Reciprocal changes of serum adispin and visfatin levels in patients with type 2 diabetes after an overnight fast

Legakis, Ioannis; Mantzouridis, Timos; Bouboulis, George; Chrousos, George P.

doi:10.1590/2359-3997000000147

Cited by 22 publications

(14 citation statements)

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“…Therefore, the discrepancies of the data might be due to the difference of race, degree of obesity, glycemic control, inclusion criteria and the detection methods. Furthermore, consistent with previous studies, the correlation analysis showed a negative correlation between serum adipsin and FPG and HbA1c. Meanwhile, there was a positive correlation between serum adipsin and HOMA‐β, AUC and AIR.…”

Section: Discussionsupporting

confidence: 91%

Relationship between serum adipsin and the first phase of glucose‐stimulated insulin secretion in individuals with different glucose tolerance

Zhou

Ding

et al. 2018

J of Diabetes Invest

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Aims/IntroductionTo detect serum adipsin levels in individuals with different glucose tolerance, and investigate the relationship between adipsisn and the first phase of insulin secretion.Materials and MethodsA total of 56 patients with newly diagnosed type 2 diabetes mellitus, 36 patients with impaired glucose tolerance (IGT) and 45 individuals with normal glucose tolerance were enrolled. Intravenous glucose tolerance tests were carried out to evaluate pancreatic β‐cell function. The serum levels of adipsin, interleukin‐1β and high‐sensitivity C‐reactive protein were assayed.ResultsSerum adipsin levels were significantly lower in the type 2 diabetes mellitus and the IGT patients than those in the normal glucose tolerance group (P < 0.05). The acute insulin response and area under the curve showed a progressive decrease in the normal glucose tolerance and IGT groups, and decreased to the lowest levels in the type 2 diabetes mellitus group (P < 0.05). Adipsin was found to be negatively correlated with waist‐to‐hip ratio, free fatty acid, fasting plasma glucose, 2‐h postprandial plasma glucose, glycated hemoglobin, homeostasis model assessment of insulin resistance, interleukin‐1β and high‐sensitivity C‐reactive protein (P < 0.05 or P < 0.001), and positively correlated with homeostasis model assessment of β‐cell function, high‐density lipoprotein cholesterol, the area under the curve of the first phase insulin secretion and acute insulin response (P < 0.05 or P < 0.001). Stepwise multiple regression analysis showed that homeostasis model assessment for β‐cell function and acute insulin response were independently related to adipsin (P < 0.05).ConclusionsSerum adipsin levels were lower in type 2 diabetes mellitus and IGT patients, and correlated with the first phase of insulin secretion. Adipsin might be involved in the pathology of type 2 diabetes mellitus.

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Section: Discussionsupporting

confidence: 91%

Relationship between serum adipsin and the first phase of glucose‐stimulated insulin secretion in individuals with different glucose tolerance

Zhou

Ding

et al. 2018

J of Diabetes Invest

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“…Speci cally we showed that adipsin was lower in T2D compared to NGT, which was similar to majority [40,[56][57][58] but not all [10,19] previously published research. In addition, this study showed that 2-hour post-glucose load adipsin was lower in T2D compared to NGT.…”

Section: Discussionsupporting

confidence: 90%

Predictors of HbA1c among adipocytokine biomarkers in African American men with varied glucose tolerance

