Frontal lobe alterations in schizophrenia: a review

Mubarik, Ateeq; Tohid, Hassaan

doi:10.1590/2237-6089-2015-0088

Cited by 60 publications

(32 citation statements)

References 93 publications

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“…An interaction effect, accounting for age and sex, was not signi cant between group and FAA (f = 1.30, p = 0.253, η p 2 = 0.100). However, for between-subjects effects (schizophrenia vs. healthy control), we observed a signi cant difference in F4-F3 with the eyes-open condition (f [2,49] = 3.70, p = 0.032, η p 2 = 0.131). Alpha asymmetry in the schizophrenia group was lower than that in the healthy controls (-0.10 ± 0.04 vs. -0.05 ± 0.05, corrected p = 0.027, 95% CI = 0.01 to 0.10) ( Fig.…”

Section: Resultsmentioning

confidence: 63%

“…There were no signi cant differences in F4-F3 with eyes open between patients with MDD and healthy controls (corrected p = 0.630, 95% CI = -0.02 to 0.07), or between MDD and schizophrenia patients (corrected p = 0.434, 95% CI = -0.02 to 0.08). There were no signi cant differences found in F4-F3 with eyes-closed (f [2,49] = 0.64, p = 0.532, η p 2 = 0.025), or in F8-F7 with eyes-open or -closed (f [2,49] = 0.96, p = 0.391, η p 2 = 0.038; f [2,49] = 0.11, p = 0.896, η p 2 = 0.004). In correlation analysis, there were no associations between alpha asymmetry and clinical symptoms (depression and F4-…”

Section: Resultsmentioning

confidence: 90%

“…Alpha asymmetry in the mid-frontal area is commonly observed in patients with psychiatric disorders [21,30]. In addition, metabolic and structural alterations in the mid-frontal region are thought to be dominant in patients with schizophrenia [49]. Future studies should determine the association between cognitive de cits and alpha asymmetry in schizophrenia patients.…”

Section: Discussionmentioning

confidence: 98%

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Comparison of Frontal Alpha Asymmetry Among Schizophrenia Patients, Major Depressive Disorder, and Healthy Controls

Jang¹,

Lee

et al. 2020

Preprint

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Background Electroencephalography (EEG) frontal alpha asymmetry (FAA) has been observed in several psychiatric disorders. However, dominance in left or right frontal alpha activity remains inconsistent in patients with major depressive disorder (MDD), patients with schizophrenia, and healthy controls. This study compared FAA among patients with MDD, schizophrenia, and healthy control. Methods We recruited 20 patients with MDD, 18 patients with schizophrenia, and 16 healthy individuals. The EEG alpha frequency ranged from 8.0 to 12.0 Hz. FAA was expressed as the difference between absolute power values in both the right and left electrodes in the alpha frequency range (common-log-transformed F4–F3 and F8–F7). Hamilton depression and anxiety rating scales were evaluated in patients with MDD. Positive and negative syndrome scales were evaluated in patients with schizophrenia. Results Patients with schizophrenia showed significantly lower left frontal lobe activity than healthy controls (FAA, schizophrenia vs. healthy: -0.10 ± 0.05 vs. -0.05 ± 0.05). There were no significant differences in FAA between patients with schizophrenia and MDD as well as between patients with MDD and healthy controls. Conclusions The present study suggests that frontal alpha asymmetry indicates a breaking neural activity in schizophrenia. Breaking rhythmic activity as a left-lateralized FAA can be a neuropathological attribute in patients with schizophrenia but lack of sample size and information such as medication and duration of illness, all of which could make it difficult generalize finding.

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Section: Resultsmentioning

confidence: 63%

Section: Resultsmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 98%

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Comparison of Frontal Alpha Asymmetry Among Schizophrenia Patients, Major Depressive Disorder, and Healthy Controls

Jang¹,

Lee

et al. 2020

Preprint

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“…Recent studies have shown dysfunction of the precentral gyrus (PreCG) has long been thought to play a role in the impairments of voluntary movement associated with Schizophrenia and it has significantly reduced functional activity (FC) in patients with schizophrenia [3,4] . Also, schizophrenia is associated with volume deficits in PreCG [5] .…”

Section: Introductionmentioning

confidence: 99%

Precentral gyrus abnormal connectivity in male and female patients with schizophrenia

Zarei¹

2018

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Aim: Dysfunction of the precentral gyrus plays a role in the impairments of voluntary movement associated with schizophrenia and it has significantly reduced functional activity in patients with schizophrenia. The aim of this study was to demonstrate the precentral gyrus alteration and its abnormal connectivity in schizophrenia. Methods:The region of interest-based analysis method was used to investigate the precentral gyrus connectivity alteration in schizophrenia. The resting-state functional magnetic resonance imaging data of healthy control subjects and patients with schizophrenia (Centers of Biomedical Research Excellence data set) was used to examine the aberrant functional brain connectome in schizophrenia. This data set contains raw anatomical and functional magnetic resonance data from 72 patients with schizophrenia and 75 healthy controls, ranging in age from 18 to 65 years old. Results:Our results show precentral gyrus has abnormal communication with thalamus, hippocampus, parahippocampal gyrus, posterior division of supramarginal gyrus and medial prefrontal cortex (pFDR = 0.05). This information is expected to provide a better understanding of altered functional connectivity of the precentral gyrus in the male and female patients with schizophrenia. Conclusion:Collectively, these findings support the hypothesis that precentral gyrus has an abnormal connectivity in schizophrenia and this alteration is not the same in the male and female patients with schizophrenia.

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“…Recent studies shows that Precentral gyrus (PreCG) has significant reduced of functional activity (FC) in Schizophrenia (SCH) patients [16,13]. Also, SCH is associated with volume deficits in Precentral gyrus [15].…”

Section: Introductionmentioning

confidence: 99%

Precentral gyrus abnormal connectivity in male and female schizophrenia patients

Zarei

2017

Preprint

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The present study demonstrates the Precentral gyrus (PreCG) alteration and its abnormal connectivities in Schizophrenia (SCH) patients. The resting-sate functional magnetic resonance imaging (rs-fMRI) data of healthy control subjects and SCH patients (Centre for Biomedical Research Excellence data set) are used to examine the aberrant functional brain connectome in SCH which contains raw anatomical and functional MR data from 72 patients with Schizophrenia and 75 healthy controls, ranging in age from 18 to 65 years old. Our results show that PreCG has abnormal communication with Thalamus, Hippocampus, Parahippocampal Gyrus (pPaHC), posterior division of Supramarginal Gyrus (pSMG) and medial prefrontal cortex (mPFC) (p-FDR=0.05).

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Frontal lobe alterations in schizophrenia: a review

Cited by 60 publications

References 93 publications

Comparison of Frontal Alpha Asymmetry Among Schizophrenia Patients, Major Depressive Disorder, and Healthy Controls

Comparison of Frontal Alpha Asymmetry Among Schizophrenia Patients, Major Depressive Disorder, and Healthy Controls

Precentral gyrus abnormal connectivity in male and female patients with schizophrenia

Precentral gyrus abnormal connectivity in male and female schizophrenia patients

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