Bovine S protein (vitronectin) increases phagocytosis of Streptococcus dysgalactiae

Filippsen, Laerte Francisco

doi:10.1590/s0001-37141999000100003

Cited by 2 publications

(1 citation statement)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, binding of S. dysgalactiae to vitronectin was implicated in phagocytosis. Exposure of S. dysgalactiae to vitronectin before phagocytic assays increased phagocytosis by bovine polymorphonuclear neutrophils [ 50 ].…”

Section: Pathogenesis and Virulence Factorsmentioning

confidence: 99%

The Role of Streptococcus spp. in Bovine Mastitis

et al. 2021

View full text Add to dashboard Cite

The Streptococcus genus belongs to one of the major pathogen groups inducing bovine mastitis. In the dairy industry, mastitis is the most common and costly disease. It not only negatively impacts economic profit due to milk losses and therapy costs, but it is an important animal health and welfare issue as well. This review describes a classification, reservoirs, and frequencies of the most relevant Streptococcus species inducing bovine mastitis (S. agalactiae, S. dysgalactiae and S. uberis). Host and environmental factors influencing mastitis susceptibility and infection rates will be discussed, because it has been indicated that Streptococcus herd prevalence is much higher than mastitis rates. After infection, we report the sequence of cow immune reactions and differences in virulence factors of the main Streptococcus species. Different mastitis detection techniques together with possible conventional and alternative therapies are described. The standard approach treating streptococcal mastitis is the application of ß-lactam antibiotics. In streptococci, increased antimicrobial resistance rates were identified against enrofloxacin, tetracycline, and erythromycin. At the end, control and prevention measures will be considered, including vaccination, hygiene plan, and further interventions. It is the aim of this review to estimate the contribution and to provide detailed knowledge about the role of the Streptococcus genus in bovine mastitis.

show abstract

Section: Pathogenesis and Virulence Factorsmentioning

confidence: 99%

The Role of Streptococcus spp. in Bovine Mastitis

et al. 2021

View full text Add to dashboard Cite

show abstract

Vitronectin in bacterial pathogenesis: a host protein used in complement escape and cellular invasion

Singh

Riesbeck³

2010

Molecular Microbiology

174

232

View full text Add to dashboard Cite

SummaryThe multifunctional human glycoprotein vitronectin (Vn) plays a significant role in cell migration, tissue repair and regulation of membrane attack complex (MAC) formation. It also promotes neutrophil infiltration and, thus, enhances the inflammatory process during infection. In the host, a balanced homeostasis is maintained by Vn due to neutralization of the selfreactivity of the MAC. On the other hand, Vn bound to the bacterial surface protects from MAC-mediated lysis and enhances adhesion. Gram-negative bacterial pathogens including Moraxella catarrhalis, Haemophilus influenzae and Neisseria gonorrhoeae use Vn recruitment to prevent MAC deposition at their surface. Moreover, Gram-positive bacterial pathogens such as Streptococcus pneumoniae and S. pyogenes utilize Vn for effective adhesion to host cells and subsequent internalization. Vitronectin has an ArgGly-Asp (RGD) sequence for binding the host cell integrin receptors and a separate bacterial-binding domain for pathogens, and thus more likely functions to cross-link bacteria and epithelial cells. Once bacteria are attached to the vitronectin-integrin complex, various host cell-signalling events are activated and promote internalization. In this review, we focus on the important roles of vitronectin in bacterial pathogenesis and describe different strategies used by pathogens to evade the host response by the help of this intriguing molecule.

show abstract

Bovine S protein (vitronectin) increases phagocytosis of Streptococcus dysgalactiae

Cited by 2 publications

References 19 publications

The Role of Streptococcus spp. in Bovine Mastitis

The Role of Streptococcus spp. in Bovine Mastitis

Vitronectin in bacterial pathogenesis: a host protein used in complement escape and cellular invasion

Contact Info

Product

Resources

About