Barengolts¹,

Akbar

Layden

et al. 2020

Preprint

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Background: Adipocytokines are important in type 2 diabetes (T2D). This study explored adipocytokine associations with acute and chronic hyperglycemia in African American Men (AAM). Methods: Fourteen adipocytokines were measured (multiplex assay) in blood samples from men with normal glucose tolerance (NGT) or T2D (drug-naïve MF(-) or using metformin MF(+)). Acute and chronic hyperglycemia were evaluated at 120-minute of OGTT and by HbA1c, respectively. Results: AAM with T2D (N=21) compared to NGT (N=20) were significantly older (59 vs. 54 years) and had higher body mass index (BMI 35 vs. 27 kg/m2) (p<0.01 for both). Fasting and 120-minute OGTT glucose and insulin were higher in T2D than NGT, however, differences did not reach statistical significance after adjusting for age and BMI. In the fasted state, TNF-a, IL-6, PAI-1 (p<0.01 for all) and IL-13, adiponectin, adipsin, lipocalin (p<0.05 for all) were lower in T2D compared to NGT. At 120-minute post-glucose load (acute hyperglycemia) TNF-a, IL-6, IL-13, IL-8, PAI-1, adiponectin, adipsin (p<0.01 for all) and lipocalin, resistin (p<0.05 for both) were lower in T2D than in NGT group. There were no statistical differences for the other adipocytokines including GM-CSF, IL-7, IL-10, IP-10, and MCP-1. Regression analysis (adjusted for age and BMI) showed that fasting IL-8, TNF-a, adiponectin, lipocalin, resistin, adipsin, and PAI-1 were all associated with HbA1c (p<0.05 for all). Further modeling revealed that after adjusting for age, BMI, glucose tolerance status and metformin use, only adipsin remained significantly associated with HbA1c (p=0.004). The model including adipsin, TNF-a, age, BMI, and group designation (i.e. NGT, MF(-), MF(+)) explained 86% of HbA1c variability. Conclusions: The study suggested that adipsin could be independently associated with HbA1c in AAM with varied glucose tolerance. Additional studies should corroborate these data and provide mechanistic insights for enabling adipsin-related discoveries of novel T2D treatment.

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“…Adipsin level showed a decrease in diabetic patients compared to control group (13 ± 11.7 mg/dL vs.18.0 ± 13.4 mg/dL, P = 0.001). These results were confirmed by Legakis et al who reported that the circulating adipsin levels decreased in patients with T2DM (74.30 ± 12.51 pg/mL vs. 117.1 ± 5.03 pg/mL, P < 0.0001) (19). It is also reported that adipsin is a protein of adipose cells, but paradoxically declines in many animal models of obesity and diabetes (9).…”

Section: Discussionsupporting

confidence: 68%

“…Adipose tissue acts not only as energy storage in the body, but also as an endocrine organ that secretes different hormones or adipokines, which circulate in distinct target receptors in many tissues. These adipokines seem to contribute in the pathogenesis of T2DM (19).The different metabolic profile of the adipokines such as fetuin-A and adipsin improve the possible role of the adipose tissue in the energy metabolism and glucose homeostasis in T2DM. Different factors may contribute to fetuin-A regulation in relationship with the pathophysiological consequence in T2DM.…”

Section: Discussionmentioning

confidence: 99%

Serum Fetuin-A and Adipsin Levels in Type II Diabetes Patients

Karajibani

Montazerifar

Sadeghi

et al. 2019

Int J High Risk Behav Addict

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Background: Fetuin-A is a glycoprotein known as a biomarker for diabetes risk. Adipsin or complement factor D (CFD) plays a role in glucose tolerance, and metabolism. Objectives: This study aimed to investigate the concentration of fetuin-A and adipsin in patients with type 2 diabetes mellitus (T2DM) and healthy subjects. Patients and Methods: This case-control study was carried out on 43 patients with T2DM and 41 healthy subjects. Biochemical parameters were determined. Fetuin-A and adipsin levels were measured using ELISA kits. Lipid profile and biochemical factors were measured by spectrophotometric methods. Results: The results showed a trend toward lower fetuin-A and CFD concentrations between the two groups (P < 0.05). There was a significant correlation between the levels of fetuin-A and adipsin (P < 0.0001), FBS and HbA1C (P = 0.02), FBS and creatinine (P = 0.03), and BUN (P < 0.001).There was significant differences according to biochemical levels between the two groups (P < 0.001). Conclusions: The findings suggest that fetuin-A and adipsin levels were decreased in T2DM. It seems that the result of fetuin-A and adipsin levels in the diabetes depends on numerous vague factors. Nevertheless, in comparison with published data the changes of fetuin and adipsin levels in patients with T2DM indicate a complex but not complete role of fetuin-A and adipsin in the pathogenesis of T2DM.

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Reciprocal changes of serum adispin and visfatin levels in patients with type 2 diabetes after an overnight fast

Cited by 22 publications

References 9 publications

Relationship between serum adipsin and the first phase of glucose‐stimulated insulin secretion in individuals with different glucose tolerance

Relationship between serum adipsin and the first phase of glucose‐stimulated insulin secretion in individuals with different glucose tolerance

Predictors of HbA1c among adipocytokine biomarkers in African American men with varied glucose tolerance

Serum Fetuin-A and Adipsin Levels in Type II Diabetes Patients

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