Acetone extract from Streptoverticillium sp., a bacterium isolated from Brazilian Cerrado soil, induces anti-inflammatory activity in mice

Cruz, Rodrigo Bonfim; Galdino, Pablinny Moreira; Penna, Karlla G.B.D.; Hoffmann, Karen; Costa, Élson Alves; Bataus, Luiz Artur Mendes

doi:10.1590/s0001-37652013000200009

Cited by 2 publications

(2 citation statements)

References 11 publications

(2 reference statements)

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“…have an anti-inflammatory effect (Da Cruz et al 2013). Recently, new data was published about the importance of TGases in chronic inflammatory diseases, in wound healing, in repair of tissues and development of fibrosis and autoimmune reactions, in chronic degenerative diseases (arthritis, atherosclerosis, and neurodegenerative states), and in oncologic pathology (Shleikin and Danilov 2011).…”

Section: Microbial Transglutaminasementioning

confidence: 99%

Transglutaminases: recent achievements and new sources

Martins

Matos

Costa

et al. 2014

Appl Microbiol Biotechnol

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Transglutaminases are a family of enzymes (EC 2.3.2.13), widely distributed in various organs, tissues, and body fluids, that catalyze the formation of a covalent bond between a free amine group and the γ-carboxamide group of protein or peptide-bound glutamine. Besides forming these bonds, that exhibit high resistance to proteolytic degradation, transglutaminases also form extensively cross-linked, generally insoluble, protein biopolymers that are indispensable for the organism to create barriers and stable structures. The extremely high cost of transglutaminase of animal origin has hampered its wider application and has initiated efforts to find an enzyme of microbial origin. Since the early 1990s, many microbial transglutaminase-producing strains have been found, and production processes have been optimized. This has resulted in a rapidly increasing number of applications of transglutaminase in the food sector. However, applications of microbial transglutaminase in other sectors have also been explored, but in a much lesser extent. Our group has identified a transglutaminase in the oomycete Phytophthora cinnamomi, which is able to induct defense responses and disease-like symptoms. In this mini-review, we report the achievements in this area in order to illustrate the importance and the versatility of transglutaminases.

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Section: Microbial Transglutaminasementioning

confidence: 99%

Transglutaminases: recent achievements and new sources

Martins

Matos

Costa

et al. 2014

Appl Microbiol Biotechnol

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“…Inflammation is a defensive response of the body to pathogenic agents, which is a common and important basic pathological process in the development of diseases (7,8). An appropriate inflammatory response is beneficial for the body to eliminate the invading pathogens, but an exaggerated inflammatory response, such as that to lung edema, peritonitis and sepsis, is harmful for the body (9).…”

Section: Introductionmentioning

confidence: 99%

Anti-exudation effects of sodium ferulate and oxymatrine combination via modulation of aquaporin 1

Sun

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. The present study aimed to investigate the anti-exudative effects of sodium ferulate combined with oxymatrine in a mouse model of acetic acid-induced peritonitis. Furthermore, the underlying mechanisms were explored by determining the effects of these drugs on the volume and aquaporin 1 (AQP1) expression in vascular endothelial cells on omentum majus and human umbilical vein endothelial cells (HUVEC). Treatment with sodium ferulate combined with oxymatrine was shown to significantly inhibit acetic acid-induced vascular permeability in the peritonitis model mice and furthermore to significantly decrease the optical density of Evans blue, the leukocyte number and the levels of interleukin-6, C-reactive protein and interferon-γ in peritoneal lavage fluid. Pathological analysis of the omentum majus revealed that sodium ferulate and oxymatrine combination treatment significantly alleviated vascular endothelial cell edema and capillary loss. In vitro, flow cytometry revealed that the volume of HUVECs was significantly reduced in the drug treatment groups, as reflected in the forward scatter value. The optical density of AQP1 on the membrane of the vascular endothelial cells on omentum majus and HUVECs were significantly increased in the drug treatment groups compared with the model group. These results indicated that sodium ferulate and oxymatrine combination treatment possessed prominent anti-exudative effects and that the underlying mechanisms are likely to include the improvement of vascular endothelial cellular edema, possibly by upregulation of AQP1 expression on their membrane, which requires further exploration.

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Acetone extract from Streptoverticillium sp., a bacterium isolated from Brazilian Cerrado soil, induces anti-inflammatory activity in mice

Cited by 2 publications

References 11 publications

Transglutaminases: recent achievements and new sources

Transglutaminases: recent achievements and new sources

Anti-exudation effects of sodium ferulate and oxymatrine combination via modulation of aquaporin 1

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