volume 78, issue 4, P645-665 2006
DOI: 10.1590/s0001-37652006000400004
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Abstract: ABSTRACTMajor modifi cations of immune system have been observed in African trypanosomiasis. These immune reactions do not lead to protection and are also involved in immunopathology disorders. The major surface component (variable surface glycoprotein,VSG) is associated with escape to immune reactions, cytokine network dysfunctions and autoantibody production. Most of our knowledge result from experimental trypanosomiasis. Innate resistance elements have been characterised. In infected mice, VSG preferential…

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