2004
DOI: 10.1590/s0004-27302004000200008
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Marcadores de inflamação em pacientes com Diabetes Mellitus tipo 1

Abstract: To evaluate markers of inflammation, we studied 48 patients with type 1 diabetes [DM1, 23F:25M, 19.9+/-9.8 years and duration of DM of 5 (1-21) years& and 66 non-DM subjects, matched for sex, age, and stages of puberty according to Tanner. C-reactive protein (CRP), alpha1-acid glycoprotein (AGP) and fibrinogen were measured by turbidimetric immunoassay and urinary albumin excretion rate (AER) was determined in timed overnight urine samples by RIA. Microalbuminuria was defined when two out of three urine sample… Show more

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Cited by 6 publications
(3 citation statements)
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“…However, recent studies have considered AGP to be an effective marker of systemic inflammation, strongly associated with cytokines and a better diagnostic marker than hs-CRP because, although hs-CRP has a faster response (1 to 2 days), AGP levels remain elevated for longer periods (5 to 6 days) (Ayoya et al 2010;Fournier et al 2000). Furthermore, AGP has been used as a diagnostic marker of systemic inflammation in cardiometabolic diseases (Piccirillo et al 2004;Toscano et al 2014).…”
Section: Discussionmentioning
confidence: 99%
“…However, recent studies have considered AGP to be an effective marker of systemic inflammation, strongly associated with cytokines and a better diagnostic marker than hs-CRP because, although hs-CRP has a faster response (1 to 2 days), AGP levels remain elevated for longer periods (5 to 6 days) (Ayoya et al 2010;Fournier et al 2000). Furthermore, AGP has been used as a diagnostic marker of systemic inflammation in cardiometabolic diseases (Piccirillo et al 2004;Toscano et al 2014).…”
Section: Discussionmentioning
confidence: 99%
“…Entre as condições de saúde ou doenças que foram alvo das pesquisas selecionadas nessa revisão, destacam-se a Pré-eclâmpsia 31 , Diabetes Mellitus Tipo 1 32 , doença obstrutiva de artérias carótidas 33 , Infl amação de baixo grau em crianças e adolescentes 34 , Diabetes mellitus tipo 2 (DM2) e hipertensão arterial sistêmica 50 , Hipertensão e Obesidade Central 36 , Obesidade 37 , Disfunção erétil 38 , Obesidade e cirurgia bariátrica 39 , Doença arterial coronariana 40 , pré-hipertensão 41 , artrite reumatoide 42 , diabetes e cirurgia bariátrica 44 , Obesidade e cirurgia bariátrica 45 , insufi ciência cardíaca 46 , Obesidade e cirurgia bariátrica 47 .…”
Section: Discussionunclassified
“…Em relação ao Diabetes mellitus Tipo 1, há relatos de níveis elevados das proteínas de fase aguda, como a proteína C reativa, entre outras. Também se considera que a persistência de níveis elevados de PCR representariam um estado de infl amação crônica leve que possivelmente é um dos responsáveis pela aterosclerose acelerada entre essa população 32 .…”
Section: Discussionunclassified