Insulina: efeitos cardiovasculares e aplicações terapêuticas

Schaan, Beatriz D’Agord; Rabelo, Eneida Rejane; Irigoyen, Maria Cláudia

doi:10.1590/s0004-27302004000600004

Cited by 2 publications

(2 citation statements)

References 51 publications

(60 reference statements)

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“…Classicamente são conhecidos os efeitos da insulina sobre o metabolismo dos substratos, mas este hormônio também tem efeitos sobre a função nervosa, hemostasia, metabolismo das lipoproteínas e função vascular (29). A insulina também estimula a síntese de lipídios nos vasos sangüíneos, em particular a síntese do colesterol e do LDLc, que se ligam às células do músculo liso arterial e aos monócitos/macrófagos (35).…”

Section: Hiperglicemia E Hiperinsulinemiaunclassified

O papel da lipemia pós-prandial na gênese da aterosclerose: particularidades do diabetes mellitus

Signori

Plentz

Irigoyen

et al. 2007

Arq Bras Endocrinol Metab

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Atherosclerosis is a complex and multifactorial disease, which determines clinical events that cause significant morbidity-mortality, represented by acute myocardial infarction, angina and sudden death. It is associated with lipid disturbances, platelet activation, thrombosis, endothelial dysfunction, inflammation, oxidative stress, altered matrix metabolism, among other disturbances. All these abnormalities are usual and more pronounced in diabetic patients, as well as in the post-prandial state. Among the coronary artery disease risk factors that are not usually employed in clinical practice in the whole population, postprandial hyperlipemia plays a major role, being a possible early marker of metabolic abnormalities and vascular dysfunction not yet seen in the fasting state. Recent results showed that post-oral lipid overload changes are negatively associated with endothelial dysfunction, and vascular reactivity abnormalities are strongly related to atherosclerosis progression and cardiovascular events. These abnormalities could disclose a lipid intolerance state that can be detected in apparently healthy subjects even before fasting abnormalities are seen. This review will deal with the pathophysiology changes involved in post-prandial hyperlipemia and its relationship with atherogenesis, with particular emphasis to diabetes mellitus.

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Section: Hiperglicemia E Hiperinsulinemiaunclassified

O papel da lipemia pós-prandial na gênese da aterosclerose: particularidades do diabetes mellitus

Signori

Plentz

Irigoyen

et al. 2007

Arq Bras Endocrinol Metab

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“…By-products of FFA are oxidized through β-oxidation to produce ATP to maintain contractile viability. A critical point is when myocardial ischemia leads to a series of metabolic changes in the cardiomyocytes, such as blockage of fatty acid oxidation, increased anaerobic glycolysis, and lactic acid accumulation 12 . Hence, this metabolic disorder may lead to functional deficits in the myocardial mitochondrial, which contribute to cardiac hypertrophy 7 .…”

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confidence: 99%

Effects of myocardial infarction and an intensive exercise bout on kinetic of lactate, and LDH-B levels in spontaneously hypertensive rats

Marschner

Martins

Markoski

et al. 2020

Motriz: rev. educ. fis.

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This study aimed to evaluate the kinetics of lactate and lactate dehydrogenase B (LDH-B) protein levels as well as the maximum effort capacity of spontaneously hypertensive rats (SHRs) with experimental acute myocardial infarction (AMI). Methods: thirty-two SHRs were divided into (n=8/group): S (sham), SE (sham+exercise), I (AMI), and IE (AMI+exercise). A maximum exercise test (treadmill) was evaluated before AMI or sham surgery. Echocardiography was performed 48h after the surgery. Lactacidemia was assessed at rest and during an intense exercise bout (48h after echocardiography). A two-way ANOVA followed by the post-hoc (Bonferroni) test was used, p<0.05. Results: In the end, the heart was removed for analysis of LDH-B. AMI resulted in lower cardiac output (S vs I: ∆51.3%, p<0.001), ejection fraction (S vs I: ∆60.5%, p<0.001) and shortening fraction (S vs I: ∆72.4%, p<0.001). The IE showed a reduction in exercise capacity when compared with pre-AMI values (1.50±0.1 vs 1.38±0.2 km/h; p=0.030) but not when compared with SE (1.41±0.3 vs 1.38±0.2 km/h; p=0.208). During the exhaustion exercise session, IE group showed lower lactacidemia at 12 min (∆9.7%, p=0.042) and 18 min (∆8.3%, p=0.038). No differences were observed in the protein level of LDH-B among the groups (p=0.573). However, when the AMI factor was considered alone, LDH-B expression was lower (sham vs AMI rats, p=0.040). Conclusion: LDH-B protein levels in cardiac tissue appear to be associated with AMI only. Furthermore, AMI induced a reduction in exercise capacity but did not affect lactacidemia during the intense exercise bout.

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Insulina: efeitos cardiovasculares e aplicações terapêuticas

Cited by 2 publications

References 51 publications

O papel da lipemia pós-prandial na gênese da aterosclerose: particularidades do diabetes mellitus

O papel da lipemia pós-prandial na gênese da aterosclerose: particularidades do diabetes mellitus

Effects of myocardial infarction and an intensive exercise bout on kinetic of lactate, and LDH-B levels in spontaneously hypertensive rats

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