Efeito da levodopa na mecânica coclear e no sistema auditivo eferente de indivíduos com doença de Parkinson

Lopes, Márcia da Silva; Melo, Aílton; Corona, Ana Paula; Nóbrega, Ana Caline

doi:10.1590/2317-1782/20182018249

Cited by 4 publications

(5 citation statements)

References 19 publications

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“…OAE response amplitudes were higher when the same patients with PD were tested without their medication (17). This result corroborates with the study of Lopes et al (19), who found higher DPOAE response amplitudes in patients with PD receiving low daily doses of dopaminergic medication compared to patients receiving higher doses.…”

Section: Otoacoustic Emissionssupporting

confidence: 90%

“…Indeed, a high-frequency age-related hearing impairment has been shown in studies that used pure-tone audiometry to evaluate the hearing sensitivity of patients with PD and age-matched control participants (HCs). On the one hand, multiple studies have demonstrated the same sloping audiometric pattern in patients with PD compared to HCs, consistent with the presence of an age-related hearing loss (17)(18)(19)(20). These studies did not find significant differences between patients with PD and HCs regarding pure-tone hearing thresholds.…”

Section: Audiological Measurements Peripheral Auditory Testsmentioning

confidence: 53%

“…In any case, this result indicates decreased to absent ES of TEOAEs in patients with PD, which may support the involvement of the efferent auditory pathway in the pathology of PD. Regarding ES of DPOAEs, both patients and HCs generally demonstrated adequate reduction during CAS and no significant difference could be demonstrated regarding the amount of ES between patients with PD and HCs (19). Nevertheless, a modulatory effect of dopaminergic medication dosage has been found on ES in patients with PD.…”

Section: Otoacoustic Emissionsmentioning

confidence: 77%

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Future Perspectives on the Relevance of Auditory Markers in Prodromal Parkinson's Disease

et al. 2020

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Research on auditory processing in Parkinson's disease (PD) has recently made substantial progress. At present, evidence has been found for altered auditory processing in the clinical stage of PD. The auditory alterations in PD have been demonstrated with low-cost and non-invasive assessments that are already used in routine clinical practice. Since auditory alterations have been reported early in disease progression, it would be highly relevant to investigate whether auditory markers could be provided in the prodromal stage of PD. In addition, auditory alterations in early stage PD might be modulated by dopaminergic medication. Therefore, the aim of this review is (1) to summarize the literature on auditory processing in PD with a specific focus on the early disease stages, (2) to give future perspectives on which audiological and electrophysiological measurements could be useful in the prodromal stage of PD and (3) to assess the effect of dopaminergic medication on potential auditory markers in the prodromal stage of PD.

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Section: Otoacoustic Emissionssupporting

confidence: 90%

Section: Audiological Measurements Peripheral Auditory Testsmentioning

confidence: 53%

Section: Otoacoustic Emissionsmentioning

confidence: 77%

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Future Perspectives on the Relevance of Auditory Markers in Prodromal Parkinson's Disease

et al. 2020

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“…Furthermore, when controlling for baseline differences regarding TEOAE signal amplitudes in the condition without CAS, the normalized index of ES did not differ significantly between patients with PD and HCs. Consistent with Lopes et al (2019), these findings suggest normal MOC function in patients with PD. However, if CAS fails to reduce the TEOAE signal amplitude by 1 dB or more, ES is generally described as abnormal (Murdin & Davies, 2008).…”

Section: Discussionsupporting

confidence: 70%

“…In patients with PD evaluated with dopaminergic medication, increased TEOAE signal amplitudes during contralateral acoustic stimulation (CAS) have been observed, suggesting reduced ES and a dysfunction of the MOC system (Di Mauro et al, 2017). In contrast, Lopes et al (2019) found generally normal ES of DPOAEs in patients with PD compared to HCs. However, when patients with PD were stratified by daily levodopa equivalent dose (LED), patients receiving higher doses demonstrated greater ES compared to patients with PD receiving lower doses.…”

mentioning

confidence: 99%

The Effect of Parkinson's Disease on Otoacoustic Emissions and Efferent Suppression of Transient Evoked Otoacoustic Emissions

