Ultra-sonografia pélvica em 140 meninas normais pré e pós-puberais

Teixeira, Rosimere J.; Silva, Valéria C.G.; Freitas, Josele R.; Henriques, Jodélia L.S.; Guimarães, Marília M.

doi:10.1590/s0004-27301999000300008

Cited by 4 publications

(5 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We adopted this classification after a study of 140 healthy girls aged 2-18 years 23 . The equipment used was that of high resolution in real time: LOGIC 500 GE with a 3.5 MHz probe, and a Hitachi model EUB 305, with 3.5 and 5.0 MHz transducers.…”

Section: Methodsmentioning

confidence: 99%

The Relationship Between Ovarian Structure and Serum Insulin, Insulin-like Growth Factor I (IGF-I) and its Binding Protein (IGFBP-1 and IGFBP-3) Levels in Premature Pubarche

Teixeira¹,

Silva²,

Gazolla³

et al. 2002

Journal of Pediatric Endocrinology and Metabolism

View full text Add to dashboard Cite

The aim of this study was to determine serum insulin, insulin-like growth factor-I (IGF-I) and its binding proteins (IGFBP-1 and IGFBP-3) levels and their relationship with androgen levels and ovarian structure in 23 girls with premature pubarche (PP). Fasting levels of testosterone, dehydroepiandrosterone (DHEA) and its sulfate (DHEAS), androstenedione (delta4A), sex hormone binding globulin (SHBG), glucose (G), insulin (I), IGF-I, IGFBP-1, IGFBP-3 were measured. Androgens or steroid hormone levels > 3 SD of normal postpubertal levels were considered as an exaggerated response to the ACTH test. The fasting I to G ratio (FIGR) was calculated and FIGR > 22 was suggestive of insulin resistance (IR). A pelvic ultrasound (US) was carried out and the ovarian structure was divided into five classes (c): c1--homogeneous, c2--microcystic, c3--multicystic, c4--polycystic and c5--follicular. The girls with PP were divided into two groups according to the main ovarian classes observed: PPc1 (n = 6) and PPc2 (n = 15). The FIGR showed IR in 44% of patients. The androgens, SHBG, G, I, FIGR, IGF-I and IGFBP-1 levels were similar among the groups (PPc1 vs PPc2). An exaggerated response to ACTH was more common and IGFBP-3 levels were higher in the PPc2 than in the PPc1 group (p = 0.04). Regression analysis revealed that I was correlated with DHEAS (r = -0.43, p = 0.04) and IGFBP-1 (r = -0.51, p = 0.01); IGF-I was correlated with DHEA (r = -0.42, p = 0.05), delta4A (r = -0.47, p = 0.02), SHBG (r = -0.43, p = 0.04), IGFBP-1 (r = -0.61, p = 0.002) and IGFBP-3 (r = 0.56, p = 0.005); IGFBP-1 was correlated with SHBG (r = 0.56, p = 0.005). These findings suggest that there might be interactions between the insulin-IGF-I-IGFBPs system and hyperandrogenism. However, the possible causal role of adrenal androgen hypersecretion on the insulin-IGF-I-IGFBPs axis and ovarian structure in girls with PP remains to be established. Since studies reveal that IGFBP-3 levels could be a negative predictor for insulin sensitivity throughout puberty, we hypothesize that girls with PP and microcystic ovaries are at risk of developing IR in the course of normal puberty.

show abstract

Section: Methodsmentioning

confidence: 99%

The Relationship Between Ovarian Structure and Serum Insulin, Insulin-like Growth Factor I (IGF-I) and its Binding Protein (IGFBP-1 and IGFBP-3) Levels in Premature Pubarche

Teixeira¹,

Silva²,

Gazolla³

et al. 2002

Journal of Pediatric Endocrinology and Metabolism

View full text Add to dashboard Cite

show abstract

“…Com o início da puberdade, os ovários homogêneos não são mais visibilizados e ocorre uma mudança na estrutura, com predomínio dos microcistos e multicistos. Os folículos dominantes ou préovulatórios são observados principalmente próximo à menarca, quando a maturação sexual é mais avançada (12) . Os multicistos parecem ocorrer como uma resposta normal da maturação ovariana, antes da seleção do folículo dominante, e o diâmetro máximo dos folículos au- I I II II II III IV IV IV…”

