Does insulin resistance increase thyroid volume in patients with polycystic ovary syndrome?

Abstract

Objective: To investigate the effect of gonadotropin, sex hormone levels and insulin resistance (IR) on thyroid functions and thyroid volume (TV) in polycystic ovary syndrome (PCOS). Subjects and methods: Sixty nine new diagnosed PCOS patients (age 24.82 ± 6.17) and 56 healthy control female (age 26.69 ± 5.25) were involved to the study. Fasting plasma glucose, lipid profile, insulin, thyroid stimulating hormone (TSH), free thyroxine (fT4), estradiol (E2), luteinizing hormone (LH), follicle stimulating hormone levels and urine iodine were measured in all participants. Thyroid and pelvic ultrasound were performed in all participants. Results: Insulin, HOMA-IR, LH, E2 and TV were higher in PCOS group (p < 0.05). TV was significantly higher in PCOS patients with IR compared to non-IR PCOS patients (p < 0.001), while TSH, fT4, and urine iodine levels were similar between these groups (p > 0.05). There was a negative correlation between E2 and TSH (p < 0.05) and a positive correlation between TSH and TV (p < 0.05). There was a significant positive correlation between TV and LH, insulin, HOMA-IR (p < 0.05). Conclusion: This study showed that TV was increased in patients with insulin resistance but differences in TSH and LH levels may affect TV changes as well. Arch Endocrinol Metab. 2017;61(2):145-51.

The Association Between Thyroid Volume and Insulin Resistance in Patients with Non-Functional Adrenal Incidentaloma

“…Increased TV was reported in patients with IR (25). In the previous study by the authors involving Polycystic Ovary Syndrome patients, significantly increased TV was noted in patients with IR compared to those without IR (TV in insulin-resistant patients was 14.43±2.91, TV in patients without IR was 11.68±2.72, p=0.000) (26). The present study revealed that the frequency of thyroid nodules was higher but not statistically significant (64.4/53.5%, p=0.639), and the mean TV was significantly higher in the NFAI group (13.30±5.95 and 5.99±3.04, respectively, p<0.001).…”

Significance of Monocyte Chemoattractant Protein-1, Thyroid Hormones and Other Clinical Manifestations in Iraqi Patients With Polycystic Ovarian Syndrome

“…PCOS can be considered a genetic disorder just like T2 DM [27], and it has been occurred in one of each five women within the reproductive age [28,29]. On the other hand, it was found that high Estradiol levels may affect the thyroid cells [30]. In hyperandrogenemia, Testosterone level measurement is very important [31].…”

Relación entre hipotiroidismo y síndrome de ovario poliquístico

“…Contrario a la obesidad, la resistencia a la insulina no ha demostrado tener asociación estadísticamente significativa con la presencia de hipotiroidismo 28 ; no obstante, se ha encontrado una fuerte asociación con el incremento del volumen tiroideo 33 . Esto se explicaría por el efecto estimulante de la hiperinsulinemia resultante en la proliferación y la hiperplasia celular, junto con la inhibición de los procesos apoptóticos 34 .…”