New enamine derivatives of lapachol and biological activity

Oliveira, Mailcar F.; Lemos, Telma L. G.; Mattos, Marcos Carlos de; Segundo, Taciana A.; Santiago, Gilvandete Maria Pinheiro; Braz-Filho, Raimundo

doi:10.1590/s0001-37652002000200004

Cited by 74 publications

(46 citation statements)

References 6 publications

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“…( Colins et al, 1997;Cienfuegos;Vaitsman, 2000;Alencar et al, 1990) e a identifi cação das substâncias foi realizada pela interpretação dos respectivos espectros de massa e por comparação com espectros de massa de banco de dados e com dados da literatura (Adams, 1989). Os bioensaios foram desenvolvidos usando metodologia descrita (Oliveira et al, 2002) feitos em triplicas e em diferentes concentrações (1000, 500, 250, 100, 50 e 10 ppm) utilizando larvas dos mosquitos Aedes aegypti e Culex quinquefasciatus no terceiro estádio de vida (Hamburger;Hostettmann,1991;McLaughlin;Anderson, 1988;Cepleanu, 1993 com água para 20 mL. Na mistura foram adicionadas 10 larvas, sendo contadas as larvas vivas após 24 h. Paralelamente foram feitos controles positivos utilizando o larvicida Temefós, e em branco utilizando-se água + DMSO 2%.…”

Section: Methodsunclassified

Estudo químico-biológico dos óleos essenciais de Hyptis martiusii, Lippia sidoides e Syzigium aromaticum frente às larvas do Aedes aegypti

Costa¹,

Rodrigues²,

Angélico³

et al. 2005

Rev. bras. farmacogn.

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"Chemical-biological study of the essential oils of Hyptis martiusii, Lippia sidóides and Syzigium aromaticum against larvae of Aedes aegypti and Culex quinquefasciatus." The interest for a biological assay against larvae of Aedes aegypti and Culex quinquefasciatus is due to the fact that these species are distributed by the whole national territory, being therefore an activity carried out by countless researchers of Brazil. The essential oils of Syzigium aromaticum, Hyptis martiusii and Lippia sidoides were tested in the combat of the transmitter of the dengue and of the fi lariosis, using larvae of third stadium were exposed in triplicate to different concentrations (1000, 500, 250, 100, 50, 25 and 10 ppm). The larvicidal activity was observed after ten minutes of the beginning of the treatment, in the end showed very signifi cant results, with mortality potentials of up to 100% of the tested larvae, indicating accentuated toxical effects in some representatives of the volatile compounds present in the oils. For the oils of S. aromaticum, L. sidoides and H. martiusii DL 50 of 1,0; 1,0 and 8,0 ppm, respectively, were observed. Keywords:Aedes aegypti, Culex quinquefasciatus, Hyptis martiusii, Lippia sidoides, Syzigium aromaticum, essential oil, larvicidal activity. INTRODUÇÃOO dengue é uma doença infecciosa aguda de curta duração podendo assumir formas graves e letais que vem preocupando as autoridades médico sanitárias de todo o mundo. É transmitida pelos culicídeos do gênero Aedes, especifi camente pela picada do mosquito fêmea infectado. Aedes aegypti é o principal vetor de dengue no mundo, sendo que essa espécie está amplamente distribuída nas regiões tropicais e subtropicais. No Brasil sua existência é conhecida desde o século XVII (Halsted et al., 1997).Nos últimos anos o número de casos registrados e de mortes vítimas da dengue aumentou, visto que o mosquito se tornou resistente aos inseticidas convencionais (Hemingway et al., 2000). Sabe-se que a maneira mais efi caz e ideal para o controle do dengue

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Section: Methodsunclassified

Estudo químico-biológico dos óleos essenciais de Hyptis martiusii, Lippia sidoides e Syzigium aromaticum frente às larvas do Aedes aegypti

Costa¹,

Rodrigues²,

Angélico³

et al. 2005

Rev. bras. farmacogn.

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“…Após 24 horas, à temperatura ambiente, as larvas mortas foram contadas e calculada a percentagem letal e posteriormente a CL 50 . Os testes foram feitos em triplicata (Oliveira et al, 2002). Paralelamente foram feitos testes em branco, utilizandose DMSO e água.…”

Section: Ensaio Larvicidaunclassified

Estudo fitoquímico e avaliação da atividade larvicida de Pterodon polygalaeflorus Benth (Leguminosae) sobre Aedes aegypti

Pimenta¹,

Santiago²,

Arriaga³

et al. 2006

Rev. bras. farmacogn.

