Tropical savannas are one of the most affected biomes worldwide by anthropogenic activities. The Cerrado biome, also referred to as the Brazilian Tropical Savanna, is one of the world's environmental hotspots due to its high biodiversity and endemism. Also, it is essential for water resources in South America and hydropower generation in Brazil. In this context, this study aimed to evaluate possible changes in water availability in the Cerrado due to the impacts of climate change throughout the 21st century under different emissions scenarios. The Soil and Water Assessment Tool (SWAT) was calibrated and validated in a watershed encompassing 51 237 km 2 . The regional climate models (RCMs) Eta-HadGEM-ES and Eta-MIROC5 under the representative concentration pathways (RCPs) 4.5 and 8.5 were used to simulate the streamflow changes in three time slices