Where does her mood come from? An organic approach to a once functional patient

Abstract

Schizophrenia is a chronic disease that affects about 1% of the population worldwide. The main symptoms of the disorder are altered affection, delusions, and hallucinations. Graves' disease is an autoimmune condition in which antibodies increase the production and release of thyroid hormones. There are reports about the development of mood symptoms in patients with Graves' disease that remit with adequate treatment.

Association of Thyrotoxicosis With Mania

“…The literature notes that thyroid diseases can trigger psychiatric illness (anxiety, depression, mania and psychosis) (7). Our case raises the question as to whether the patient's manic episode was a manifestation of her thyroid dysfunction.…”

“…Although there are no well-established guidelines for treatment of mania associated with thyrotoxicosis, some studies suggest that patients with this condition should first be treated by restoring them to euthyroid states (1,7). Additional treatment with beta-adrenergic antagonists is also helpful.…”

“…Some studies suggest that an episode of hyperthyroidism influences affective modulation in a time frame that exceeds the period of thyroid hormone excess (1). Cross-sectional studies suggest that there may be longterm effects on cognitive function and affective modulation following hyperthyroidism (7).…”