Poor glycemic control can lead to an early appearance of atherosclerosis in patients with type 1 diabetes - Can this be avoided by effective educational programs?

Rodacki, Melanie

doi:10.1590/2359-3997000000304

Cited by 1 publication

(1 citation statement)

References 23 publications

(22 reference statements)

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“…Patients with diabetes mellitus have a 2-to-4-fold higher risk of ischemic disease than their nondiabetic counterparts (1). In individuals with type 1 diabetes, the risk appears to be even higher (2). Platelet hyperreactivity has been postulated as a potential contributor to the increased thrombogenicity observed in the diabetic population.…”

Section: Introductionmentioning

confidence: 99%

Streptozotocin-Induced Diabetes Mellitus – a Paradox of High Intrinsic Platelet Reactivity and Low In Vitro Platelet Aggregation

et al. 2019

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Context. Studies of platelet function in diabetics are inconsistent, some studies reporting higher platelet reactivity, while others showed no change.Objective. We aimed to evaluate platelet indices and in vitro platelet aggregation in rats with long-lasting (28 weeks) diabetes mellitus.Design. Twelve controls and 14 diabetic rats were investigated. Diabetes was induced in 11-week-old rats using streptozotocin (60 mg/kg,i.p.). Platelet indices and in vitro adenosine diphosphate (ADP)-, protease-activated receptor 4 (PAR4) agonist-, and arachidonic acid (AA)-induced platelet aggregation were assessed at the age of 38 weeks.Results. Compared to controls, diabetic rats presented lower platelet count and plateletcrit (both p≤0.001), and higher mean platelet volume (p<0.01). ADP-(p=0.04) and AA-induced (p<0.01) platelet aggregation were lower in diabetic compared with control rats, whereas PAR4 agonistinduced platelet aggregation was similar between the two groups (p=1.00).Conclusions. This study demonstrates a paradox of high intrinsic platelet reactivity and low in vitro ADP-and AA-induced platelet aggregation in diabetic rats compared with non-diabetic controls. The relevance of in vitro platelet aggregation to the contribution of platelets to in vivo thromboembolic events in diabetic rats remains questionable.

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Section: Introductionmentioning

confidence: 99%