Voltammetric characteristics of miconazole and its cathodic stripping voltammetric determination

Pereira, Francisco Claudece; Stradiotto, Nelson Ramos; Zanoni, María Valnice Boldrin

doi:10.1590/s0001-37652002000300005

Cited by 7 publications

(4 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The voltammetric experiments were performed in 35/65 (% v/v) H 2 O/CH 3 CN with 1.0 mM solutions of 4-CA in pH 2.0, 4.0, and 6.0 Britton-Robinson buffers − also containing 20 mM FA (Merck) and 0.5 M sodium nitrate (>99.5%, Merck KGaA, Darmstadt, Germany). The cyclic voltammetry measurements were performed in quiescent solutions (with a scan rate of 10, 125, or 250 mV/s), and a MacLab system (ADInstruments, Castle Hill, Australia) connected to a personal computer equipped with the MacLab Echem software (ADInstruments) was employed for the measurements.…”

Section: Methodsmentioning

confidence: 99%

Oxidation of 4-Chloroaniline Studied by On-Line Electrochemistry Electrospray Ionization Mass Spectrometry

2009

View full text Add to dashboard Cite

The oxidation of 4-chloroaniline (4-CA) has been studied by electrochemistry (EC) coupled on-line with electrospray ionization mass spectrometry (ESI-MS) using two electrochemical flow cells of different design. The experimental results, which generally verify previously suggested oxidation pathways for 4-CA, also indicate the presence of an up to now unrecognized comproportionation reaction. The oxidation of 4-CA (m/z 128.2) was found to give rise to the formation of both an oxidized dimer, 4-[(4-chlorophenyl)imino]-2,5-cyclohexadien-1-imine (m/z 217.2), and a reduced dimer, 4-amino-4'-chlorodiphenylamine (m/z 219.2), in addition to a dimer intermediate (m/z 253.2). The unexpected formation of the reduced dimer is shown to stem from a comproportionation reaction involving 4-CA and the oxidized dimer. The presence of the latter reaction was clearly seen by comparing results obtained with two thin-layer flow cells, both with conversion efficiencies of 50% under mass transport controlled conditions but of different design with respect to the influence of the counter electrode reaction on the reaction at the working electrode. The experimental results demonstrate that the formation of the reduced dimer is favored by a decrease in the local pH in the flow cell, and the influence of the pH on the oxidation of 4-CA was also investigated in the pH range between 2.0 and 6.0 using off-line voltammetry. It is concluded that EC/ESI-MS is a powerful tool for the study of the present type of reactions and that studies of the reaction pathways of these systems are best carried out under noncoulometric experimental conditions as the latter facilitates the detection of reaction intermediates. Comproportionation reactions, similar to the reaction present in the 4-CA system, can also be expected to be present during the formation of conducting polymers such as polyaniline and polypyrrole.

show abstract

Section: Methodsmentioning

confidence: 99%

Oxidation of 4-Chloroaniline Studied by On-Line Electrochemistry Electrospray Ionization Mass Spectrometry

2009

View full text Add to dashboard Cite

show abstract

“…Miconazole Nitrate (MIC) an imidazole antifungal agent that is used topically and by intravenous infusion, miconazole nitrate is the nitrate salt form of miconazole, an antifungal synthetic derivative of imidazole and used in the treatment of candidal skin infections. A review of the literature showed that methods reported for the determination of (MIC) alone or in combinations were spectrophotometry [21][22][23][24][25][26][27][28], HPLC [29][30][31][32][33][34][35], HPTLC [31,[36][37][38], gas chromatography [39,40], and electrochemical methods [41]. Gentamicin (GM) is a mixture of isomeric aminoglycoside antibiotics (gentamicin C 1 , gentamicin C 1A , and gentamicin C 2 ) produced by Micromonospora purpurea or M. echinospora.…”

Section: Introductionmentioning

confidence: 99%

Application of TLC-Spectrodensitometric and Chemometric Methods for Determination of Momenta® Cream: A Comparative Study Applied on Ternary Mixture

Salem¹,

MA²,

SM³

et al. 2021

austinjanalpharmchem

View full text Add to dashboard Cite

A comparative study for the validation and advancement of two analytical approaches applied for the simultaneous determination of Mometasone Furoate (MF), Miconazole Nitrate (MIC) and Gentamicin (GM) formulated in Momenta® cream. The first approach was TLC-spectrodensitometric method, which was advanced by separating the three components on TLC aluminum plates coated with silica gel 60 F254 using chloroform: methanol: formic acid (4:0.3:0.15, v/v/v) as a mobile phase, then scanned at 254nm using Camage TLC scanner 3 operated in reflectance-absorbance mode. The second approach was the chemometric method using two models: Partial Least Squares (PLS) and Principle Component Regression Model (PCR). The proposed approaches were validated according to ICH guidelines and were applied for the determination of the ternary mixtures in their analytical mixtures and pharmaceutical preparation.

show abstract

“…A survey of the literature revealed that several analytical methods have been reported for the determination of the studied drugs in the pure drug form, pharmaceutical dosage forms and biological samples using liquid chromatography, either in single or combined form [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18], capillary zone electrophoresis methods [19], electrochemical methods [20], non-aqueous titration [2], spectrofluorimetric methods [16,21] and spectrophotometric methods [21][22][23][24][25][26][27][28][29][30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Optimized and validated spectrophotometric determination of two antifungal drugs in pharmaceutical formulations using an ion-pair complexation reaction

Gouda

Sheikh

Amin

et al. 2016

Journal of Taibah University for Science

View full text Add to dashboard Cite

Simple, rapid, cost-effective, sensitive and extractive spectrophotometric methods were developed for the determination of two antifungal drugs (i.e., sertaconazole nitrate (SER) and miconazole nitrate (MCO)) in pure and dosage forms. The methods are based on the formation of ion-pair complexes between the drugs and acid dyes (i.e., bromocresol purple (BCP), bromophenol blue (BPB) and methyl orange (MO)) in acidic buffer solutions. The formed complexes were extracted with chloroform and measured at 410, 416 and 427 nm for SER and at 408, 415 and 426 nm for MCO using BCP, BPB and MO, respectively. The analytical parameters and their effects on the reported systems were investigated. Beer's law was obeyed in the 1.0-20 and 1.0-24 g mL −1 ranges for SER and MCO, respectively. The composition of the ion pairs was determined to be 1:1. The molar absorptivity, Sandell sensitivity, limits of detection and limits of quantification were calculated. Other method validation parameters, such as precision, accuracy, robustness, ruggedness and selectivity, were satisfactory. The proposed methods have been successfully applied for the analysis of the studied drugs in their pure and dosage forms. Statistical comparison of the results with the reference methods indicated excellent agreement and no significant difference in accuracy and precision.

show abstract

Voltammetric characteristics of miconazole and its cathodic stripping voltammetric determination

Cited by 7 publications

References 13 publications

Oxidation of 4-Chloroaniline Studied by On-Line Electrochemistry Electrospray Ionization Mass Spectrometry

Oxidation of 4-Chloroaniline Studied by On-Line Electrochemistry Electrospray Ionization Mass Spectrometry

Application of TLC-Spectrodensitometric and Chemometric Methods for Determination of Momenta® Cream: A Comparative Study Applied on Ternary Mixture

Optimized and validated spectrophotometric determination of two antifungal drugs in pharmaceutical formulations using an ion-pair complexation reaction

Contact Info

Product

Resources

About