Integrity of cognitive functions in trigeminal nerve stimulation trials in neuropsychiatry

Trevizol, Alisson Paulino; Bonadia, Bianca; Gomes, July Silveira; Cordeiro, Quirino; Shiozawa, Pedro

doi:10.1590/2237-6089-2015-0048

Cited by 6 publications

(3 citation statements)

References 5 publications

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“…The TNS was reported to be a well-tolerated technique, with no severe adverse effect reported, and to have impressive results for MDD. Previous studies on the impact of TNS on cognition reported no changes at cognitive evaluations pre and post stimulation (22) and unlike what can be observed with continuous current techniques such as transcranial direct current stimulation, no skin lesions were reported (23). This promising, safe and easy-to-use new neuromodulation technique could be a useful tool for psychiatric disorders treatment, given the positive results reported so far on a variety of disorders.…”

Section: Literature Reviewmentioning

confidence: 62%

Trigeminal Nerve Stimulation for Major Depressive Disorder: An Updated Systematic Review

Trevizol

Cordeiro

2016

Arch Neurosci

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Context: Trigeminal nerve stimulation (TNS) is a promising non-invasive brain stimulation intervention. The TNS has been proposed for major depressive disorder (MDD) with auspicious results. The aim of this study was to review the literature on TNS for MDD. Evidence Acquisition: Systematic review, using MEDLINE and EMBASE, of first articles available until 22nd of April 2016. Results: We included seven studies; six of them were open-label studies and one sham-controlled randomized double-blinded trial. Most studies had small sample sizes. Two studies were on MDD with comorbid posttraumatic stress disorder and one study focused on the elderly population. Two different protocols of stimulation were reported. Studies had interesting positive results for treating MDD. Conclusions:The TNS was reported to be well tolerated, with no severe adverse effect reported, and had impressive results for MDD. This promising, safe and easy-to-use new neuromodulation technique could be a useful tool for MDD treatment. However, the results reported in the studies performed so far must be analyzed under the strict limitations of the study design. Most of the studies on TNS are case studies or open-label trials with very small sample sizes. We acknowledge that it is the time to initiate more rigorous sham-controlled trials to better understand the huge potential involved with this technique, which could lead to the development of more accessible, easy-to-use, safe and non-invasive technology.

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Section: Literature Reviewmentioning

confidence: 62%

Trigeminal Nerve Stimulation for Major Depressive Disorder: An Updated Systematic Review

Trevizol

Cordeiro

2016

Arch Neurosci

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“…In particular, these include VNS-induced autonomic side effects due to the presence in the vagus nerve of visceral efferent components affecting cardiac and laryngeal function [ 19 , 20 ], and the exposure to surgery-related risks such as peritracheal hematoma and infections [ 21 , 22 ]. Since then, TNS has been tested in the treatment of different neurological and psychiatric conditions, proving beneficial for seizure control, depression, migraine, attention deficit hyperactivity disorder (ADHD), post-traumatic stress disorder, and tinnitus [ 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 ]. TNS has now reached a considerable diffusion in clinical practice, allowing for the development of a substantial base of knowledge supporting its possible therapeutic applications.…”

Section: Trigeminal Nerve Stimulation: Use and Safetymentioning

confidence: 99%

Cognitive Functions following Trigeminal Neuromodulation

Mercante,

Enrico,

Deriu

2023

Biomedicines

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Vast scientific effort in recent years have been focused on the search for effective and safe treatments for cognitive decline. In this regard, non-invasive neuromodulation has gained increasing attention for its reported effectiveness in promoting the recovery of multiple cognitive domains after central nervous system damage. In this short review, we discuss the available evidence supporting a possible cognitive effect of trigeminal nerve stimulation (TNS). In particular, we ask that, while TNS has been widely and successfully used in the treatment of various neuropsychiatric conditions, as far as research in the cognitive field is concerned, where does TNS stand? The trigeminal nerve is the largest cranial nerve, conveying the sensory information from the face to the trigeminal sensory nuclei, and from there to the thalamus and up to the somatosensory cortex. On these bases, a bottom-up mechanism has been proposed, positing that TNS-induced modulation of the brainstem noradrenergic system may affect the function of the brain networks involved in cognition. Nevertheless, despite the promising theories, to date, the use of TNS for cognitive empowering and/or cognitive decline treatment has several challenges ahead of it, mainly due to little uniformity of the stimulation protocols. However, as the field continues to grow, standardization of practice will allow for data comparisons across studies, leading to optimized protocols targeting specific brain circuitries, which may, in turn, influence cognition in a designed manner.

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“…Electric stimulation was performed at 120 Hz with pulse wave duration of 250 µs, continuously, for 30 minutes per day. Square auto-adhesive rubber electrodes of 25 cm 2 were placed over supraorbital trigeminal branches (V1) bilaterally according to our previous protocol (Trevizol et al, 2016a). To assess OCD and MDD symptoms, we used the Yale-Brown Obsessive-Compulsive Scale and the 17item Hamilton Depression Rating Scale.…”

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confidence: 99%

Trigeminal nerve stimulation for the treatment of major depressive disorder and obsessive-compulsive disorder: a case study

Trevizol¹,

Sato²,

Cordeiro³

2017

Asia Pac J Clin Trials Nerv Syst Dis

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Excessive activities in orbitofrontal-striatal regions, medial and lateral frontal areas, such as the supplementary motor area, anterior cingulate, dorsolateral prefrontal cortex and parietal regions (Trevizol et al., 2016b) in the brain are associated with the inability of obsessive-compulsive disorder (OCD) patients to suppress intrusive thoughts, impulses, or images and repetitive motor responses. Neuromodulation techniques have been proposed as add-on strategies for modulating brain areas involved in OCD symptoms (Trevizol et al., 2016e). Trigeminal nerve stimulation (TNS) is a novel neuromodulation technique based on the hypothesis that through the stimulation of a cranial nerve, activities in cortical and subcortical cerebral areas could be modulated. To date, effects of TNS on OCD have not yet been reported.

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Integrity of cognitive functions in trigeminal nerve stimulation trials in neuropsychiatry

Cited by 6 publications

References 5 publications

Trigeminal Nerve Stimulation for Major Depressive Disorder: An Updated Systematic Review

Trigeminal Nerve Stimulation for Major Depressive Disorder: An Updated Systematic Review

Cognitive Functions following Trigeminal Neuromodulation

Trigeminal nerve stimulation for the treatment of major depressive disorder and obsessive-compulsive disorder: a case study

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