Effects of augmentation agents in autistic disorder patients treated with risperidone: a systematic review and a meta-analysis

Soares, Amanda; Shiozawa, Pedro; Trevizol, Alisson Paulino; Paula, Cristiane Silvestre de; Lowenthal, Rosane; Cordeiro, Quirino

doi:10.1590/2237-6089-2015-0068

Cited by 1 publication

(1 citation statement)

References 10 publications

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“…Other neuroleptics whose potential was explored in ASD include olanzapine [NCT00057408, NCT00183404], lurasidone [NCT01911442, NCT01620060, NCT01914393, NCT01731119], brexipiprazole [NCT03292848], and ziprasidone [NCT00208559]. Effects of neuroleptics on ASD-associated irritability and hyperactivity are promising, and though some studies report improvement in the social sphere or in stereotypy [ 271 ], most fail to address core ASD symptoms [ 272 , 273 ]. Their influence on immune abnormalities is probably much more pronounced in in vitro than in vivo conditions, and although MCP-1 was found to be correlated with deficits in social sphere [ 150 ], improper communication [ 174 ], and impaired adaptive skills [ 138 , 174 ], none of the fields were influenced with risperidone treatment.…”

Section: Pivotal Role Of Immune System As a Potential Target For Novementioning

confidence: 99%

Immune Abnormalities in Autism Spectrum Disorder—Could They Hold Promise for Causative Treatment?

Gładysz¹,

Krzywdzińska²,

Hozyasz³

2018

Mol Neurobiol

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Autism spectrum disorders (ASD) are characterized by impairments in language and communication development, social behavior, and the occurrence of stereotypic patterns of behavior and interests. Despite substantial speculation about causes of ASD, its exact etiology remains unknown. Recent studies highlight a link between immune dysfunction and behavioral traits. Various immune anomalies, including humoral and cellular immunity along with abnormalities at the molecular level, have been reported. There is evidence of altered immune function both in cerebrospinal fluid and peripheral blood. Several studies hypothesize a role for neuroinflammation in ASD and are supported by brain tissue and cerebrospinal fluid analysis, as well as evidence of microglial activation. It has been shown that immune abnormalities occur in a substantial number of individuals with ASD. Identifying subgroups with immune system dysregulation and linking specific cellular immunophenotypes to different symptoms would be key to defining a group of patients with immune abnormalities as a major etiology underlying behavioral symptoms. These determinations would provide the opportunity to investigate causative treatments for a defined patient group that may specifically benefit from such an approach. This review summarizes recent insights into immune system dysfunction in individuals with ASD and discusses the potential implications for future therapies.Electronic supplementary materialThe online version of this article (10.1007/s12035-017-0822-x) contains supplementary material, which is available to authorized users.

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Section: Pivotal Role Of Immune System As a Potential Target For Novementioning

confidence: 99%

Immune Abnormalities in Autism Spectrum Disorder—Could They Hold Promise for Causative Treatment?

Gładysz¹,

Krzywdzińska²,

Hozyasz³

2018

Mol Neurobiol

View full text Add to dashboard Cite

show abstract

Effects of augmentation agents in autistic disorder patients treated with risperidone: a systematic review and a meta-analysis

Cited by 1 publication

References 10 publications

Immune Abnormalities in Autism Spectrum Disorder—Could They Hold Promise for Causative Treatment?

Immune Abnormalities in Autism Spectrum Disorder—Could They Hold Promise for Causative Treatment?

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