Abstract:RESUMOA hiperinsulinemia parece contribuir para o hiperandrogenismo por reduzir os níveis séricos tanto da SHBG quanto da IGFBP-1. Avaliamos os níveis de SHBG e IGFBP-1 e sua correlação com androgênios e insulina em 44 meninas selecionadas com pubarca precoce (PP) e 18 controles (C) pré-puberais (7,3±1,3 x 6,8±1,6 anos). Foram avaliados: o índice de massa corporal (IMC), a idade óssea (IO) e os níveis séricos de SHBG, IGFBP-1, insulina (I), glicose (G), testosterona (T), androstenediona (A), SDHEA e cortisol (… Show more
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