Role of the medulla oblongata in normal and high arterial blood pressure regulation: the contribution of Escola Paulista de Medicina - UNIFESP

Cravo, Sérgio L.; Campos, Rui; Colombari, Eduardo; Sato, Mônica Akemi; Bergamaschi, Cássia T.; Pedrino, Gustavo Rodrigues; Ferreira-Neto, Marcos L.; Lopes, Oswaldo Ubrı́aco

doi:10.1590/s0001-37652009000300021

Cited by 10 publications

(12 citation statements)

References 84 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although the blockade of glutamate receptors in the RVLM does not affect the resting blood pressure in the normal state (Sved et al 2002), in the hypertensive state, such as the renovascular model, the glutamatergic input to the RVLM is increased, and its blockade reduces blood pressure (Bergamaschi et al 1995), thereby contributing to the increase in rSNA (Cravo et al 2009). The RVLM receives input from the PVN, which is another region involved in the regulation of renal function.…”

Section: Efferent Signals From the Cns To The Kidneymentioning

confidence: 99%

See 1 more Smart Citation

The crosstalk between the kidney and the central nervous system: the role of renal nerves in blood pressure regulation

Nishi

Bergamaschi

Campos

2015

Experimental Physiology

Self Cite

View full text Add to dashboard Cite

New Findings r What is the topic of this review?This review describes the role of renal nerves as the key carrier of signals from the kidneys to the CNS and vice versa; the brain and kidneys communicate through this carrier to maintain homeostasis in the body. r What advances does it highlight?Whether renal or autonomic dysfunction is the predominant contributor to systemic hypertension is still debated. In this review, we focus on the role of the renal nerves in a model of renovascular hypertension.The sympathetic nervous system influences the renal regulation of arterial pressure and body fluid composition. Anatomical and physiological evidence has shown that sympathetic nerves mediate changes in urinary sodium and water excretion by regulating the renal tubular water and sodium reabsorption throughout the nephron, changes in the renal blood flow and the glomerular filtration rate by regulating the constriction of renal vasculature, and changes in the activity of the renin-angiotensin system by regulating the renin release from juxtaglomerular cells. Additionally, renal sensory afferent fibres project to the autonomic central nuclei that regulate blood pressure. Hence, renal nerves play a key role in the crosstalk between the kidneys and the CNS to maintain homeostasis in the body. Therefore, the increased sympathetic nerve activity to the kidney and the renal afferent nerve activity to the CNS may contribute to the outcome of diseases, such as hypertension.

show abstract

Section: Efferent Signals From the Cns To The Kidneymentioning

confidence: 99%

“…), thereby contributing to the increase in rSNA (Cravo et al . ). The RVLM receives input from the PVN, which is another region involved in the regulation of renal function.…”

Section: Introductionmentioning

confidence: 97%

The crosstalk between the kidney and the central nervous system: the role of renal nerves in blood pressure regulation

Nishi

Bergamaschi

Campos

2015

Experimental Physiology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Angiotensin II inhibits baroreceptor function (Huang & Leenen, 1998;Huang et al, 2006;Xie et al, 2006;Parsons & Coffman, 2007;Carlson & Wyss, 2008;Cravo et al, 2009). …”

Section: Baroreceptorsmentioning

confidence: 99%

Effect of Tulbaghia violacea on the blood pressure and heart rate in male spontaneously hypertensive Wistar rats