Groote

Bockstael

Botteldooren

et al. 2021

J Speech Lang Hear Res

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Purpose Several studies have demonstrated increased auditory thresholds in patients with Parkinson's disease (PD) based on subjective tonal audiometry. However, the pathophysiological mechanisms underlying auditory dysfunction in PD remain elusive. The primary aim of this study was to investigate cochlear and olivocochlear function in PD using objective measurements and to assess the effect of dopaminergic medication on auditory function. Method Eighteen patients with PD and 18 gender- and age-matched healthy controls (HCs) were included. Patients with PD participated in medication on and off conditions. Linear mixed models were used to determine the effect of PD on tonal audiometry, transient evoked and distortion product otoacoustic emissions (OAEs), and efferent suppression (ES). Results Tonal audiometry revealed normal auditory thresholds in patients with PD for their age across all frequencies. OAE signal amplitudes demonstrated a significant interaction effect between group (PD vs. HC) and frequency, indicating decreased OAEs at low frequencies and increased OAEs at high frequencies in patients with PD. No significant differences were found between patients with PD and HCs regarding ES. In addition, no significant effect of medication status was found on auditory measurements in patients with PD. Conclusions Altered OAEs support the hypothesis of cochlear alterations in PD. No evidence was found for the involvement of the medial olivocochlear system. Altogether, OAEs may provide an objective early indicator of auditory alterations in PD and should complement subjective tonal audiometry when assessing and monitoring auditory function in PD.

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Evaluation of Efferent Auditory System and Hearing Quality in Parkinson's Disease: Is the Difficulty in Speech Understanding in Complex Listening Conditions Related to Neural Degeneration or Aging?

Gökay

Gündüz

Söke

et al. 2021

J Speech Lang Hear Res

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Purpose The effects of neurological diseases on the auditory system have been a notable issue for investigators because the auditory pathway is closely associated with neural systems. The purposes of this study are to evaluate the efferent auditory system function and hearing quality in Parkinson's disease (PD) and to compare the findings with age-matched individuals without PD to present a perspective on aging. Method The study included 35 individuals with PD (mean age of 48.50 ± 8.00 years) and 35 normal-hearing peers (mean age of 49 ± 10 years). The following tests were administered for all participants: the first section of the Speech, Spatial and Qualities of Hearing Scale; pure-tone audiometry, speech audiometry, tympanometry, and acoustic reflexes; and distortion product otoacoustic emissions (DPOAEs) and contralateral suppression of DPOAEs. SPSS Version 25 was used for statistical analyses, and values of p < .05 were considered statistically significant. Results There were no statistically significant differences in the pure-tone audiometry thresholds and DPOAE responses between the individuals with PD and their normal-hearing peers ( p = .732). However, statistically significant differences were found between the groups in suppression levels of DPOAEs and hearing quality ( p < .05). In addition, a statistically significant and positive correlation was found between the amount of suppression at some frequencies and the Speech, Spatial and Qualities of Hearing Scale scores. Conclusions This study indicates that medial olivocochlear efferent system function and the hearing quality of individuals with PD were affected adversely due to the results of PD pathophysiology on the hearing system. For optimal intervention and follow-up, tasks related to hearing quality in daily life can also be added to therapies for PD.

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Efeito da levodopa na mecânica coclear e no sistema auditivo eferente de indivíduos com doença de Parkinson

Cited by 4 publications

References 19 publications

Future Perspectives on the Relevance of Auditory Markers in Prodromal Parkinson's Disease

Future Perspectives on the Relevance of Auditory Markers in Prodromal Parkinson's Disease

The Effect of Parkinson's Disease on Otoacoustic Emissions and Efferent Suppression of Transient Evoked Otoacoustic Emissions

Evaluation of Efferent Auditory System and Hearing Quality in Parkinson's Disease: Is the Difficulty in Speech Understanding in Complex Listening Conditions Related to Neural Degeneration or Aging?

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