Relationship between mean platelet volume and vitamin D deficiency in gestational diabetes mellitus

Gür, Esra Bahar; Karadeniz, Muammer; Genç, Mine; Eskicioğlu, Fatma; Yalçın, Murat; Hepyilmaz, Irem; Güçlü, Serkan

doi:10.1590/2359-3997000000063

Cited by 14 publications

(10 citation statements)

References 33 publications

(42 reference statements)

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“…In female patients with chronic diseases, vit D levels <20 mg/dl an inverse linear relationship with MPV has been demonstrated ( 53 ). The same relationship was described at even lower vit D levels, <10 mg/dl ( 31 , 54 ), in pregnant women with gestational diabetes mellitus (DM) ( 55 ) and in patients with fibromyalgia ( 56 ), although in the latter study no differences in MPV from the control subjects were noted with vit D levels 20–30 mg/dl. Our study showed that low vit D levels are associated with low MPV in children with non-influenza RTI.…”

Section: Discussionmentioning

confidence: 56%

Relationship Between Vitamin D Level and Platelet Parameters in Children With Viral Respiratory Infections

et al. 2022

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Apart from their classical roles, both platelets and vitamin D play important roles in inflammation and infectious diseases. This study evaluated the platelet response to viral respiratory tract infection in children aged 4–16 years, 32 with influenza, 27 with non-influenza viral infection tested by nasopharyngeal swab and 21 healthy children of the same age. Blood count, including platelet count (PLT), mean platelet volume (MPV) and other platelet indices, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and vitamin D (vit D) levels were compared. The influenza group showed lower PLT and platelet mass (PLT*MPV), and the non-influenza group showed significantly lower MPV, which was correlated with the vit D levels, but not CRP or ESR, and the value vit D*MPV was significantly lower in this group. These results revealed that platelet activation in viral respiratory tract infections in children, as measured by MPV, is related to the vit D level, with differences between influenza and non-influenza infection.ConclusionsViral respiratory tract infection in children can diminish the platelet size most likely by suppressing the platelet activation. This response is associated with low levels of vit D. Whether the vit D status is associated with the virus-platelet immune/inflammatory process needs further investigation.

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Section: Discussionmentioning

confidence: 56%

Relationship Between Vitamin D Level and Platelet Parameters in Children With Viral Respiratory Infections

et al. 2022

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“…In one study with 78 participants, there was a significant negative relationship between vitamin D level and MPV in CAD patients (20). In another study, there was a negative relationship between vitamin D levels and MPV levels in gestational diabetes mellitus (21). Cumhur et al (22) reported that there was no significant relationship between vitamin D deficiency and MPV levels on 434 healthy participants.…”

Section: Discussionmentioning

confidence: 94%

Relationship between vitamin D levels and platelet count: A retrospective study

Alanlı¹,

Küçükay²,

Yalcin³

2020

GMJ

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Aims: Vitamin D deficiency, increase in mean platelet volume (MPV) and high platelet counts are related to several diseases. The aim of this study is to analyze the relationship between vitamin D status and platelet count, MPV, age, gender, alkaline phosphatase (ALP), and uric acid on patients.Methods: This study included 899 patients, who did not have any chronic diseases and conditions that affected platelet counts. Calcium, magnesium, ALP, uric acid, 25-hydroxyvitamin D3 levels and 22 parameter hemogram; including MPV and platelet counts were analyzed. Participants were separated into three groups according to their 25-hydroxyvitamin D3 levels: serious deficiency (24.96 nmol/L), deficiency (24.96-49.92 nmol/L), and insufficiency (49.92-74.88 nmol/L). The difference among the groups were analyzed by using the one-way ANOVA test. The Pearson's correlation analysis was used to evaluate associations between 25-hydroxyvitamin D3 levels and other variables.Results: There was a significant negative correlation between 25-hydroxyvitamin D3 levels and platelet counts in groups (p=0.001, r=-0.108). The mean vitamin D level was 38.19±17.47 nmol/L in female participants and 42.68±12.48 nmol/L in males (p<0.001). A significant difference between platelet counts in serious vitamin D deficiency (286±68x10 9 /L) and insufficiency groups (268±64x10 9 /L) was also noted (p=0.008). Conclusions:There was a negative correlation between 25-hydroxyvitamin D3 levels and platelet counts in all groups. Low levels of 25-hydroxyvitamin D3 were associated with an increased platelet count in participants.

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“…Além disso, houve regulação dos feedbacks do sistema renina-angiotensina-aldosterona (SRAA) após suplementação com vitamina D (LUCISANO et al, 2013). Em gestantes, a Vitamina D também está relacionada a graves patologias como aborto espontâneo por aumento de citocina pró-inflamatórias no útero (WINZENBERG, 2016;GUR. et al, 2015).…”

Section: Resultsunclassified

Vitamina D na regulação do organismo humano e implicações de sua deficiência corporal

Rodrigues

Corrêa

Neto

et al. 2019

BJHR

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Relationship between mean platelet volume and vitamin D deficiency in gestational diabetes mellitus

Cited by 14 publications

References 33 publications

Relationship Between Vitamin D Level and Platelet Parameters in Children With Viral Respiratory Infections

Relationship Between Vitamin D Level and Platelet Parameters in Children With Viral Respiratory Infections

Relationship between vitamin D levels and platelet count: A retrospective study

Vitamina D na regulação do organismo humano e implicações de sua deficiência corporal

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