2000
DOI: 10.1590/s0004-27302000000500009
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Abstract: Recebido em 22/11/99 Revisado em 22/03/00Aceito em 12/05/00 RESUMOAs doenças auto-imunes da tireóide são o resultado da quebra da autotolerância causada principalmente por fatores genéticos e ambientais. O retrovírus HTLV-1 tem sido implicado como um importante fator ambiental desencadeador destas doenças. Objetivando encontrar evidên-cias da participação deste retrovírus, 47 tecidos tireoideanos parafinados de 45 pacientes com doença de Graves e dois com tireoidite de Hashimoto, juntamente com tecidos tireoid… Show more

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(1 citation statement)
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“…47 Filho et al, studying thyroid tissue from cadavers with GD and HT and normal controls, found 83% and 85% positivity for p19(gag) and gp21(env) HTLV-1 proteins, respectively, without any clinical evidence of HTLV-1 infection. 48 These fi ndings did not confi rm the role of HTLV-1 in the pathogenesis of thyroid autoimmunity, but suggest that they can be the result of cross reaction, molecular mimicry or endogenous retrovirosis.…”
Section: Autoimmune Thyroid Diseasesmentioning
confidence: 84%
“…47 Filho et al, studying thyroid tissue from cadavers with GD and HT and normal controls, found 83% and 85% positivity for p19(gag) and gp21(env) HTLV-1 proteins, respectively, without any clinical evidence of HTLV-1 infection. 48 These fi ndings did not confi rm the role of HTLV-1 in the pathogenesis of thyroid autoimmunity, but suggest that they can be the result of cross reaction, molecular mimicry or endogenous retrovirosis.…”
Section: Autoimmune Thyroid Diseasesmentioning
confidence: 84%