Section: Discussionunclassified

Ovários policísticos em meninas e adolescentes normais: uma avaliação ultra-sonográfica

et al. 2001

Self Cite

View full text Add to dashboard Cite

Realizamos ultra-sonografia pélvica em tempo real e de alta resolução em 140 meninas com idade entre dois e 18 anos, para descrever a prevalência de ovários policísticos durante o desenvolvimento puberal normal. O volume dos ovários foi calculado e sua estrutura classificada como homogênea, microcística, multicística, policística e folicular. O volume aumentou e a freqüência das classes ovarianas variou de acordo com o status puberal. Os ovários eram de aspecto policístico em 8% (duas meninas pré-puberais e nove pós-puberais), com volume normal em 8/11 pacientes. Consideramos que a utilização do volume como critério diagnóstico de ovários policísticos pode ser de difícil interpretação durante este período e enfatizamos a importância da avaliação da ecogenicidade do estroma pelo ultra-som. Uma hipótese atrativa, mas que necessita de confirmação através de estudos longitudinais, é se essas meninas com ovários policísticos na ultra-sonografia serão destinadas, em alguns casos, a tornar-se adultas com a síndrome dos ovários policísticos.

show abstract

“…All participants were assessed with regard to stature, weight, pubic hair development according to Tanner criteria, body mass index (BMI) and BA. We adopted this classification after a study of 140 healthy girls aged 2-18 years 13 . using the conventional method of a full bladder, obtained after the oral administration of fluids and voluntary urinary retention.…”

Section: Methodsmentioning

confidence: 99%

The Relationship Between Ovarian Structure and Hyperandrogenism in Premature Pubarche

Teixeira¹,

Silva²,

Freitas³

et al. 2001

Journal of Pediatric Endocrinology and Metabolism

View full text Add to dashboard Cite

The aim of this study was to describe the ovarian structure (OS) and its relationship with hyperandrogenism in girls with premature pubarche (PP). A pelvic ultrasound was carried out in 23 girls with PP and in 57 prepubertal age-matched controls (C), and the OS was subdivided into five classes (c): 1-homogeneous; 2-microcystic, 3-multicystic, 4-polycystic and 5-follicular. In the girls with PP, an ACTH test was performed, and the presence of hormonal levels >3 SD of postpubertal normal levels and not compatible with late-onset congenital adrenal hyperplasia were considered an exaggerated response. The fasting levels of glucose (G) and insulin (I) were measured and the fasting I to G ratio (FIGR) was calculated. FIGR >22 was suggestive of I resistance (IR). The microcystic structure (c2) was more frequently found in the PP than in the C group (63% vs 35%, p=0.03). In the PP group, we observed the following OS: cl (n=6), c2 (n=15), c3 (n=1) and c4 (n=1). 11-Deoxycortisol--both basal and after ACTH--was greater in the PPc2 group than in PPc1 (p=0.04, p=0.0008, respectively). We also observed an exaggerated response to ACTH in 87% of the girls with PP, greater in the PPc2 group than in PPc1 (p=0.04). The FIGR showed IR in 44% of girls with PP, but I levels and FIGR were similar between PPc1 and PPc2. These findings suggest generalized adrenocortical hyperresponsiveness in girls with PP, which is more accentuated in PPc2. Long-term follow-up of girls with PP into adulthood is warranted to ascertain whether microcystic ovarian structure precedes functional ovarian hyperandrogenism.

show abstract

Ultra-sonografia pélvica em 140 meninas normais pré e pós-puberais

Cited by 4 publications

References 19 publications

The Relationship Between Ovarian Structure and Serum Insulin, Insulin-like Growth Factor I (IGF-I) and its Binding Protein (IGFBP-1 and IGFBP-3) Levels in Premature Pubarche

The Relationship Between Ovarian Structure and Serum Insulin, Insulin-like Growth Factor I (IGF-I) and its Binding Protein (IGFBP-1 and IGFBP-3) Levels in Premature Pubarche

Ovários policísticos em meninas e adolescentes normais: uma avaliação ultra-sonográfica

The Relationship Between Ovarian Structure and Hyperandrogenism in Premature Pubarche

Contact Info

Product

Resources

About