Melatonin prevents hyperglycemia in a model of sleep apnea

Kaminski, Renata Schenkel Rivera; Martinez, Dênis; Fagundes, Micheli; Martins, Emerson Ferreira; Montanari, Carolina Caruccio; Rosa, Darlan Pase da; Fiori, Cíntia Zappe; Marroni, Norma Possa

doi:10.1590/2359-3997000000012

Cited by 10 publications

(3 citation statements)

References 27 publications

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“…The involvement of the circadian biology with OSA and sleep disordered breathing also shows great promise ( 183 ). OSA individuals exhibit a circadian dysregulation of cortisol ( 184 ), and treatment with melatonin has been found to mitigate IH-induced hyperglycemia ( 185 ), insulin resistance, and microvascular damage ( 186 ). Research in these fields are on-going and may revel exciting new information about OSA etiology.…”

Section: Discussionmentioning

confidence: 99%

The Bidirectional Relationship Between Obstructive Sleep Apnea and Metabolic Disease

Framnes

Arble

2018

Front. Endocrinol.

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Obstructive sleep apnea (OSA) is a common sleep disorder, effecting 17% of the total population and 40–70% of the obese population (1, 2). Multiple studies have identified OSA as a critical risk factor for the development of obesity, diabetes, and cardiovascular diseases (3–5). Moreover, emerging evidence indicates that metabolic disorders can exacerbate OSA, creating a bidirectional relationship between OSA and metabolic physiology. In this review, we explore the relationship between glycemic control, insulin, and leptin as both contributing factors and products of OSA. We conclude that while insulin and leptin action may contribute to the development of OSA, further research is required to determine the mechanistic actions and relative contributions independent of body weight. In addition to increasing our understanding of the etiology, further research into the physiological mechanisms underlying OSA can lead to the development of improved treatment options for individuals with OSA.

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Section: Discussionmentioning

confidence: 99%

The Bidirectional Relationship Between Obstructive Sleep Apnea and Metabolic Disease

Framnes

Arble

2018

Front. Endocrinol.

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“…Melatonin prevents the wellrecognized increase in glucose levels that usually follows exposure to intermittent hypoxia in animal models of sleep apnea [26]. By modulating autophagy through the 5′ adenosine monophosphate-activated protein kinase pathway, melatonin protects against chronic intermittent hypoxia-induced cardiac hypertrophy in rats [27].…”

Section: Effect Of Melatonin On Reducing the Complications Caused By mentioning

confidence: 99%

A review of sleep disorders and melatonin

Xie

Chen

et al. 2017

Neurological Research

279

181

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Sleep disorders are a group of conditions that affect the ability to sleep well on a regular basis and cause significant impairments in social and occupational functions. Although currently approved medications are efficacious, they are far from satisfactory. Benzodiazepines, antidepressants, antihistamines and anxiolytics have the potential for dependence and addiction. Moreover, some of these medications can gradually impair cognition. Melatonin (N-acetyl-5-methoxytryptamine) is an endogenous hormone produced by the pineal gland and released exclusively at night. Exogenous melatonin supplementation is well tolerated and has no obvious short-or long-term adverse effects. Melatonin has been shown to synchronize the circadian rhythms, and improve the onset, duration and quality of sleep. It is centrally involved in anti-oxidation, circadian rhythmicity maintenance, sleep regulation and neuronal survival. This narrative review aims to provide a comprehensive overview of various therapeutic functions of melatonin in insomnia, sleep-related breathing disorders, hypersomnolence, circadian rhythm sleep-wake disorders and parasomnias. Melatonin offers an alternative treatment to the currently available pharmaceutical therapies for sleep disorders with significantly less side effects.

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“…Furthermore, melatonin ameliorates the complications caused by sleep-breathing disorders. The hypoxia-induced hyperglycemia in experimental studies for sleep apnea included 36 mice injected with IP melatonin for 21 days (135). It inhibits the expression of inflammatory cytokines (Tumor necrosis factor-alpha, Interleukin-6, and Cyclooxygenase-2) and fibrotic markers (PC1 and TGF-beta) (136).…”

Section: Melatonin and Light Therapymentioning

confidence: 99%

Beyond cognition and sleep: Stop the domino effect

AMIN¹,

KHASHABA²,

ALAZZAM³

et al. 2023

J Exp Clin Med

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Sleep problems, particularly sleep deprivation and fragmentations, are common hazards in modern lifestyles and maybe an unavoidable occupational drawback. Different metabolic or hereditary causes may induce sleep problems. Cognitive functions and the closely related metacognition, which depends significantly on decision making, are essential for learning and problem-solving. When impaired for any reason, the quality of life deteriorates, and the person may become dependent on others in severe cases of dysfunction. Sleep and cognition/metacognition are related, and an insult to one function may lead to the other domain's collapse. The present review highlights the significant causes and conditions of sleep problems, cognitive and metacognitive dysfunctions, the possible mechanisms, interactions, and the potential tools or agents that may improve them.

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Melatonin prevents hyperglycemia in a model of sleep apnea

Cited by 10 publications

References 27 publications

The Bidirectional Relationship Between Obstructive Sleep Apnea and Metabolic Disease

The Bidirectional Relationship Between Obstructive Sleep Apnea and Metabolic Disease

A review of sleep disorders and melatonin

Beyond cognition and sleep: Stop the domino effect

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