. Autoimmunity were diagnosed when anti-TPO levels were greater than 34 IU/mL. The positive autoimmunity was not considered as a criterion of thyroid dysfunction.ResultsThe prevalence of TD in all diabetic patients was 14,7%. In patients who had not or denied prior TD the frequency of TD was 13%. The most frequently TD was subclinical hypothyroidism, in 13% of patients with T1DM and in 12% of patients with T2DM. The prevalence of anti-TPO antibodies was 10.8%. Forty-four (11.2%) new cases of TD were diagnosed during the clinical evaluation. The forty-nine patients with prior TD, 50% with T1DM and 76% with T2DM were with normal TSH levels.ConclusionsWe conclude that screening for thyroid disease among patients with diabetes mellitus should be routinely performed considering the prevalence of new cases diagnosed and the possible aggravation the classical risk factors such as hypertension and dyslipidemia, arising from an undiagnosed thyroid dysfunction.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prevalence of thyroid dysfunction in patients with diabetes mellitus

Palma

Pavesi

Nogueira

et al. 2013

Diabetol Metab Syndr

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“…As alterações que ocorrem na tireoide iniciamse com uma pequena infiltração da glândula por linfócitos e macrófagos, que podem gerar atrofia na glândula tireoide e destruição do tecido, levando à clássica deficiência hormonal. Em pacientes que possuem DM1, o cálculo dos anticorpos Antiperoxidase (AntiTPO) para a tireoide e Antiácido glutâmico (AntiGAD) para o pâncreas aparecem como um manejo trivial para os diagnósticos (DRIESSCHE et al,2009).…”

Section: Resultsunclassified

Proposta De Um Instrumento De Coleta De Dados Evidenciando a Relação Da Diabetes Mellitus Tipo 1 E Doença Tireoidiana Autoimune

Costa

Xavier

Silva

et al. 2022

REMS

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Introdução: O Diabetes Mellitus tipo 1 (DM1) é doença caracterizada pela insuficiência de insulina devido à perda das células β, levando à hiperglicemia. A incidência do DM1 tem sido frequentemente associada a doenças autoimunes, como as tireoidites. No entanto, tem-se observado uma maior propensão de pacientes com disfunções tireoidianas em desenvolver Doenças Tireoidianas Autoimunes (DAT) e a inexistência de consenso, na literatura, sobre os métodos de identificação da disfunção tireoidiana em pacientes com DM1. Objetivo: Objetivou-se criar instrumento de coleta de dados para avaliar a incidência, prevalência e identificar o perfil clínico de pacientes com DM1 que desenvolveram alterações na tireoide, de modo a observar a sua reprodutibilidade na obtenção de dados epidemiológicos. Metodologia: Trata-se de um estudo do tipo metodológico, estruturado em quatro etapas: criação de um instrumento de coleta de dados, validação do conteúdo, refinamento do instrumento e simulação de coleta de dados. Resultado: O primeiro instrumento de coleta de dados elaborado com base na literatura científica retornou aos pesquisadores com a recomendação de inserção das seguintes variáveis: Anti-TPO, Anti-GAD, tabagismo, etilismo, outras doenças autoimunes, gestações. Ao utilizar esse instrumento em uma simulação, percebeu-se que poderiam ser incluídos os tópicos: complicação, impacto da doença, limitações, condição socioeconômica, para se ter uma visão mais ampla do perfil do paciente e da prevalência das doenças autoimunes. Conclusão: O estudo demonstrou ser fundamental o aprimoramento das fichas de coleta de dados a fim de tornar mais preciso o rastreamento de DTA logo após o diagnóstico de DM1.

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“…Similar results were obtained in a study conducted by Souza et al study among diabetes mellitus patients and found that the prevalence of thyroid dysfunction was reported to be 14%. Majority of cases they found were of subclinical hypothyroidism which is followed by clinical hypothyroidism (14).…”

Section: Discussionmentioning

confidence: 99%

Assessment of Thyroid Function Among Diabetes Mellitus Patients

Nayak

2019

IJMBS

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Background: Thyroid disorders are reported in higher magnitude among general population, although its prevalence is not as high as prevalence of diabetes mellitus. Thyroid disorders are endocrine in nature as diabetes mellitus and various studies were conducted to find out correlation between both the disorders. Material & Methods: Patients who were presenting with type 2 diabetes mellitus and confirmed with laboratory investigations and healthy controls were enrolled from outdoor and from ward by simple random sampling. Clearance from Institutional Ethics Committee was taken before start of study. Written informed consent was taken from each study participant Conclusion: We concluded from the present study that the patients of diabetes mellites had higher prevalence of thyroid dysfunction in comparison to the healthy controls enrolled in the study. We found subclinical hypothyroidism was more common than clinical hypothyroidism.

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Prevalência de auto-imunidade tireoidiana em um grupo de pacientes com diabetes mellitus tipo 1 em Londrina, PR

Cited by 9 publications

References 17 publications

Prevalence of thyroid dysfunction in patients with diabetes mellitus

Prevalence of thyroid dysfunction in patients with diabetes mellitus

Proposta De Um Instrumento De Coleta De Dados Evidenciando a Relação Da Diabetes Mellitus Tipo 1 E Doença Tireoidiana Autoimune

Assessment of Thyroid Function Among Diabetes Mellitus Patients

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