2016
DOI: 10.1590/2237-6089-2015-0066
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Heat stroke during long-term clozapine treatment: should we be concerned about hot weather?

Abstract: This report aims to alert clinicians take this condition into consideration among other differential diagnoses, especially nowadays with the rise in global temperatures, and to highlight the need for accurate diagnosis of clinical events during pharmacological intervention, in order to improve treatment decisions and outcomes.

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Cited by 11 publications
(12 citation statements)
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“…We identified a body of research related to populations and contexts that are anticipated to be more vulnerable to climate change and its mental health impacts. People taking certain psychotropic medications (including hypnotics, anxiolytics, and antipsychotics) are at increased risk of heatstroke and death as a result of high temperatures, possibly due to disruptions in thermoregulation triggered by some psychotropic medications [ 56 , 66 ]. One study from Australia showed that people living with obsessive-compulsive disorder (OCD) experience obsessions and compulsions directly aligned with climate change concerns [ 67 ].…”
Section: Resultsmentioning
confidence: 99%
“…We identified a body of research related to populations and contexts that are anticipated to be more vulnerable to climate change and its mental health impacts. People taking certain psychotropic medications (including hypnotics, anxiolytics, and antipsychotics) are at increased risk of heatstroke and death as a result of high temperatures, possibly due to disruptions in thermoregulation triggered by some psychotropic medications [ 56 , 66 ]. One study from Australia showed that people living with obsessive-compulsive disorder (OCD) experience obsessions and compulsions directly aligned with climate change concerns [ 67 ].…”
Section: Resultsmentioning
confidence: 99%
“…Of the 31 included studies, the majority reported on heat events (39%, eight papers [ 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 ]; four case studies [ 37 , 38 , 39 , 40 ]), followed by floods (26%, seven papers [ 41 , 42 , 43 , 44 , 45 , 46 , 47 ]; one thesis [ 48 ]), wildfires (23%, seven papers [ 49 , 50 , 51 , 52 , 53 , 54 , 55 ]), wildfire and flooding (3%, one paper [ 56 ]), hurricanes (6%, one paper [ 57 ]; one thesis [ 58 ]), and droughts (3%, one paper [ 59 ]). The studies were conducted in nine different countries/regions: the USA (35%, n = 11) [ 30 , 32 , 41 , 42 , 45 , 46 , 47 , 48 , 57 , 58 , 59 ]; Canada (26%, n = 8) [ 38 , 44 , 50 , 51 , 52 , 53 , 54 , 55 ]; Italy (10%, n = 3) [ …”
Section: Resultsmentioning
confidence: 99%
“…The studies were conducted in nine different countries/regions: the USA (35%, n = 11) [ 30 , 32 , 41 , 42 , 45 , 46 , 47 , 48 , 57 , 58 , 59 ]; Canada (26%, n = 8) [ 38 , 44 , 50 , 51 , 52 , 53 , 54 , 55 ]; Italy (10%, n = 3) [ 29 , 34 , 35 ]; Australia (6%, n = 2) [ 49 , 56 ]; Brazil (6%, n = 2) [ 36 , 37 ]; England (6%, n = 2) [ 33 , 43 ]; Hong Kong (3%, n = 1) [ 39 ]; South Korea (3%, n = 1) [ 31 ]; and Taiwan (3%, n = 1) [ 40 ] (rounding errors account for 2%). Twenty-six studies (84%) were quantitative [ 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 41 , 42 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 ...…”
Section: Resultsmentioning
confidence: 99%
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“…Higher risks have been identified in patients with developmental disorders and schizophrenia. Furthermore, heatwaves and extremely high temperatures have been associated with increased mortality in people suffering from mental illness [ 3 , 18 , 19 , 20 , 21 , 22 ]. Hence, research has shown that strong meteorological stimuli appear to exacerbate symptoms in people with mental disorder.…”
Section: Introductionmentioning
confidence: 99%