Does treatment with dutasteride or finasteride has impact on renal morphology? Experimental study

Silva, Marcello Henrique Araujo Da; Estrada, João Henrique Duque Reis; Gregório, Bianca Martins; Sampaio, Francisco J.B.; Souza, Diogo Benchimol de

doi:10.1590/acb360703

Cited by 3 publications

(3 citation statements)

References 31 publications

(55 reference statements)

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“…We consider that in patients with renal disease, the level of plasma albumin decreases due to proteinuria, and then the colloid osmotic pressure in the blood vessels decreases, and the interstitial fluid increases, resulting in edema. In the future, the specific mechanisms of lower limb edema in patients with Eg5 deficiency can be explored through the examination of urea and creatinine in blood, and protein contents in the urine [ 58 ].…”

Section: Discussionmentioning

confidence: 99%

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Kinesin-5 Eg5 is essential for spindle assembly, chromosome stability and organogenesis in development

et al. 2022

Cell Death Discov.

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Chromosome stability relies on bipolar spindle assembly and faithful chromosome segregation during cell division. Kinesin-5 Eg5 is a plus-end-directed kinesin motor protein, which is essential for spindle pole separation and chromosome alignment in mitosis. Heterozygous Eg5 mutations cause autosomal-dominant microcephaly, primary lymphedema, and chorioretinal dysplasia syndrome in humans. However, the developmental roles and cellular mechanisms of Eg5 in organogenesis remain largely unknown. In this study, we have shown that Eg5 inhibition leads to the formation of the monopolar spindle, chromosome misalignment, polyploidy, and subsequent apoptosis. Strikingly, long-term inhibition of Eg5 stimulates the immune responses and the accumulation of lymphocytes in the mouse spleen through the innate and specific immunity pathways. Eg5 inhibition results in metaphase arrest and cell growth inhibition, and suppresses the formation of somite and retinal development in zebrafish embryos. Our data have revealed the essential roles of kinesin-5 Eg5 involved in cell proliferation, chromosome stability, and organogenesis during development. Our findings shed a light on the cellular basis and pathogenesis in microcephaly, primary lymphedema, and chorioretinal dysplasia syndrome of Eg5-mutation-positive patients.

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Section: Discussionmentioning

confidence: 99%

“…CZ1) were raised and maintained in 14 h light/10 h dark conditions at 28.5 °C. Fish lines were maintained by the standard guidelines [ 58 ]. Zebrafish embryos were obtained from the natural spawning of wild-type fish and collected at different stages according to the standard guidelines [ 28 , 29 ].…”

Section: Methodsmentioning

confidence: 99%

Kinesin-5 Eg5 is essential for spindle assembly, chromosome stability and organogenesis in development

et al. 2022

Cell Death Discov.

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“…50 Animal research has shown that 5ARI treatment can result in morphological and functional damage to kidneys. 68 Baig et al found Type I and Type III collagen were increased, respectively, in the interstitial cortical region and glomerulus of finasteride-treated rats, with the latter leading to glomerulosclerosis. The overall percentage of collagen in sampled kidney tissue of finasteride-treated rats was more than double that of controls.…”

Section: Ischemia-reperfusion Injury In Kidney Diseasesmentioning

confidence: 97%

From organ injury to disability: a proposed model for 5-alpha reductase inhibitor syndrome

Montaigne¹

2022

Preprint

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Persistent dysfunctions emerging from use and discontinuation of 5-alpha reductase inhibitors (PD-5ARI) may be explained as the aftermath of a pathological recovery from microvasculopathy or ischemia in multiple systems. Focusing on persistent sexual dysfunction, the most common class of symptoms: 5ARIs’ inhibition of angiogenesis leads to stress on penile microvasculature, depriving the tissue of blood supply and oxygen. These hypoxic conditions lead to tissue injury and atrophy, triggering a pathological recovery that further alters penile tissue, including smooth muscle loss, fibrosis, damage to vascular architecture and impairment of neural pathways supporting arousal and erectile function. This damaging cascade may result in severe and lasting sexual dysfunction. Persistent neuropsychiatric, cognitive, sensory and sleep dysfunctions emerging from 5ARI treatment may similarly be explained as pathological responses to microvasculopathy or ischemia in supporting structures, particularly those in the limbic system. Systemic spread is proposed to arise from a vicious cycle of tissue injury, oxidative stress and proinflammatory activity which spreads via the vascular network, leading to systemic endothelial dysfunction. The latter may in turn set off a damaging cascade in other organs and tissues. Risks of developing PD-5ARI may arise from 5ARI-mediated disruptions of vascular tone, angiogenesis and neoangiogenesis. Pharmacovigilance data, animal studies and human studies provide converging evidence for the proposed etiopathology. It is, moreover, consistent with variable presentation and severity of PD-5ARI symptoms; irreversibility of symptoms; typically normal results of clinical lab tests; and resistance to treatment.

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Effects of algerian nettle ( Urtica dioica L.) on benign prostatic hyperplasia and their mechanism of action elucidation: in vivo and in silico approaches

Bougueroua,

Boufadi,

Latreche

et al. 2023

Natural Product Research

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Does treatment with dutasteride or finasteride has impact on renal morphology? Experimental study

Cited by 3 publications

References 31 publications

Kinesin-5 Eg5 is essential for spindle assembly, chromosome stability and organogenesis in development

Kinesin-5 Eg5 is essential for spindle assembly, chromosome stability and organogenesis in development

From organ injury to disability: a proposed model for 5-alpha reductase inhibitor syndrome

Effects of algerian nettle ( Urtica dioica L.) on benign prostatic hyperplasia and their mechanism of action elucidation: in vivo and in silico approaches

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