Interactions between cationic liposomes and drugs or biomolecules

Carmona-Ribeiro, Ana Maria

doi:10.1590/s0001-37652000000100005

Cited by 28 publications

(35 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, one should recall the bioactivity previously reported for DODAB dispersions (3,5,6). They are microbicides and exhibit a remarkable differential cytotoxicity when tested against mammalian cells in culture (43), a requirement for drugs with potential use in therapy (3,6,43). Therefore, drug self-assembly at DODAB bilayer fragments appears a convenient combination for further developments.…”

Section: Fig 1 Optical Spectra Of Amphotericin B (6 µG/ml) In Watermentioning

confidence: 96%

Synthetic Bilayer Fragments for Solubilization of Amphotericin B

Vieira

Carmona-Ribeiro

2001

Journal of Colloid and Interface Science

Self Cite

View full text Add to dashboard Cite

Section: Fig 1 Optical Spectra Of Amphotericin B (6 µG/ml) In Watermentioning

confidence: 96%

Synthetic Bilayer Fragments for Solubilization of Amphotericin B

Vieira

Carmona-Ribeiro

2001

Journal of Colloid and Interface Science

Self Cite

View full text Add to dashboard Cite

“…Bilayer [184,184,186], multibilayer [186,205], monolayer-covered [40,187], monolayer plus bilayer(s) covered particles [187 -189], a layer of adhered vesicles [72][73][74]78] could occur on the particle depending on nature of vesicles and particles involved (recall Fig. (2)).…”

Section: Natural and Synthetic Lipids On Surfaces Particles And Cellsmentioning

confidence: 99%

Bilayer-Forming Synthetic Lipids: Drugs or Carriers?

Carmona-Ribeiro

2003

CMC

View full text Add to dashboard Cite

Since their introduction as bilayer-forming synthetic compounds in the eighties, dioctadecyldimethylammonium (DODA) and dihexadecylphosphate (DHP) salts have found many uses in strategic, applied areas. In particular, DODA chloride or bromide vesicles interacted with negatively charged prokaryotic or eukaryotic cells, yielding adsorption isotherms of high affinity for the cell surface, causing cell adhesion and flocculation, changing the cell surface charge from negative to positive, and causing loss of cell viability over DODA concentration ranges that depended on the cell type being tested. This work reviews data on DODA effects on cell viability (bacteria, fungus and cultured mammalian cells) to propose DODA salts as effective anti-microbial agents that exhibit differential cytotoxicity in vitro and, therefore, deserve to be investigated as potential drugs. The full utility of these inexpensive synthetic bilayers and bilayer fragments able to act as drugs themselves and, simultaneously, as drug, gene or vaccine carriers remains hitherto unexplored.

show abstract

“…[174][175][176][177][178][256][257][258][259] In addition, both DODAB and DHP BF were employed to stabilize hydrophobic drug particles in water so that formulations at high drug to lipid molar ratios could also be obtained. 196,203 In these formulations, the electrostatic attraction between the charged drug particle and the oppositely charged BF essentially drives the coverage with a lipid layer.…”

Section: Nanomedicines Based On Lipidsmentioning

confidence: 99%

Biomimetic Systems in Nanomedicine

Carmona-Ribeiro¹

2014

Frontiers in Nanobiomedical Research

Self Cite

View full text Add to dashboard Cite

Mimicking Nature has been a major source of inspiration for producing novel pharmaceutical formulations with improved therapeutic index and reduced toxicity. In Nature, the self-assembly of biomolecules driven by intermolecular interactions leads to highly functional, nanosized biological machines. Novel directions for drug and vaccine delivery to cure or prevent disease somehow have to copy Mother Nature wisdom. In this chapter, smart nanocarriers produced from the self-assembly of biocompatible polymers, lipids or hybrid nanoparticles (NPs) are presented and some of their applications in antimicrobial chemotherapy, drug and vaccine delivery discussed. Self-Assembly and Intermolecular InteractionsWeak intermolecular interactions are important for the rational design of novel biomimetic materials. Main weak interactions are the van der Waals interaction (ion-dipole, dipole-dipole, dipole-induced dipole interactions, induced-dipole induced-dipole), the electrostatic interaction, the hydrogen bonds, the hydrophobic interactions and the steric repulsion. 1,2 The weak but cooperative hydrogen bonding between the two strands of double-stranded DNA is a wise approach used by Nature to keep the strands together without hampering replication and transcription. 3 The repulsion between nonpolar Handbook of Nanobiomedical Research Downloaded from www.worldscientific.com by UNIVERSITY OF BIRMINGHAM LIBRARY -INFORMATION SERVICES on 03/21/15. For personal use only.

show abstract

Interactions between cationic liposomes and drugs or biomolecules

Cited by 28 publications

References 17 publications

Synthetic Bilayer Fragments for Solubilization of Amphotericin B

Synthetic Bilayer Fragments for Solubilization of Amphotericin B

Bilayer-Forming Synthetic Lipids: Drugs or Carriers?

Biomimetic Systems in Nanomedicine

Contact Info

Product

Resources

About