Low carbohydrate high fat diets: when models do not match reality

Caminhotto, Rennan de Oliveira; Lima, Fábio Bessa

doi:10.1590/2359-3997000000177

Cited by 3 publications

(2 citation statements)

References 12 publications

(5 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…<www.sciencedaily.com/releases/ 2016/02/160218114753.htm> . It is noteworthy that these conclusions were based on mouse studies, which, as has been discussed, are irrelevant to humans [4,5]. But how can we explain the discrepancy between the clinical results from humans and the experimental results from mice?…”

Section: Introductionmentioning

confidence: 99%

The mystery of the ketogenic diet: benevolent pseudo-diabetes

Blagosklonny

2019

Cell Cycle

View full text Add to dashboard Cite

Designed a century ago to treat epilepsy, the ketogenic diet (KD) is also effective against obesity and diabetes. Paradoxically, some studies in rodents have found that the KD seemingly causes diabetes, contradicting solid clinical data in humans. This paradox can be resolved by applying the concept of starvation pseudo-diabetes, which was discovered in starved animals almost two centuries ago, and has also been observed in some rapamycin-treated rodents. Intriguingly, use of the KD and rapamycin is indicated for a similar spectrum of diseases, including Alzheimer’s disease and cancer. Even more intriguingly, benevolent (starvation) pseudo-diabetes may counteract type 2 diabetes or its complications.

show abstract

Section: Introductionmentioning

confidence: 99%

The mystery of the ketogenic diet: benevolent pseudo-diabetes

Blagosklonny

2019

Cell Cycle

View full text Add to dashboard Cite

show abstract

“…At about the third day of glucose deprivation, the brain begins escalating its dependence on ketones as an energy substrate, and by 96 hours, the brain can be using ketones for most of its ATP needs [ 64 ]. In fact, ketones can serve as ATP substrates to supply as much as 70% of the brain's energy to meet demand [ 65 , 66 ]. In cases of dementia, including Alzheimer's disease, elevated serum ketones (ketosis) are showing promise as a viable treatment [ 67 – 69 ], and the underlying mechanism is quite fascinating.…”

Section: Endogenous Ketone Generationmentioning

confidence: 99%

Potential Synergies ofβ-Hydroxybutyrate and Butyrate on the Modulation of Metabolism, Inflammation, Cognition, and General Health

Cavaleri¹,

Bashar²

2018

Journal of Nutrition and Metabolism

108

View full text Add to dashboard Cite

The low-carbohydrate high-fat diet (LCHFD), also known as the ketogenic diet, has cycled in and out of popularity for decades as a therapeutic program to treat metabolic syndrome, weight mismanagement, and drug-resistant disorders as complex as epilepsy, cancer, dementia, and depression. Despite the benefits of this diet, health care professionals still question its safety due to the elevated serum ketones it induces and the limited dietary fiber. To compound the controversy, patient compliance with the program is poor due to the restrictive nature of the diet and symptoms related to energy deficit and gastrointestinal adversity during the introductory and energy substrate transition phase of the diet. The studies presented here demonstrate safety and efficacy of the diet including the scientific support and rationale for the administration of exogenous ketone bodies and ketone sources as a complement to the restrictive dietary protocol or as an alternative to the diet. This review also highlights the synergy provided by exogenous ketone, β-hydroxybutyrate (BHB), accompanied by the short chain fatty acid, butyrate (BA) in the context of cellular and physiological outcomes. More work is needed to unveil the molecular mechanisms by which this program provides health benefits.

show abstract

Rapamycin for longevity: opinion article

Blagosklonny

2019

Aging

135

View full text Add to dashboard Cite

From the dawn of civilization, humanity has dreamed of immortality. So why didn’t the discovery of the anti-aging properties of mTOR inhibitors change the world forever? I will discuss several reasons, including fear of the actual and fictional side effects of rapamycin, everolimus and other clinically-approved drugs, arguing that no real side effects preclude their use as anti-aging drugs today. Furthermore, the alternative to the reversible (and avoidable) side effects of rapamycin/everolimus are the irreversible (and inevitable) effects of aging: cancer, stroke, infarction, blindness and premature death. I will also discuss why it is more dangerous not to use anti-aging drugs than to use them and how rapamycin-based drug combinations have already been implemented for potential life extension in humans. If you read this article from the very beginning to its end, you may realize that the time is now.

show abstract

Low carbohydrate high fat diets: when models do not match reality

Cited by 3 publications

References 12 publications

The mystery of the ketogenic diet: benevolent pseudo-diabetes

The mystery of the ketogenic diet: benevolent pseudo-diabetes

Potential Synergies ofβ-Hydroxybutyrate and Butyrate on the Modulation of Metabolism, Inflammation, Cognition, and General Health

Rapamycin for longevity: opinion article

Contact Info

Product

Resources

About