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RESUMO:Estudo fi toquímico dos extratos hexânico e metanólico dos frutos de Pterodon polygalaefl orus Benth forneceu três diterpenos furânicos: 6--acetoxivouacapano, 6--hidroxivouacapano e vouacapano, sendo este ultimo relatado pela primeira vez como produto natural. Avaliação da atividade sobre larvas de estágio 3 de Aedes aegypti de 6--acetoxivouacapano, dos extratos hexânico e metanólico dos frutos de P. polygalaefl orus e de seu óleo essencial também é relatada. Apenas o extrato hexânico mostrou boa atividade com CL 50 23,99 0,75 g/mL, podendo ser considerado um potencial agente larvicida.Unitermos: Pterodon polygalaefl orus, Aedes aegypti, diterpenos furânicos, atividade larvicida.ABSTRACT: "Phytotochemical study and evaluation of larvicidal activity of Pterodon polygalaefl orus Benth (Leguminosae) against Aedes aegypti". Chemical investigation of the hexane and methanol extracts of the fruits of Pterodon polygalaefl orus (Leguminosae) resulted in the isolation and identifi cation of furanic diterpenes: 6--acetoxivouacapane, 6--hidroxyvouacapane and vouacapane, which is related by the fi rst time as a natural product. The structures of these compounds were established by spectroscopic analysis, including 2D NMR experiments. The 6--acetoxivouacapane, the hexane and methanol extracts, and the essential oil were evaluated on 3 rd instar larvae of Aedes aegypti and only the hexane extract showed good larvicidal activity with LC 50 23.99 0.75 g/mL.

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“…Due to its ubiquity and beauty, the species was designated the national flower of Brazil and is the emblem of the Brazilian Botanical Society (Gentry 1992b). In addition to its ornamental value (Lorenzi 1992), the species is important for the timber industry, as well as for the pharmaceutical industry, which uses it for a variety of purposes (Gentry 1992a, Lorenzi 1992, including cancer-related research (Oliveira et al 2002;Salustiano et al 2010). This species is reportedly hexaploid, with 2n=120 chromosomes, presenting monoembryonic populations (Sampaio 2010) and populations with high percentages of polyembryonic seeds (Mendes-Rodrigues et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Self-sterility in the hexaploid Handroanthus serratifolius (Bignoniaceae), the national flower of Brazil

et al. 2013

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Polyploidization is common among angiosperms and might induce typically allogamous plants to become autogamous (self-compatible, relying on sexual self-fertilization) or apomictic (achieving asexual reproduction through seeds). This work aimed to determine whether neopolyploidy leads to the breakdown of the self-incompatibility system in the hexaploid non-apomictic species Handroanthus serratifolius (Vahl) S. Grose, through analyses of its floral biology, pollination biology and breeding system. Although anthesis lasted for three days, increasing the overall floral display, receptivity decreased as of the second day. Centridini and Euglossini bees were the main pollinators, and low nectar availability (1.95 ± 1.91 μl/flower) might have obliged them to visit multiple flowers. We observed low reproductive efficacy. That might be explained by self-sterility and by the great number of flowers per individual, which could increase the frequency of geitonogamy. Ovule penetration by the pollen tubes in self-pollinated pistils with posterior abscission indicated late-acting self-incompatibility in H. serratifolius, as observed in other diploid Bignoniaceae species, although inbreeding depression cannot be excluded. The self-sterility found in the monoembryonic, hexaploid individuals studied here contrasts with the results for other neopolyploid Handroanthus and Anemopaegma species, which are often autogamous and apomictic. Our results suggest that neopolyploidy is not the main factor leading to self-fertility in Handroanthus.Key words: apomixis, late-acting self-incompatibility, monoembryony, polyploidy, Tabebuia serratifolia Acta Botanica Brasilica 27(4): 714-722. 2013. Self-sterility in the hexaploid Handroanthus serratifolius(Bignoniaceae), the national flower of Brazil

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New enamine derivatives of lapachol and biological activity

Cited by 74 publications

References 6 publications

Estudo químico-biológico dos óleos essenciais de Hyptis martiusii, Lippia sidoides e Syzigium aromaticum frente às larvas do Aedes aegypti

Estudo químico-biológico dos óleos essenciais de Hyptis martiusii, Lippia sidoides e Syzigium aromaticum frente às larvas do Aedes aegypti

Estudo fitoquímico e avaliação da atividade larvicida de Pterodon polygalaeflorus Benth (Leguminosae) sobre Aedes aegypti

Self-sterility in the hexaploid Handroanthus serratifolius (Bignoniaceae), the national flower of Brazil

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