Modulatory effects of rutin on biochemical and hematological parameters in hypercholesterolemic Golden Syrian hamsters

Abstract

Flavonoids have been reported to exhibit several pharmacological properties, mainly in cardiovascular and inflammatory diseases. In the present study, we observed that rutin, a known glycosylated flavonoid isolated from Dimorphandra mollis, had a lowering effect on plasma triglyceride levels of diet-induced hypercholesterolemic Golden Syrian hamsters, but did not change total cholesterol and high-density lipoprotein cholesterol levels. Moreover, high-fat or rutinsupplemented diets showed no immunotoxic effects, since no significant changes were observed on total white blood cells, granulocytes and mononuclear cells, as well as on the neutrophil apoptosis degree, when compared to untreated animals. Therefore, rutin seems to be a selective and non-toxic modulator of hypercholesterolemia, which can be promising for the development of new drugs.

Ocimum gratissmum aqueous extract reduces plasma lipid in hypercholesterol-fed hamsters

“…Past studies have indicated that catechins can reduce total cholesterol and LDL, but no significant impact of high-density lipoprotein cholesterol 45; caffeic acid can inhibit fatty acid synthase, 3-hydroxy-3-methylglutaryl CoA reductase and acyl-CoA:cholesterol acyltransferase activities, while they increased fatty acid beta-oxidation activity and peroxisome proliferator-activated receptors alpha expression in the liver compared to the high-fat group 46; epicatechin may be an antiaging compound, as evidenced by the improved db/db mouse survival and the favorable changes in a variety of age-related biomarkers, including the development of obesity and hyperglycemia 47 and rutin promoted the excretion of fecal sterols, thereby decreasing absorption of dietary cholesterol and lowering the plasma triglyceride levels of diet-induced hypercholesterolemia 48. Thus, according to these characteristics and comparing to results of the rosuvastatin effects, we suggested that OGE lowering hypercholesterolemia may be mediated through multiple reasons.…”

Effect of Rutin in Buckwheat Noodle on Lipid Metabolism in Rats

“…However, the suppression of body and adipose tissue weight gain by dietary rutin described in these reports was not observed in the present investigation. Rutin was also reported to suppress plasma triglyceride level but not total and HDL cholesterol levels in Golden Syrian hamsters fed a high-cholesterol diet (Kanashiro et al, 2009). Odbayar et al (2006) reported that dietary quercetin but not rutin reduced serum cholesterol and phospholipid levels in ICR mice, and that quercetin inhibited the expression of various kinds of mRNA related to fatty acid synthesis.…”

“…Moreover, He et al (1995) indicated that buckwheat intake was associated with lower serum total and LDL cholesterol levels in their epidemiologic study. Although the above mentioned reports about the biological activity of buckwheat did not clarify the role of rutin or quercetin in these effects, some investigators suggested that dietary rutin or quercetin affected lipid metabolism in animal experiments (Panchal et al, 2011;Hsu et al, 2009;Choi et al, 2006;Kanashiro et al, 2009). However, it remains to be clarified whether dietary rutin or quercetin in buckwheat ameliorates lipid metabolism, since starch and protein in buckwheat flour were also suggested to have beneficial effects on lipid metabolism (Skrabanja et al, 2001;Kayashita et al, 1997).…”

The effect of meniran herbs extract (Phyllantus niruri) to triglycerides blood level in wistar rats

“…Herba meniran diekstraksi dengan menggunakan pelarut etanol, sehingga dihasilkan ekstrak herba meniran yang di dalamnya terdapat rutin dan lupeol. Senyawa-senyawa tersebut diketahui dapat berfungsi menurunkan kadar trigliserida dalam tubuh (Itoh et al 2009;Kanashiro et al 2009;Park et al 2002;Pulok 2001;Sudhahar et al 2006). Selain itu dari segi ekonomis, herba meniran cukup murah dan mudah untuk mendapatkan tanaman tersebut.…”