Função gonadal de sobreviventes de doença de Hodgkin tratados na infância e adolescência com quimioterapia

Abstract

We studied the gonadal function in 21 male patients with Hodgkin's disease (group A), who had received chemotherapy during childhood and adolescent, and compared them to 20 healthy young men (group B). The median age at the time of the study was 18 years (17-23), and at the time of chemotherapy, 10 years (6-19). At that time, 14 were prepubertal and 7 pubertal; by the time of the study all were Tanner V, and had completed chemotherapy 3 to 11 years previously. The median testicular volume was significantly higher in patients than controls (p= 0.001). No significant differences were found in TT, SHBG, PRL and LH concentrations between patients and controls. The median serum FSH concentration was significantly higher in patients than controls (p= 0.0001). We detected an appreciable difference in peak FSH and LH levels after a GnRH test

Cytoprotective effects of L-carnitine on testicular biometry and stereology of albino rats treated with vincristine sulfate in the prepubertal phase

“…The reduction in testicular weight, as well as the other biometric variables studied, has a dose-dependent relationship in most chemotherapy drugs, the reductions observed in this research are in agreement with other studies (Okada et al,2009;Vendramini et al, 2010). Furthermore, the decrease in testicular weight is considered an important indication of loss of seminiferous epithelial cells (Bordallo et al, 2001;Hacker-Klom et al, 1986;Howell & Shalet, 2001), although changes in the interstitium should also be considered.…”

Efeitos de sulfato de vincristine sobre os testículos de ratos albinos, tratados na fase pré-púbere

“…A redução do peso corpóreo, peso testicular assim como das demais variáveis estudadas possui relação dose dependente na maioria das drogas, ademais, o peso testicular é considerado uma variável importante na avaliação dos níveis de perda celular do epitélio seminífero (Hacker-Klom et al 1986, Bordallo et al 2001, Howell & Shalet 2001. Todos os grupos experimentais apresentaram reduções muito significativas (p≤0,01) dos pesos testiculares absolutos e relativos quando comparado a seus referentes controles.…”