Raji

Mugabo

Obikeze

2012

Journal of Ethnopharmacology

View full text Add to dashboard Cite

Effect of Tulbaghia violacea on the blood pressure and heart rate in male spontaneously hypertensive Wistar rats I. A. RAJITulbaghia violacea Harv. (Alliaceae) is a small bulbous herb which belongs to the family, Alliaceae, most commonly associated with onions and garlic. In South Africa (SA), this herb has been traditionally used in the treatment of various ailments, including fever, colds, asthma, paralysis, hypertension (HTN) and stomach problems. The aim of this study was to evaluate the effect of methanol leaf extracts (MLE) of T. violacea on the blood pressure (BP) and heart rate (HR) in anaesthetized male spontaneously hypertensive rats; and to find out the mechanism(s) by which it acts.The MLE of T. violacea (5 -150 mg/kg), angiotensin I (ang I, 3.1 -100 µg/kg), captopril (10 mg/kg), angiotensin II (ang II, 3.1 -50 µg/kg), losartan (30 mg/kg), phenylephrine T. violacea (60 mg/kg) and captopril (10 mg/kg) were injected intraperitoneally into iii some SHR for 21 days to investigate the chronic effect of these agents on plasma levels of aldosterone. The mean change, the mean of the individual percentage changes and the percentage difference (in mean) observed with each intervention was calculated and statistically analyzed using the Student's t test for significant difference (p < 0.05). The Microsoft Excel software was used for statistical analysis.T. violacea significantly (p < 0.05) reduced the systolic, diastolic, and mean arterial BP;and HR dose-dependently. In a dose-dependent manner, ang I, ang II, phenylephrine significantly (p < 0.05) increased the BP, while propranolol, muscarine and atropine reduced the BP. The increases in BP due to dobutamine were not dose-dependent. In a dose dependent manner, phenylephrine and propranolol reduced the HR, while dobutamine increased the HR. The effect of ang I, ang II, muscarine and atropine on HR were not dose-dependent; with both increases as well as decreases observed with ang I, and II and atropine, while decreases were seen with muscarine. Captopril produced significant (p < 0.05) reduction in BP which were not associated with any change in HR.The co-infusion of ang I with the MLE produced significant (p < 0.05) reduction in BP, which were not associated with significant changes in HR. The co-infusion of ang II with the MLE did not produce any significant changes in BP or HR when compared to the infusion of the standard drug alone. The co-infusion of phenylephrine with the MLE did

show abstract

“…It is essential to the body′s stability and function: deviations being associated with cognitive impairment, migraine, dementia, stroke, diabetes mellitus, cardiovascular disorders, depression, sleep apnoea, etc. Within the medulla oblongata[4041] networks of neurons respond to signals received from baroreceptors and the autonomic nervous system[5253], and regulate blood pressure[5455]. They do so by changing heart rate or by contracting (or expanding) specific blood vessels in order to adjust the flow of blood.…”

Section: Regulation Of Blood Pressurementioning

confidence: 99%

Mathematical modeling the neuroregulation of blood pressure using a cognitive top-down approach

Ewing¹

2010

NAJMS

View full text Add to dashboard Cite

Background:The body′s physiological stability is maintained by the influence of the autonomic nervous system upon the dynamic interaction of multiple systems. These physiological systems, their nature and structure, and the factors which influence their function have been poorly defined. A greater understanding of such physiological systems leads to an understanding of the synchronised function of organs in each neural network i.e. there is a fundamental relationship involving sensory input and/or sense perception, neural function and neural networks, and cellular and molecular biology. Such an approach compares with the bottom-up systems biology approach in which there may be an almost infinite degree of biochemical complexity to be taken into account.Aims:The purpose of this article is to discuss a novel cognitive, top-down, mathematical model of the physiological systems, in particular its application to the neuroregulation of blood pressure.Results:This article highlights the influence of sensori-visual input upon the function of the autonomic nervous system and the coherent function of the various organ networks i.e. the relationship which exists between visual perception and pathology.Conclusions:The application of Grakov′s model may lead to a greater understanding of the fundamental role played by light e.g. regulating acidity, levels of Magnesium, activation of enzymes, and the various factors which contribute to the regulation of blood pressure. It indicates that the body′s regulation of blood pressure does not reside in any one neural or visceral component but instead is a measure of the brain′s best efforts to maintain its physiological stability.

show abstract

Role of the medulla oblongata in normal and high arterial blood pressure regulation: the contribution of Escola Paulista de Medicina - UNIFESP

Cited by 10 publications

References 84 publications

The crosstalk between the kidney and the central nervous system: the role of renal nerves in blood pressure regulation

The crosstalk between the kidney and the central nervous system: the role of renal nerves in blood pressure regulation

Effect of Tulbaghia violacea on the blood pressure and heart rate in male spontaneously hypertensive Wistar rats

Mathematical modeling the neuroregulation of blood pressure using a cognitive top-down approach

Contact Info

Product

Resources

About