Metabolic syndrome in infertile women with polycystic ovarian syndrome

Abstract

Objective: The aim of the present study was to determine the prevalence of metabolic syndrome (MS) in infertile Iranian women with polycystic ovary syndrome (PCOS) using the ATPIII criteria. Subjects and methods: In this cross-sectional study, 624 women with PCOS were enrolled at a tertiary referral center in Tehran, Iran, between April, 2012 and March, 2013. Diagnosis of MS was according to ATPIII criteria. Also, we divided PCOS patients into following two main groups: (i) with MS (n = 123) and (ii) without MS (n = 501), and then compared variables between two groups. Results: The mean age, body mass index (BMI) and waist circumference were 28.6 ± 4.3 years, 26.7 ± 3.7 kg/m 2 and 85.2 ± 8.7 cm, respectively. The prevalence of MS was 19.7%. Our findings showed that age, BMI, waist circumference and all metabolic parameters were higher in PCOS women with MS than related values in those without MS. The most and least prevalent forms of MS were low level of high density lipoprotein-cholesterol (HDL-C) and hypertension, respectively. Conclusion: It seems the prevalence of metabolic syndrome in our country isn't as high as western countries. The prevalence rate of MS increased with age and BMI. One of the major cardiovascular risk factors, low level of HDL-C, is the most prevalent metabolic abnormality in our participants.

Association between Insulin Resistance and Cardiovascular Risk Factors in Polycystic Ovary Syndrome Patients

“…Acanthosis nigricans, observed in 48.19% of the patients, cannot be forgotten, since a substantial percentage of PCOS patients suffer from this condition and its severity correlates with the degree of IR. 26 Besides that, the metabolic abnormalities in PCOS patients can coincide with the diagnostic components of the MS, 9 in which IR and compensatory hyperinsulinemia also play a crucial role in the physiopathology of the MS. 27 Nevertheless, the prevalence of this syndrome can vary depending on the ethnicity, age, BMI, country, as well as the criteria used in defining both PCOS and the MS. 28 Despite having excluded the analysis the patients' charts with fasting glucose higher than 100 mg/dL, 22.89% of the patients in our study had at least three parameters altered the normalcy standards, which would comply with the MS diagnostic criteria, 9 reinforcing the higher cardiovascular risk in PCOS women.…”

Association of polycystic ovary syndrome with metabolic syndrome and gestational diabetes: Aggravated complication of pregnancy

“…Apparently, the incidence of MS among PCOS patients seems to be affected also by the geographical region as well as the habits of the patients as it has been recently shown that in Iran the incidence of MS in the Iranian PCOS patients (19.7%) is less than that seen in United States (33–46%) (8), India (9) and Brazil (10) and its incidence increases with age and body mass index (BMI), with the most prevalent condition being low/high density lipoprotein-cholesterol (11). On the other hand, the incidence of MS was reported to be lower among European women with PCOS (12,13).…”

Postmenopause and Metabolic Syndrome

“…(28). Insulin resistance may result in chronic anovulation and infertility with hyperandrogenism (29). Metabolic syndrome is associated with hypogonadism in both men and women.…”